8B7O

X-ray structure of Auranofin-human H-chain ferritin

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004322	molecular_function	ferroxidase activity
AAA	0005506	molecular_function	iron ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005576	cellular_component	extracellular region
AAA	0005634	cellular_component	nucleus
AAA	0005737	cellular_component	cytoplasm
AAA	0005764	cellular_component	lysosome
AAA	0005776	cellular_component	autophagosome
AAA	0005829	cellular_component	cytosol
AAA	0006826	biological_process	iron ion transport
AAA	0006879	biological_process	intracellular iron ion homeostasis
AAA	0006914	biological_process	autophagy
AAA	0006955	biological_process	immune response
AAA	0008198	molecular_function	ferrous iron binding
AAA	0008199	molecular_function	ferric iron binding
AAA	0008285	biological_process	negative regulation of cell population proliferation
AAA	0030218	biological_process	erythrocyte differentiation
AAA	0042802	molecular_function	identical protein binding
AAA	0044754	cellular_component	autolysosome
AAA	0048147	biological_process	negative regulation of fibroblast proliferation
AAA	0070062	cellular_component	extracellular exosome
AAA	0070288	cellular_component	ferritin complex
AAA	0110076	biological_process	negative regulation of ferroptosis
AAA	0140315	molecular_function	iron ion sequestering activity
AAA	1904724	cellular_component	tertiary granule lumen
AAA	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
AAA	ASP126-LYS146

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
AAA	GLU61-ARG79

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1992356","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FHA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Essential for association with cargo receptor NCOA4","evidences":[{"source":"PubMed","id":"26436293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details