7ZDM

Complex I from Ovis aries at pH5.5, Closed state

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005739	cellular_component	mitochondrion
1	0005743	cellular_component	mitochondrial inner membrane
1	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0010181	molecular_function	FMN binding
1	0045271	cellular_component	respiratory chain complex I
1	0046872	molecular_function	metal ion binding
1	0051287	molecular_function	NAD binding
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1	0070469	cellular_component	respirasome
1	1902600	biological_process	proton transmembrane transport
2	0003954	molecular_function	NADH dehydrogenase activity
2	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
2	0016491	molecular_function	oxidoreductase activity
2	0045271	cellular_component	respiratory chain complex I
2	0046872	molecular_function	metal ion binding
2	0051537	molecular_function	2 iron, 2 sulfur cluster binding
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0016491	molecular_function	oxidoreductase activity
3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
3	0042773	biological_process	ATP synthesis coupled electron transport
3	0051536	molecular_function	iron-sulfur cluster binding
4	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
4	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0051287	molecular_function	NAD binding
4	0051539	molecular_function	4 iron, 4 sulfur cluster binding
4	0070469	cellular_component	respirasome
5	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
5	1902600	biological_process	proton transmembrane transport
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0046872	molecular_function	metal ion binding
6	0048038	molecular_function	quinone binding
6	0051536	molecular_function	iron-sulfur cluster binding
6	0051539	molecular_function	4 iron, 4 sulfur cluster binding
6	1902600	biological_process	proton transmembrane transport
9	0003954	molecular_function	NADH dehydrogenase activity
9	0005739	cellular_component	mitochondrion
9	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
9	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
9	0016020	cellular_component	membrane
9	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
9	0032981	biological_process	mitochondrial respiratory chain complex I assembly
9	0051539	molecular_function	4 iron, 4 sulfur cluster binding
a	0005739	cellular_component	mitochondrion
a	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
a	0016020	cellular_component	membrane
a	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0070469	cellular_component	respirasome
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0022900	biological_process	electron transport chain
c	0070469	cellular_component	respirasome
d	0003954	molecular_function	NADH dehydrogenase activity
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
d	0005759	cellular_component	mitochondrial matrix
d	0007623	biological_process	circadian rhythm
d	0031966	cellular_component	mitochondrial membrane
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0044877	molecular_function	protein-containing complex binding
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
e	0070469	cellular_component	respirasome
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
f	0022904	biological_process	respiratory electron transport chain
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
g	0006979	biological_process	response to oxidative stress
g	0031966	cellular_component	mitochondrial membrane
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0070469	cellular_component	respirasome
h	0005743	cellular_component	mitochondrial inner membrane
h	0016020	cellular_component	membrane
h	0042773	biological_process	ATP synthesis coupled electron transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0031966	cellular_component	mitochondrial membrane
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
i	0006979	biological_process	response to oxidative stress
i	0016020	cellular_component	membrane
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0070469	cellular_component	respirasome
j	0000035	molecular_function	acyl binding
j	0000036	molecular_function	acyl carrier activity
j	0005739	cellular_component	mitochondrion
j	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
j	0006633	biological_process	fatty acid biosynthetic process
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0070469	cellular_component	respirasome
J	1902600	biological_process	proton transmembrane transport
k	0005737	cellular_component	cytoplasm
k	0005739	cellular_component	mitochondrion
k	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
k	0005759	cellular_component	mitochondrial matrix
k	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
k	0070469	cellular_component	respirasome
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0045271	cellular_component	respiratory chain complex I
K	0070469	cellular_component	respirasome
K	1902600	biological_process	proton transmembrane transport
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0070469	cellular_component	respirasome
m	0005743	cellular_component	mitochondrial inner membrane
m	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0070469	cellular_component	respirasome
M	1902600	biological_process	proton transmembrane transport
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
n	0022900	biological_process	electron transport chain
n	0032981	biological_process	mitochondrial respiratory chain complex I assembly
n	0070469	cellular_component	respirasome
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0070469	cellular_component	respirasome
N	0072593	biological_process	reactive oxygen species metabolic process
N	1902600	biological_process	proton transmembrane transport
o	0005737	cellular_component	cytoplasm
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0070469	cellular_component	respirasome
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
p	0016020	cellular_component	membrane
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
q	0016020	cellular_component	membrane
q	0070469	cellular_component	respirasome
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0016020	cellular_component	membrane
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
s	0005758	cellular_component	mitochondrial intermembrane space
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0016020	cellular_component	membrane
s	0032981	biological_process	mitochondrial respiratory chain complex I assembly
s	1902600	biological_process	proton transmembrane transport
t	0005739	cellular_component	mitochondrion
t	0005743	cellular_component	mitochondrial inner membrane
t	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
t	0070469	cellular_component	respirasome
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
u	0032981	biological_process	mitochondrial respiratory chain complex I assembly
v	0005739	cellular_component	mitochondrion
v	0005743	cellular_component	mitochondrial inner membrane
v	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
v	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
v	0032981	biological_process	mitochondrial respiratory chain complex I assembly
v	0070469	cellular_component	respirasome
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0032981	biological_process	mitochondrial respiratory chain complex I assembly
w	0005743	cellular_component	mitochondrial inner membrane
w	0016020	cellular_component	membrane
W	0005743	cellular_component	mitochondrial inner membrane
W	0016020	cellular_component	membrane
x	0005739	cellular_component	mitochondrion
x	0005743	cellular_component	mitochondrial inner membrane
x	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
x	0016020	cellular_component	membrane
X	0000035	molecular_function	acyl binding
X	0000036	molecular_function	acyl carrier activity
X	0005739	cellular_component	mitochondrion
X	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
X	0006633	biological_process	fatty acid biosynthetic process
y	0005739	cellular_component	mitochondrion
y	0005743	cellular_component	mitochondrial inner membrane
y	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
y	0016020	cellular_component	membrane
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Y	0005758	cellular_component	mitochondrial intermembrane space
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Y	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Y	0044877	molecular_function	protein-containing complex binding
Y	0070469	cellular_component	respirasome
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
z	0070469	cellular_component	respirasome
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0070469	cellular_component	respirasome

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
X	ASP39-MET54

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
X	ASP64-ILE76

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
9	CYS77-PRO88
9	CYS116-PRO127

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
4	LEU83-LYS94

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
5	GLU131-LEU152

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
3	PRO38-CYS55

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
3	CYS105-GLN117

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
3	ARG152-PHE162

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
1	GLY180-SER195

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
1	GLU357-GLY368

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE

Chain	Residue	Details
H	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
H	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
2	ASP134-PRO152

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
6	GLY135-PRO151

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
N	PRO3-SER23
N	ASP274-MET294
N	LEU325-ILE345
L	MET366-LEU386
L	LEU413-GLY433
L	LEU457-ILE477
L	TYR485-SER505
L	GLY582-LEU602
N	HIS25-MET45
N	SER67-MET87
N	MET96-PRO116
N	ILE122-LEU142
N	ILE145-GLY165
N	ILE178-PRO198
N	MET200-MET220
N	ALA237-LEU257

---