Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Z8I

The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2)

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0003779	molecular_function	actin binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0008290	cellular_component	F-actin capping protein complex
K	0051016	biological_process	barbed-end actin filament capping
K	0051693	biological_process	actin filament capping
L	0003779	molecular_function	actin binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0007010	biological_process	cytoskeleton organization
L	0008290	cellular_component	F-actin capping protein complex
L	0022604	biological_process	regulation of cell morphogenesis
L	0030017	cellular_component	sarcomere
L	0030036	biological_process	actin cytoskeleton organization
L	0051016	biological_process	barbed-end actin filament capping
L	0051693	biological_process	actin filament capping
L	0071203	cellular_component	WASH complex
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005813	cellular_component	centrosome
X	0005856	cellular_component	cytoskeleton
X	0007399	biological_process	nervous system development
X	0031175	biological_process	neuron projection development
X	0031267	molecular_function	small GTPase binding
X	0034452	molecular_function	dynactin binding
X	0047496	biological_process	vesicle transport along microtubule
X	0055107	biological_process	Golgi to secretory granule transport
f	0000166	molecular_function	nucleotide binding
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005576	cellular_component	extracellular region
f	0005737	cellular_component	cytoplasm
f	0005813	cellular_component	centrosome
f	0005829	cellular_component	cytosol
f	0005856	cellular_component	cytoskeleton
f	0005868	cellular_component	cytoplasmic dynein complex
f	0005874	cellular_component	microtubule
f	0005881	cellular_component	cytoplasmic microtubule
f	0005938	cellular_component	cell cortex
f	0007018	biological_process	microtubule-based movement
f	0007052	biological_process	mitotic spindle organization
f	0007097	biological_process	nuclear migration
f	0008090	biological_process	retrograde axonal transport
f	0008569	molecular_function	minus-end-directed microtubule motor activity
f	0016020	cellular_component	membrane
f	0030175	cellular_component	filopodium
f	0030286	cellular_component	dynein complex
f	0031122	biological_process	cytoplasmic microtubule organization
f	0032388	biological_process	positive regulation of intracellular transport
f	0033962	biological_process	P-body assembly
f	0034063	biological_process	stress granule assembly
f	0035578	cellular_component	azurophil granule lumen
f	0042802	molecular_function	identical protein binding
f	0045505	molecular_function	dynein intermediate chain binding
f	0051293	biological_process	establishment of spindle localization
f	0051301	biological_process	cell division
f	0051959	molecular_function	dynein light intermediate chain binding
f	0060236	biological_process	regulation of mitotic spindle organization
f	0070062	cellular_component	extracellular exosome
f	0090235	biological_process	regulation of metaphase plate congression
f	0120162	biological_process	positive regulation of cold-induced thermogenesis
f	1904115	cellular_component	axon cytoplasm
f	1905832	biological_process	positive regulation of spindle assembly
h	0003777	molecular_function	microtubule motor activity
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005868	cellular_component	cytoplasmic dynein complex
h	0005874	cellular_component	microtubule
h	0007018	biological_process	microtubule-based movement
h	0010970	biological_process	transport along microtubule
h	0030286	cellular_component	dynein complex
h	0031982	cellular_component	vesicle
h	0032388	biological_process	positive regulation of intracellular transport
h	0045503	molecular_function	dynein light chain binding
h	0045504	molecular_function	dynein heavy chain binding
j	0000166	molecular_function	nucleotide binding
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000776	cellular_component	kinetochore
j	0005524	molecular_function	ATP binding
j	0005737	cellular_component	cytoplasm
j	0005770	cellular_component	late endosome
j	0005813	cellular_component	centrosome
j	0005829	cellular_component	cytosol
j	0005856	cellular_component	cytoskeleton
j	0005868	cellular_component	cytoplasmic dynein complex
j	0005874	cellular_component	microtubule
j	0007018	biological_process	microtubule-based movement
j	0016020	cellular_component	membrane
j	0030286	cellular_component	dynein complex
j	0032388	biological_process	positive regulation of intracellular transport
j	0042802	molecular_function	identical protein binding
j	0045504	molecular_function	dynein heavy chain binding
j	0051642	biological_process	centrosome localization
j	1990090	biological_process	cellular response to nerve growth factor stimulus
m	0000166	molecular_function	nucleotide binding
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005524	molecular_function	ATP binding
m	0005576	cellular_component	extracellular region
m	0005737	cellular_component	cytoplasm
m	0005813	cellular_component	centrosome
m	0005829	cellular_component	cytosol
m	0005856	cellular_component	cytoskeleton
m	0005868	cellular_component	cytoplasmic dynein complex
m	0005874	cellular_component	microtubule
m	0005881	cellular_component	cytoplasmic microtubule
m	0005938	cellular_component	cell cortex
m	0007018	biological_process	microtubule-based movement
m	0007052	biological_process	mitotic spindle organization
m	0007097	biological_process	nuclear migration
m	0008090	biological_process	retrograde axonal transport
m	0008569	molecular_function	minus-end-directed microtubule motor activity
m	0016020	cellular_component	membrane
m	0030175	cellular_component	filopodium
m	0030286	cellular_component	dynein complex
m	0031122	biological_process	cytoplasmic microtubule organization
m	0032388	biological_process	positive regulation of intracellular transport
m	0033962	biological_process	P-body assembly
m	0034063	biological_process	stress granule assembly
m	0035578	cellular_component	azurophil granule lumen
