8A4C

Structure of human Rep15:Rab3B complex.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001881	biological_process	receptor recycling
A	0005515	molecular_function	protein binding
A	0010008	cellular_component	endosome membrane
A	0031901	cellular_component	early endosome membrane
A	0033572	biological_process	transferrin transport
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0055037	cellular_component	recycling endosome
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006887	biological_process	exocytosis
B	0008021	cellular_component	synaptic vesicle
B	0015031	biological_process	protein transport
B	0016787	molecular_function	hydrolase activity
B	0017157	biological_process	regulation of exocytosis
B	0019003	molecular_function	GDP binding
B	0019882	biological_process	antigen processing and presentation
B	0030141	cellular_component	secretory granule
B	0030672	cellular_component	synaptic vesicle membrane
B	0030742	molecular_function	GTP-dependent protein binding
B	0031489	molecular_function	myosin V binding
B	0031982	cellular_component	vesicle
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051586	biological_process	positive regulation of dopamine uptake involved in synaptic transmission
B	0070062	cellular_component	extracellular exosome
B	0097494	biological_process	regulation of vesicle size
B	0098691	cellular_component	dopaminergic synapse
B	0098693	biological_process	regulation of synaptic vesicle cycle
C	0001881	biological_process	receptor recycling
C	0005515	molecular_function	protein binding
C	0010008	cellular_component	endosome membrane
C	0031901	cellular_component	early endosome membrane
C	0033572	biological_process	transferrin transport
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0055037	cellular_component	recycling endosome
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0006887	biological_process	exocytosis
D	0008021	cellular_component	synaptic vesicle
D	0015031	biological_process	protein transport
D	0016787	molecular_function	hydrolase activity
D	0017157	biological_process	regulation of exocytosis
D	0019003	molecular_function	GDP binding
D	0019882	biological_process	antigen processing and presentation
D	0030141	cellular_component	secretory granule
D	0030672	cellular_component	synaptic vesicle membrane
D	0030742	molecular_function	GTP-dependent protein binding
D	0031489	molecular_function	myosin V binding
D	0031982	cellular_component	vesicle
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051586	biological_process	positive regulation of dopamine uptake involved in synaptic transmission
D	0070062	cellular_component	extracellular exosome
D	0097494	biological_process	regulation of vesicle size
D	0098691	cellular_component	dopaminergic synapse
D	0098693	biological_process	regulation of synaptic vesicle cycle

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"35871249","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8A4B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"35871249","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8A4B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35871249","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8A4B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35871249","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8A4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8A4C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"8A4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8A4C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB3B GTPase bound with GDP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3DZ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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