7ZGJ

Trypanosoma brucei gambiense ISG65 in complex with human complement component C3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006954	biological_process	inflammatory response
B	0006956	biological_process	complement activation

Functional Information from PROSITE/UniProt

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM

Chain	Residue	Details
B	PRO1007-MET1015

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site_id	PS01177
Number of Residues	36
Details	ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCedGmrenpmrfSCQrrtrfisl.GeaCkkvfld.CC

Chain	Residue	Details
B	CYS693-CYS728

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by carboxypeptidases

Chain	Residue	Details
B	ALA747

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by C3 convertase

Chain	Residue	Details
B	ARG748
A	SER70
A	SER297
A	SER303

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by factor I => ECO:0000255

Chain	Residue	Details
B	ARG954

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cleavage; by factor I

Chain	Residue	Details
B	ARG1303
B	ARG1320

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604

Chain	Residue	Details
B	ASN1663

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site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
B	SER672
B	SER968
B	SER1321
B	SER1573

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150

Chain	Residue	Details
B	ASN939

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
B	ASN1617

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
B	CYS1010
B	GLN1013

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