8A1S

Structure of murine perforin-2 (Mpeg1) pore in twisted form

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0002468	biological_process	dendritic cell antigen processing and presentation
A	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
A	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
A	0022829	molecular_function	wide pore channel activity
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0036019	cellular_component	endolysosome
A	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0045335	cellular_component	phagocytic vesicle
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0055085	biological_process	transmembrane transport
A	0061474	cellular_component	phagolysosome membrane
A	0140367	biological_process	antibacterial innate immune response
A	0140911	molecular_function	pore-forming activity
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0002468	biological_process	dendritic cell antigen processing and presentation
B	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
B	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
B	0022829	molecular_function	wide pore channel activity
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0036019	cellular_component	endolysosome
B	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
B	0042742	biological_process	defense response to bacterium
B	0045087	biological_process	innate immune response
B	0045335	cellular_component	phagocytic vesicle
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0055085	biological_process	transmembrane transport
B	0061474	cellular_component	phagolysosome membrane
B	0140367	biological_process	antibacterial innate immune response
B	0140911	molecular_function	pore-forming activity
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0002468	biological_process	dendritic cell antigen processing and presentation
C	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
C	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
C	0022829	molecular_function	wide pore channel activity
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0030670	cellular_component	phagocytic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0036019	cellular_component	endolysosome
C	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
C	0042742	biological_process	defense response to bacterium
C	0045087	biological_process	innate immune response
C	0045335	cellular_component	phagocytic vesicle
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0055085	biological_process	transmembrane transport
C	0061474	cellular_component	phagolysosome membrane
C	0140367	biological_process	antibacterial innate immune response
C	0140911	molecular_function	pore-forming activity
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0002468	biological_process	dendritic cell antigen processing and presentation
D	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
D	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
D	0022829	molecular_function	wide pore channel activity
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0036019	cellular_component	endolysosome
D	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
D	0042742	biological_process	defense response to bacterium
D	0045087	biological_process	innate immune response
D	0045335	cellular_component	phagocytic vesicle
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0055085	biological_process	transmembrane transport
D	0061474	cellular_component	phagolysosome membrane
D	0140367	biological_process	antibacterial innate immune response
D	0140911	molecular_function	pore-forming activity
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0002468	biological_process	dendritic cell antigen processing and presentation
E	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
E	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
E	0022829	molecular_function	wide pore channel activity
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0036019	cellular_component	endolysosome
E	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
E	0042742	biological_process	defense response to bacterium
E	0045087	biological_process	innate immune response
E	0045335	cellular_component	phagocytic vesicle
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0055085	biological_process	transmembrane transport
E	0061474	cellular_component	phagolysosome membrane
E	0140367	biological_process	antibacterial innate immune response
E	0140911	molecular_function	pore-forming activity
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0002468	biological_process	dendritic cell antigen processing and presentation
F	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
F	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
F	0022829	molecular_function	wide pore channel activity
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0036019	cellular_component	endolysosome
F	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
F	0042742	biological_process	defense response to bacterium
F	0045087	biological_process	innate immune response
F	0045335	cellular_component	phagocytic vesicle
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0055085	biological_process	transmembrane transport
F	0061474	cellular_component	phagolysosome membrane
F	0140367	biological_process	antibacterial innate immune response
F	0140911	molecular_function	pore-forming activity
G	0002250	biological_process	adaptive immune response
G	0002376	biological_process	immune system process
G	0002468	biological_process	dendritic cell antigen processing and presentation
G	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
G	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
G	0022829	molecular_function	wide pore channel activity
