8AES

Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006307	biological_process	DNA alkylation repair
A	0006974	biological_process	DNA damage response
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
B	0003824	molecular_function	catalytic activity
B	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006307	biological_process	DNA alkylation repair
B	0006974	biological_process	DNA damage response
B	0008168	molecular_function	methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation
C	0003824	molecular_function	catalytic activity
C	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006307	biological_process	DNA alkylation repair
C	0006974	biological_process	DNA damage response
C	0008168	molecular_function	methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0032259	biological_process	methylation
D	0003824	molecular_function	catalytic activity
D	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006307	biological_process	DNA alkylation repair
D	0006974	biological_process	DNA damage response
D	0008168	molecular_function	methyltransferase activity
D	0016740	molecular_function	transferase activity
D	0032259	biological_process	methylation
E	0003824	molecular_function	catalytic activity
E	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006307	biological_process	DNA alkylation repair
E	0006974	biological_process	DNA damage response
E	0008168	molecular_function	methyltransferase activity
E	0016740	molecular_function	transferase activity
E	0032259	biological_process	methylation
F	0003824	molecular_function	catalytic activity
F	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006281	biological_process	DNA repair
F	0006307	biological_process	DNA alkylation repair
F	0006974	biological_process	DNA damage response
F	0008168	molecular_function	methyltransferase activity
F	0016740	molecular_function	transferase activity
F	0032259	biological_process	methylation
G	0003824	molecular_function	catalytic activity
G	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006307	biological_process	DNA alkylation repair
G	0006974	biological_process	DNA damage response
G	0008168	molecular_function	methyltransferase activity
G	0016740	molecular_function	transferase activity
G	0032259	biological_process	methylation
H	0003824	molecular_function	catalytic activity
H	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0006281	biological_process	DNA repair
H	0006307	biological_process	DNA alkylation repair
H	0006974	biological_process	DNA damage response
H	0008168	molecular_function	methyltransferase activity
H	0016740	molecular_function	transferase activity
H	0032259	biological_process	methylation
I	0003824	molecular_function	catalytic activity
I	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0006281	biological_process	DNA repair
I	0006307	biological_process	DNA alkylation repair
I	0006974	biological_process	DNA damage response
I	0008168	molecular_function	methyltransferase activity
I	0016740	molecular_function	transferase activity
I	0032259	biological_process	methylation
J	0003824	molecular_function	catalytic activity
J	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0006281	biological_process	DNA repair
J	0006307	biological_process	DNA alkylation repair
J	0006974	biological_process	DNA damage response
J	0008168	molecular_function	methyltransferase activity
J	0016740	molecular_function	transferase activity
J	0032259	biological_process	methylation

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVI

Chain	Residue	Details
A	ILE117-ILE123

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Nucleophile; methyl group acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00772","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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