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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ZR1

Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000014molecular_functionsingle-stranded DNA endodeoxyribonuclease activity
A0000723biological_processtelomere maintenance
A0000724biological_processdouble-strand break repair via homologous recombination
A0000781cellular_componentchromosome, telomeric region
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0004520molecular_functionDNA endonuclease activity
A0004527molecular_functionexonuclease activity
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006974biological_processDNA damage response
A0007095biological_processmitotic G2 DNA damage checkpoint signaling
A0008296molecular_function3'-5'-DNA exonuclease activity
A0016787molecular_functionhydrolase activity
A0030145molecular_functionmanganese ion binding
A0030870cellular_componentMre11 complex
A0031573biological_processmitotic intra-S DNA damage checkpoint signaling
A0035861cellular_componentsite of double-strand break
A0042138biological_processmeiotic DNA double-strand break formation
A0046872molecular_functionmetal ion binding
A0051321biological_processmeiotic cell cycle
A0097552biological_processmitochondrial double-strand break repair via homologous recombination
B0000014molecular_functionsingle-stranded DNA endodeoxyribonuclease activity
B0000723biological_processtelomere maintenance
B0000724biological_processdouble-strand break repair via homologous recombination
B0000781cellular_componentchromosome, telomeric region
B0004518molecular_functionnuclease activity
B0004519molecular_functionendonuclease activity
B0004520molecular_functionDNA endonuclease activity
B0004527molecular_functionexonuclease activity
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006974biological_processDNA damage response
B0007095biological_processmitotic G2 DNA damage checkpoint signaling
B0008296molecular_function3'-5'-DNA exonuclease activity
B0016787molecular_functionhydrolase activity
B0030145molecular_functionmanganese ion binding
B0030870cellular_componentMre11 complex
B0031573biological_processmitotic intra-S DNA damage checkpoint signaling
B0035861cellular_componentsite of double-strand break
B0042138biological_processmeiotic DNA double-strand break formation
B0046872molecular_functionmetal ion binding
B0051321biological_processmeiotic cell cycle
B0097552biological_processmitochondrial double-strand break repair via homologous recombination
C0000722biological_processtelomere maintenance via recombination
C0000723biological_processtelomere maintenance
C0000794cellular_componentcondensed nuclear chromosome
C0003677molecular_functionDNA binding
C0003690molecular_functiondouble-stranded DNA binding
C0003691molecular_functiondouble-stranded telomeric DNA binding
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0006281biological_processDNA repair
C0006302biological_processdouble-strand break repair
C0006974biological_processDNA damage response
C0007004biological_processtelomere maintenance via telomerase
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0030870cellular_componentMre11 complex
C0043047molecular_functionsingle-stranded telomeric DNA binding
C0046872molecular_functionmetal ion binding
C0051880molecular_functionG-quadruplex DNA binding
C0070192biological_processchromosome organization involved in meiotic cell cycle
D0000722biological_processtelomere maintenance via recombination
D0000723biological_processtelomere maintenance
D0000794cellular_componentcondensed nuclear chromosome
D0003677molecular_functionDNA binding
D0003690molecular_functiondouble-stranded DNA binding
D0003691molecular_functiondouble-stranded telomeric DNA binding
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0006281biological_processDNA repair
D0006302biological_processdouble-strand break repair
D0006974biological_processDNA damage response
D0007004biological_processtelomere maintenance via telomerase
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0030870cellular_componentMre11 complex
D0043047molecular_functionsingle-stranded telomeric DNA binding
D0046872molecular_functionmetal ion binding
D0051880molecular_functionG-quadruplex DNA binding
D0070192biological_processchromosome organization involved in meiotic cell cycle
E0000724biological_processdouble-strand break repair via homologous recombination
E0003684molecular_functiondamaged DNA binding
E0005634cellular_componentnucleus
E0005694cellular_componentchromosome
E0006281biological_processDNA repair
E0006302biological_processdouble-strand break repair
E0006974biological_processDNA damage response
E0007095biological_processmitotic G2 DNA damage checkpoint signaling
E0030870cellular_componentMre11 complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DPSGDGHLCslDL
ChainResidueDetails
AASP127-LEU139
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PIRSR","id":"PIRSR000882-1","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26057807","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36577401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZR1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues70
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues354
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26896444","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5DA9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DAC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26896444","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DA9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DAC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues14
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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