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0036019	cellular_component	endolysosome
G	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
G	0042742	biological_process	defense response to bacterium
G	0045087	biological_process	innate immune response
G	0045335	cellular_component	phagocytic vesicle
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0055085	biological_process	transmembrane transport
G	0061474	cellular_component	phagolysosome membrane
G	0140367	biological_process	antibacterial innate immune response
G	0140911	molecular_function	pore-forming activity
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0002468	biological_process	dendritic cell antigen processing and presentation
H	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
H	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
H	0022829	molecular_function	wide pore channel activity
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0036019	cellular_component	endolysosome
H	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
H	0042742	biological_process	defense response to bacterium
H	0045087	biological_process	innate immune response
H	0045335	cellular_component	phagocytic vesicle
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0055085	biological_process	transmembrane transport
H	0061474	cellular_component	phagolysosome membrane
H	0140367	biological_process	antibacterial innate immune response
H	0140911	molecular_function	pore-forming activity
I	0002250	biological_process	adaptive immune response
I	0002376	biological_process	immune system process
I	0002468	biological_process	dendritic cell antigen processing and presentation
I	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
I	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
I	0022829	molecular_function	wide pore channel activity
I	0030659	cellular_component	cytoplasmic vesicle membrane
I	0030670	cellular_component	phagocytic vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0036019	cellular_component	endolysosome
I	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
I	0042742	biological_process	defense response to bacterium
I	0045087	biological_process	innate immune response
I	0045335	cellular_component	phagocytic vesicle
I	0050829	biological_process	defense response to Gram-negative bacterium
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0055085	biological_process	transmembrane transport
I	0061474	cellular_component	phagolysosome membrane
I	0140367	biological_process	antibacterial innate immune response
I	0140911	molecular_function	pore-forming activity
J	0002250	biological_process	adaptive immune response
J	0002376	biological_process	immune system process
J	0002468	biological_process	dendritic cell antigen processing and presentation
J	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
J	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
J	0022829	molecular_function	wide pore channel activity
J	0030659	cellular_component	cytoplasmic vesicle membrane
J	0030670	cellular_component	phagocytic vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0036019	cellular_component	endolysosome
J	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
J	0042742	biological_process	defense response to bacterium
J	0045087	biological_process	innate immune response
J	0045335	cellular_component	phagocytic vesicle
J	0050829	biological_process	defense response to Gram-negative bacterium
J	0050830	biological_process	defense response to Gram-positive bacterium
J	0055085	biological_process	transmembrane transport
J	0061474	cellular_component	phagolysosome membrane
J	0140367	biological_process	antibacterial innate immune response
J	0140911	molecular_function	pore-forming activity
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0002468	biological_process	dendritic cell antigen processing and presentation
K	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
K	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
K	0022829	molecular_function	wide pore channel activity
K	0030659	cellular_component	cytoplasmic vesicle membrane
K	0030670	cellular_component	phagocytic vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0036019	cellular_component	endolysosome
K	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
K	0042742	biological_process	defense response to bacterium
K	0045087	biological_process	innate immune response
K	0045335	cellular_component	phagocytic vesicle
K	0050829	biological_process	defense response to Gram-negative bacterium
K	0050830	biological_process	defense response to Gram-positive bacterium
K	0055085	biological_process	transmembrane transport
K	0061474	cellular_component	phagolysosome membrane
K	0140367	biological_process	antibacterial innate immune response
K	0140911	molecular_function	pore-forming activity
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0002468	biological_process	dendritic cell antigen processing and presentation
L	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
L	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
L	0022829	molecular_function	wide pore channel activity
L	0030659	cellular_component	cytoplasmic vesicle membrane
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0036019	cellular_component	endolysosome
L	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
L	0042742	biological_process	defense response to bacterium
L	0045087	biological_process	innate immune response
L	0045335	cellular_component	phagocytic vesicle
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0055085	biological_process	transmembrane transport
L	0061474	cellular_component	phagolysosome membrane
L	0140367	biological_process	antibacterial innate immune response
