8B9N

Crystal structure of NEI domain of mouse NEIL3 trapped in covalent complex with ssDNA with abasic site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0008270	molecular_function	zinc ion binding
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0019104	molecular_function	DNA N-glycosylase activity
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0008270	molecular_function	zinc ion binding
C	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
C	0019104	molecular_function	DNA N-glycosylase activity

Functional Information from PROSITE/UniProt

site_id	PS01242
Number of Residues	27
Details	ZF_FPG_1 Zinc finger FPG-type signature. Cgq..CHskItvcrfgens..RMtyFCphCQ

Chain	Residue	Details
A	CYS255-GLN281

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	ZN_FING: FPG-type => ECO:0000255|PROSITE-ProRule:PRU00391

Chain	Residue	Details
A	LYS248-LYS282
C	LYS248-LYS282

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with DNA; via amino nitrogen => ECO:0000305|PubMed:20185759

Chain	Residue	Details
A	VAL2
C	VAL2

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASN193
A	ARG272
C	ASN193
C	ARG272

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for monofunctional glycosylase activity => ECO:0000250

Chain	Residue	Details
A	VAL2
C	VAL2

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Required for glycosylase activity => ECO:0000250

Chain	Residue	Details
A	LYS82
C	LYS82

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