Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ARP

Crystal structure of DEAD-box protein Dbp2 in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0000380	biological_process	alternative mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003729	molecular_function	mRNA binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006364	biological_process	rRNA processing
A	0006369	biological_process	termination of RNA polymerase II transcription
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0010467	biological_process	gene expression
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030515	molecular_function	snoRNA binding
A	0042254	biological_process	ribosome biogenesis
A	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
A	1990904	cellular_component	ribonucleoprotein complex
B	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B	0000380	biological_process	alternative mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0003729	molecular_function	mRNA binding
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006364	biological_process	rRNA processing
B	0006369	biological_process	termination of RNA polymerase II transcription
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0010467	biological_process	gene expression
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030515	molecular_function	snoRNA binding
B	0042254	biological_process	ribosome biogenesis
B	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
B	1990904	cellular_component	ribonucleoprotein complex
C	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C	0000380	biological_process	alternative mRNA splicing, via spliceosome
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003724	molecular_function	RNA helicase activity
C	0003729	molecular_function	mRNA binding
C	0004386	molecular_function	helicase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006364	biological_process	rRNA processing
C	0006369	biological_process	termination of RNA polymerase II transcription
C	0008186	molecular_function	ATP-dependent activity, acting on RNA
C	0010467	biological_process	gene expression
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030515	molecular_function	snoRNA binding
C	0042254	biological_process	ribosome biogenesis
C	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
C	1990904	cellular_component	ribonucleoprotein complex
D	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D	0000380	biological_process	alternative mRNA splicing, via spliceosome
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0003729	molecular_function	mRNA binding
D	0004386	molecular_function	helicase activity
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0006364	biological_process	rRNA processing
D	0006369	biological_process	termination of RNA polymerase II transcription
D	0008186	molecular_function	ATP-dependent activity, acting on RNA
D	0010467	biological_process	gene expression
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030515	molecular_function	snoRNA binding
D	0042254	biological_process	ribosome biogenesis
D	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
D	1990904	cellular_component	ribonucleoprotein complex
E	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
E	0000380	biological_process	alternative mRNA splicing, via spliceosome
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0003724	molecular_function	RNA helicase activity
E	0003729	molecular_function	mRNA binding
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0006364	biological_process	rRNA processing
E	0006369	biological_process	termination of RNA polymerase II transcription
E	0008186	molecular_function	ATP-dependent activity, acting on RNA
E	0010467	biological_process	gene expression
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030515	molecular_function	snoRNA binding
E	0042254	biological_process	ribosome biogenesis
E	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
E	1990904	cellular_component	ribonucleoprotein complex
F	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
F	0000380	biological_process	alternative mRNA splicing, via spliceosome
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0003724	molecular_function	RNA helicase activity
F	0003729	molecular_function	mRNA binding
F	0004386	molecular_function	helicase activity
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0006364	biological_process	rRNA processing
F	0006369	biological_process	termination of RNA polymerase II transcription
F	0008186	molecular_function	ATP-dependent activity, acting on RNA
F	0010467	biological_process	gene expression
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030515	molecular_function	snoRNA binding
F	0042254	biological_process	ribosome biogenesis
F	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
F	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL

Chain	Residue	Details
A	VAL265-LEU273

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	ALA157
B	ALA157
C	ALA157
D	ALA157
E	ALA157
F	ALA157

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269\|PubMed:33856219

Chain	Residue	Details
A	ARG18
B	ARG18
C	ARG18
D	ARG18
E	ARG18
F	ARG18

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269\|PubMed:26046779, ECO:0000269\|PubMed:33856219

Chain	Residue	Details
A	ARG43
B	ARG43
C	ARG43
D	ARG43
E	ARG43
F	ARG43

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
A	SER88
B	SER88
C	SER88
D	SER88
E	SER88
F	SER88

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
A	SER90
B	SER90
C	SER90
D	SER90
E	SER90
F	SER90

site_id	SWS_FT_FI6
Number of Residues	24
Details	MOD_RES: Omega-N-methylarginine; alternate => ECO:0000269\|PubMed:26046779, ECO:0000269\|PubMed:33856219

Chain	Residue	Details
A	ARG509
A	ARG512
A	ARG518
A	ARG525
B	ARG509
B	ARG512
B	ARG518
B	ARG525
C	ARG509
C	ARG512
C	ARG518
C	ARG525
D	ARG509
D	ARG512
D	ARG518
D	ARG525
E	ARG509
E	ARG512
E	ARG518
E	ARG525
F	ARG509
F	ARG512
F	ARG518
F	ARG525

site_id	SWS_FT_FI7
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
A	LYS474
B	LYS474
C	LYS474
D	LYS474
E	LYS474
F	LYS474

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)