8AOV

CryoEM structure of the Chikungunya virus nsP1 capping pores in complex with GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
A	0008174	molecular_function	mRNA methyltransferase activity
A	0016556	biological_process	mRNA modification
C	0003723	molecular_function	RNA binding
C	0006396	biological_process	RNA processing
C	0008174	molecular_function	mRNA methyltransferase activity
C	0016556	biological_process	mRNA modification
E	0003723	molecular_function	RNA binding
E	0006396	biological_process	RNA processing
E	0008174	molecular_function	mRNA methyltransferase activity
E	0016556	biological_process	mRNA modification
G	0003723	molecular_function	RNA binding
G	0006396	biological_process	RNA processing
G	0008174	molecular_function	mRNA methyltransferase activity
G	0016556	biological_process	mRNA modification
I	0003723	molecular_function	RNA binding
I	0006396	biological_process	RNA processing
I	0008174	molecular_function	mRNA methyltransferase activity
I	0016556	biological_process	mRNA modification
K	0003723	molecular_function	RNA binding
K	0006396	biological_process	RNA processing
K	0008174	molecular_function	mRNA methyltransferase activity
K	0016556	biological_process	mRNA modification
M	0003723	molecular_function	RNA binding
M	0006396	biological_process	RNA processing
M	0008174	molecular_function	mRNA methyltransferase activity
M	0016556	biological_process	mRNA modification
O	0003723	molecular_function	RNA binding
O	0006396	biological_process	RNA processing
O	0008174	molecular_function	mRNA methyltransferase activity
O	0016556	biological_process	mRNA modification
Q	0003723	molecular_function	RNA binding
Q	0006396	biological_process	RNA processing
Q	0008174	molecular_function	mRNA methyltransferase activity
Q	0016556	biological_process	mRNA modification
S	0003723	molecular_function	RNA binding
S	0006396	biological_process	RNA processing
S	0008174	molecular_function	mRNA methyltransferase activity
S	0016556	biological_process	mRNA modification
V	0003723	molecular_function	RNA binding
V	0006396	biological_process	RNA processing
V	0008174	molecular_function	mRNA methyltransferase activity
V	0016556	biological_process	mRNA modification
X	0003723	molecular_function	RNA binding
X	0006396	biological_process	RNA processing
X	0008174	molecular_function	mRNA methyltransferase activity
X	0016556	biological_process	mRNA modification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For mRNA-capping enzyme nsP1 activity => ECO:0000269|PubMed:33730549

Chain	Residue	Details
A	HIS37
S	HIS37
V	HIS37
X	HIS37
C	HIS37
E	HIS37
G	HIS37
I	HIS37
K	HIS37
M	HIS37
O	HIS37
Q	HIS37

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:33730549

Chain	Residue	Details
A	HIS79
E	GLU129
E	CYS134
E	CYS141
G	HIS79
G	GLU129
G	CYS134
G	CYS141
I	HIS79
I	GLU129
I	CYS134
A	GLU129
I	CYS141
K	HIS79
K	GLU129
K	CYS134
K	CYS141
M	HIS79
M	GLU129
M	CYS134
M	CYS141
O	HIS79
A	CYS134
O	GLU129
O	CYS134
O	CYS141
Q	HIS79
Q	GLU129
Q	CYS134
Q	CYS141
S	HIS79
S	GLU129
S	CYS134
A	CYS141
S	CYS141
V	HIS79
V	GLU129
V	CYS134
V	CYS141
X	HIS79
X	GLU129
X	CYS134
X	CYS141
C	HIS79
C	GLU129
C	CYS134
C	CYS141
E	HIS79

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	SITE: Involved in the phosphoramide link with 7-methyl-GMP => ECO:0000250|UniProtKB:P27282

Chain	Residue	Details
A	HIS37
S	HIS37
V	HIS37
X	HIS37
C	HIS37
E	HIS37
G	HIS37
I	HIS37
K	HIS37
M	HIS37
O	HIS37
Q	HIS37

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	SITE: Cleavage; by protease nsP2 => ECO:0000250|UniProtKB:P03317

Chain	Residue	Details
A	ALA535
S	ALA535
V	ALA535
X	ALA535
C	ALA535
E	ALA535
G	ALA535
I	ALA535
K	ALA535
M	ALA535
O	ALA535
Q	ALA535

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000305|PubMed:30404808

Chain	Residue	Details
A	CYS417
I	CYS419
K	CYS417
K	CYS419
M	CYS417
M	CYS419
O	CYS417
O	CYS419
Q	CYS417
Q	CYS419
S	CYS417
A	CYS419
S	CYS419
V	CYS417
V	CYS419
X	CYS417
X	CYS419
C	CYS417
C	CYS419
E	CYS417
E	CYS419
G	CYS417
G	CYS419
I	CYS417

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