Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8B6F

Cryo-EM structure of NADH:ubiquinone oxidoreductase (complex-I) from respiratory supercomplex of Tetrahymena thermophila

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A0	0005543	molecular_function	phospholipid binding
A0	0006629	biological_process	lipid metabolic process
A0	0008915	molecular_function	lipid-A-disaccharide synthase activity
A0	0009245	biological_process	lipid A biosynthetic process
A0	0016020	cellular_component	membrane
A0	0016740	molecular_function	transferase activity
A0	0016757	molecular_function	glycosyltransferase activity
A1	0005739	cellular_component	mitochondrion
A1	0044877	molecular_function	protein-containing complex binding
A2	0005737	cellular_component	cytoplasm
A2	0006457	biological_process	protein folding
A2	0044183	molecular_function	protein folding chaperone
A2	0051082	molecular_function	unfolded protein binding
A2	0051087	molecular_function	protein-folding chaperone binding
A3	0016874	molecular_function	ligase activity
AA	0003954	molecular_function	NADH dehydrogenase activity
AA	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AA	0015990	biological_process	electron transport coupled proton transport
AA	0016020	cellular_component	membrane
AA	0016491	molecular_function	oxidoreductase activity
AA	0042773	biological_process	ATP synthesis coupled electron transport
AB	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AB	0016020	cellular_component	membrane
AB	0016491	molecular_function	oxidoreductase activity
AB	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AB	0042773	biological_process	ATP synthesis coupled electron transport
AB	0046872	molecular_function	metal ion binding
AB	0051536	molecular_function	iron-sulfur cluster binding
AB	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AB	1902600	biological_process	proton transmembrane transport
AC	0005886	cellular_component	plasma membrane
AC	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AC	0016491	molecular_function	oxidoreductase activity
AC	0031966	cellular_component	mitochondrial membrane
AC	0042773	biological_process	ATP synthesis coupled electron transport
AC	1902600	biological_process	proton transmembrane transport
AD	0005739	cellular_component	mitochondrion
AD	0005743	cellular_component	mitochondrial inner membrane
AD	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AD	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AD	0010181	molecular_function	FMN binding
AD	0046872	molecular_function	metal ion binding
AD	0051287	molecular_function	NAD binding
AD	0051536	molecular_function	iron-sulfur cluster binding
AD	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AD	1902600	biological_process	proton transmembrane transport
AE	0005739	cellular_component	mitochondrion
AE	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AE	0016491	molecular_function	oxidoreductase activity
AE	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AE	0048038	molecular_function	quinone binding
AE	0051287	molecular_function	NAD binding
AH	0003954	molecular_function	NADH dehydrogenase activity
AH	0005743	cellular_component	mitochondrial inner membrane
AH	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AH	0009060	biological_process	aerobic respiration
AH	0016020	cellular_component	membrane
AH	0016491	molecular_function	oxidoreductase activity
AH	1902600	biological_process	proton transmembrane transport
AI	0003954	molecular_function	NADH dehydrogenase activity
AI	0005743	cellular_component	mitochondrial inner membrane
AI	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AI	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AI	0016491	molecular_function	oxidoreductase activity
AI	0046872	molecular_function	metal ion binding
AI	0051536	molecular_function	iron-sulfur cluster binding
AI	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AI	0098796	cellular_component	membrane protein complex
AI	1902494	cellular_component	catalytic complex
AI	1902600	biological_process	proton transmembrane transport
AL	0003954	molecular_function	NADH dehydrogenase activity
AL	0005739	cellular_component	mitochondrion
AL	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AL	0009060	biological_process	aerobic respiration
AL	0016020	cellular_component	membrane
AL	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AL	0046872	molecular_function	metal ion binding
AL	0051536	molecular_function	iron-sulfur cluster binding
AL	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0022904	biological_process	respiratory electron transport chain
AO	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AO	0016491	molecular_function	oxidoreductase activity
AO	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AO	1902600	biological_process	proton transmembrane transport
AP	0005743	cellular_component	mitochondrial inner membrane
AP	0006979	biological_process	response to oxidative stress
AP	0016020	cellular_component	membrane
AP	0045271	cellular_component	respiratory chain complex I
AR	0005743	cellular_component	mitochondrial inner membrane
AR	0022900	biological_process	electron transport chain
AS	0005743	cellular_component	mitochondrial inner membrane
AS	0006979	biological_process	response to oxidative stress
AT	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AT	0009060	biological_process	aerobic respiration
AT	0015990	biological_process	electron transport coupled proton transport
AT	0016491	molecular_function	oxidoreductase activity
AT	0045271	cellular_component	respiratory chain complex I
AT	0046872	molecular_function	metal ion binding
AT	0048038	molecular_function	quinone binding
AT	0051536	molecular_function	iron-sulfur cluster binding
AT	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AV	0000035	molecular_function	acyl binding
AV	0000036	molecular_function	acyl carrier activity
AV	0005739	cellular_component	mitochondrion
AV	0006629	biological_process	lipid metabolic process
AV	0006631	biological_process	fatty acid metabolic process
AV	0006633	biological_process	fatty acid biosynthetic process
AW	0000035	molecular_function	acyl binding
AW	0000036	molecular_function	acyl carrier activity
AW	0005739	cellular_component	mitochondrion
AW	0006629	biological_process	lipid metabolic process
AW	0006631	biological_process	fatty acid metabolic process
AW	0006633	biological_process	fatty acid biosynthetic process
AX	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AX	0016020	cellular_component	membrane
AX	0016491	molecular_function	oxidoreductase activity
AX	0030964	cellular_component	NADH dehydrogenase complex
AX	0031966	cellular_component	mitochondrial membrane
AX	1902600	biological_process	proton transmembrane transport
AZ	0005743	cellular_component	mitochondrial inner membrane
AZ	0005840	cellular_component	ribosome
B6	0016020	cellular_component	membrane
BH	0016491	molecular_function	oxidoreductase activity
BI	0005739	cellular_component	mitochondrion
BI	0009055	molecular_function	electron transfer activity
BI	0022900	biological_process	electron transport chain
BI	0046872	molecular_function	metal ion binding
BI	0051536	molecular_function	iron-sulfur cluster binding
BI	0051537	molecular_function	2 iron, 2 sulfur cluster binding
BI	0140647	biological_process	P450-containing electron transport chain
BR	0005739	cellular_component	mitochondrion
BR	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BR	0008270	molecular_function	zinc ion binding

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KLGLDSLDQTALLASI

Chain	Residue	Details
AV	LYS90-ILE105

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCQsACP

Chain	Residue	Details
AL	CYS136-PRO147
AL	CYS175-PRO186

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. NWEy.QYDGQWWSM

Chain	Residue	Details
BT	ASN81-MET93

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGsEKLiEdR

Chain	Residue	Details
AE	LEU62-ARG73

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtsEMYginykwKidtRkLL

Chain	Residue	Details
AO	GLU136-LEU157

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
AB	PRO62-CYS79

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
AB	CYS129-GLN141

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
AB	ARG176-PHE186

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
AD	GLU378-GLY389

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GRLQyIaDALKLFiKG

Chain	Residue	Details
AH	GLY63-GLY78

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEAEseLVt.G

Chain	Residue	Details
AH	PRO218-GLY231

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)