m	0042802	molecular_function	identical protein binding
m	0045505	molecular_function	dynein intermediate chain binding
m	0051293	biological_process	establishment of spindle localization
m	0051301	biological_process	cell division
m	0051959	molecular_function	dynein light intermediate chain binding
m	0060236	biological_process	regulation of mitotic spindle organization
m	0070062	cellular_component	extracellular exosome
m	0090235	biological_process	regulation of metaphase plate congression
m	0120162	biological_process	positive regulation of cold-induced thermogenesis
m	1904115	cellular_component	axon cytoplasm
m	1905832	biological_process	positive regulation of spindle assembly
n	0000166	molecular_function	nucleotide binding
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005524	molecular_function	ATP binding
n	0005576	cellular_component	extracellular region
n	0005737	cellular_component	cytoplasm
n	0005813	cellular_component	centrosome
n	0005829	cellular_component	cytosol
n	0005856	cellular_component	cytoskeleton
n	0005868	cellular_component	cytoplasmic dynein complex
n	0005874	cellular_component	microtubule
n	0005881	cellular_component	cytoplasmic microtubule
n	0005938	cellular_component	cell cortex
n	0007018	biological_process	microtubule-based movement
n	0007052	biological_process	mitotic spindle organization
n	0007097	biological_process	nuclear migration
n	0008090	biological_process	retrograde axonal transport
n	0008569	molecular_function	minus-end-directed microtubule motor activity
n	0016020	cellular_component	membrane
n	0030175	cellular_component	filopodium
n	0030286	cellular_component	dynein complex
n	0031122	biological_process	cytoplasmic microtubule organization
n	0032388	biological_process	positive regulation of intracellular transport
n	0033962	biological_process	P-body assembly
n	0034063	biological_process	stress granule assembly
n	0035578	cellular_component	azurophil granule lumen
n	0042802	molecular_function	identical protein binding
n	0045505	molecular_function	dynein intermediate chain binding
n	0051293	biological_process	establishment of spindle localization
n	0051301	biological_process	cell division
n	0051959	molecular_function	dynein light intermediate chain binding
n	0060236	biological_process	regulation of mitotic spindle organization
n	0070062	cellular_component	extracellular exosome
n	0090235	biological_process	regulation of metaphase plate congression
n	0120162	biological_process	positive regulation of cold-induced thermogenesis
n	1904115	cellular_component	axon cytoplasm
n	1905832	biological_process	positive regulation of spindle assembly
o	0003777	molecular_function	microtubule motor activity
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0005813	cellular_component	centrosome
o	0005829	cellular_component	cytosol
o	0005856	cellular_component	cytoskeleton
o	0005868	cellular_component	cytoplasmic dynein complex
o	0005874	cellular_component	microtubule
o	0007018	biological_process	microtubule-based movement
o	0010970	biological_process	transport along microtubule
o	0030286	cellular_component	dynein complex
o	0031982	cellular_component	vesicle
o	0032388	biological_process	positive regulation of intracellular transport
o	0045503	molecular_function	dynein light chain binding
o	0045504	molecular_function	dynein heavy chain binding
r	0000166	molecular_function	nucleotide binding
r	0000226	biological_process	microtubule cytoskeleton organization
r	0000776	cellular_component	kinetochore
r	0005524	molecular_function	ATP binding
r	0005737	cellular_component	cytoplasm
r	0005770	cellular_component	late endosome
r	0005813	cellular_component	centrosome
r	0005829	cellular_component	cytosol
r	0005856	cellular_component	cytoskeleton
r	0005868	cellular_component	cytoplasmic dynein complex
r	0005874	cellular_component	microtubule
r	0007018	biological_process	microtubule-based movement
r	0016020	cellular_component	membrane
r	0030286	cellular_component	dynein complex
r	0032388	biological_process	positive regulation of intracellular transport
r	0042802	molecular_function	identical protein binding
r	0045504	molecular_function	dynein heavy chain binding
r	0051642	biological_process	centrosome localization
r	1990090	biological_process	cellular response to nerve growth factor stimulus
x	0005515	molecular_function	protein binding
x	0005737	cellular_component	cytoplasm
x	0005813	cellular_component	centrosome
x	0005856	cellular_component	cytoskeleton
x	0007399	biological_process	nervous system development
x	0031175	biological_process	neuron projection development
x	0031267	molecular_function	small GTPase binding
x	0034452	molecular_function	dynactin binding
x	0047496	biological_process	vesicle transport along microtubule
x	0055107	biological_process	Golgi to secretory granule transport

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
L	CYS62-ASP67

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WVSKkEYEE

Chain	Residue	Details
A	TRP357-GLU365

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
f	ILE2216-SER2226

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
K	VAL196-VAL204

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
K	LYS256-ARG266

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR

Chain	Residue	Details
A	LEU109-ARG121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
j	GLY61
n	GLY2224
n	GLY2595
n	GLY2937
r	GLY61
f	GLY2595
f	GLY2937
m	GLY1906
m	GLY2224
m	GLY2595
m	GLY2937
n	GLY1906

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
j	SER194
r	SER194
n	SER2

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
j	SER383
r	SER383
m	SER70
m	SER4162
n	SER70
n	SER4162

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
j	SER391
r	SER391
f	LYS4283
m	LYS1125
m	LYS3480
m	LYS4283
n	LYS1125
n	LYS3480
n	LYS4283

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
j	ARG397
r	ARG397
n	SER1230

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
j	THR441
r	THR441
n	THR4366

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
j	SER443
r	SER443
n	SER4368

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
j	SER446
r	SER446

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)