L	0140911	molecular_function	pore-forming activity
M	0002250	biological_process	adaptive immune response
M	0002376	biological_process	immune system process
M	0002468	biological_process	dendritic cell antigen processing and presentation
M	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
M	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
M	0022829	molecular_function	wide pore channel activity
M	0030659	cellular_component	cytoplasmic vesicle membrane
M	0030670	cellular_component	phagocytic vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0036019	cellular_component	endolysosome
M	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
M	0042742	biological_process	defense response to bacterium
M	0045087	biological_process	innate immune response
M	0045335	cellular_component	phagocytic vesicle
M	0050829	biological_process	defense response to Gram-negative bacterium
M	0050830	biological_process	defense response to Gram-positive bacterium
M	0055085	biological_process	transmembrane transport
M	0061474	cellular_component	phagolysosome membrane
M	0140367	biological_process	antibacterial innate immune response
M	0140911	molecular_function	pore-forming activity
N	0002250	biological_process	adaptive immune response
N	0002376	biological_process	immune system process
N	0002468	biological_process	dendritic cell antigen processing and presentation
N	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
N	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
N	0022829	molecular_function	wide pore channel activity
N	0030659	cellular_component	cytoplasmic vesicle membrane
N	0030670	cellular_component	phagocytic vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0036019	cellular_component	endolysosome
N	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
N	0042742	biological_process	defense response to bacterium
N	0045087	biological_process	innate immune response
N	0045335	cellular_component	phagocytic vesicle
N	0050829	biological_process	defense response to Gram-negative bacterium
N	0050830	biological_process	defense response to Gram-positive bacterium
N	0055085	biological_process	transmembrane transport
N	0061474	cellular_component	phagolysosome membrane
N	0140367	biological_process	antibacterial innate immune response
N	0140911	molecular_function	pore-forming activity
O	0002250	biological_process	adaptive immune response
O	0002376	biological_process	immune system process
O	0002468	biological_process	dendritic cell antigen processing and presentation
O	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
O	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
O	0022829	molecular_function	wide pore channel activity
O	0030659	cellular_component	cytoplasmic vesicle membrane
O	0030670	cellular_component	phagocytic vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0036019	cellular_component	endolysosome
O	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
O	0042742	biological_process	defense response to bacterium
O	0045087	biological_process	innate immune response
O	0045335	cellular_component	phagocytic vesicle
O	0050829	biological_process	defense response to Gram-negative bacterium
O	0050830	biological_process	defense response to Gram-positive bacterium
O	0055085	biological_process	transmembrane transport
O	0061474	cellular_component	phagolysosome membrane
O	0140367	biological_process	antibacterial innate immune response
O	0140911	molecular_function	pore-forming activity
P	0002250	biological_process	adaptive immune response
P	0002376	biological_process	immune system process
P	0002468	biological_process	dendritic cell antigen processing and presentation
P	0002478	biological_process	antigen processing and presentation of exogenous peptide antigen
P	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
P	0022829	molecular_function	wide pore channel activity
P	0030659	cellular_component	cytoplasmic vesicle membrane
P	0030670	cellular_component	phagocytic vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0036019	cellular_component	endolysosome
P	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
P	0042742	biological_process	defense response to bacterium
P	0045087	biological_process	innate immune response
P	0045335	cellular_component	phagocytic vesicle
P	0050829	biological_process	defense response to Gram-negative bacterium
P	0050830	biological_process	defense response to Gram-positive bacterium
P	0055085	biological_process	transmembrane transport
P	0061474	cellular_component	phagolysosome membrane
P	0140367	biological_process	antibacterial innate immune response
P	0140911	molecular_function	pore-forming activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	192
Details	Transmembrane: {"description":"Beta stranded; Name=TMH1","evidences":[{"source":"PubMed","id":"36245269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8A1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8A1S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	272
Details	Transmembrane: {"description":"Beta stranded; Name=TMH2","evidences":[{"source":"PubMed","id":"36245269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8A1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8A1S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5040
Details	Domain: {"description":"MACPF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00745","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32064340","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32064340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36245269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8A1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8A1S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---