8BB1

T3 SAM lyase in complex with S-adenosylmethionine synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004478	molecular_function	methionine adenosyltransferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
A	0030955	molecular_function	potassium ion binding
A	0033353	biological_process	L-methionine cycle
A	0042802	molecular_function	identical protein binding
B	0000287	molecular_function	magnesium ion binding
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0030955	molecular_function	potassium ion binding
B	0033353	biological_process	L-methionine cycle
B	0042802	molecular_function	identical protein binding
C	0000287	molecular_function	magnesium ion binding
C	0004478	molecular_function	methionine adenosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0030955	molecular_function	potassium ion binding
C	0033353	biological_process	L-methionine cycle
C	0042802	molecular_function	identical protein binding
D	0000287	molecular_function	magnesium ion binding
D	0004478	molecular_function	methionine adenosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0030955	molecular_function	potassium ion binding
D	0033353	biological_process	L-methionine cycle
D	0042802	molecular_function	identical protein binding
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
G	0016740	molecular_function	transferase activity
G	0016829	molecular_function	lyase activity
G	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
H	0016740	molecular_function	transferase activity
H	0016829	molecular_function	lyase activity
H	0047625	molecular_function	S-adenosyl-L-methionine lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY

Chain	Residue	Details
A	GLY115-TYR125

---

site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
A	GLY258-ASP266

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7629147","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1MXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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