7Z8I

The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2)

Functional Information from GO Data

Chain	GOid	namespace	contents
f	0001673	cellular_component	male germ cell nucleus
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005576	cellular_component	extracellular region
f	0005737	cellular_component	cytoplasm
f	0005813	cellular_component	centrosome
f	0005829	cellular_component	cytosol
f	0005856	cellular_component	cytoskeleton
f	0005868	cellular_component	cytoplasmic dynein complex
f	0005874	cellular_component	microtubule
f	0005881	cellular_component	cytoplasmic microtubule
f	0005938	cellular_component	cell cortex
f	0007018	biological_process	microtubule-based movement
f	0007052	biological_process	mitotic spindle organization
f	0007097	biological_process	nuclear migration
f	0008090	biological_process	retrograde axonal transport
f	0008569	molecular_function	minus-end-directed microtubule motor activity
f	0016020	cellular_component	membrane
f	0030175	cellular_component	filopodium
f	0030286	cellular_component	dynein complex
f	0031122	biological_process	cytoplasmic microtubule organization
f	0032388	biological_process	positive regulation of intracellular transport
f	0033962	biological_process	P-body assembly
f	0034063	biological_process	stress granule assembly
f	0035578	cellular_component	azurophil granule lumen
f	0042802	molecular_function	identical protein binding
f	0045505	molecular_function	dynein intermediate chain binding
f	0051293	biological_process	establishment of spindle localization
f	0051959	molecular_function	dynein light intermediate chain binding
f	0060236	biological_process	regulation of mitotic spindle organization
f	0070062	cellular_component	extracellular exosome
f	0090235	biological_process	regulation of metaphase plate congression
f	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
f	0120162	biological_process	positive regulation of cold-induced thermogenesis
f	1904115	cellular_component	axon cytoplasm
f	1905832	biological_process	positive regulation of spindle assembly
h	0001673	cellular_component	male germ cell nucleus
h	0003777	molecular_function	microtubule motor activity
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005868	cellular_component	cytoplasmic dynein complex
h	0005874	cellular_component	microtubule
h	0007018	biological_process	microtubule-based movement
h	0010970	biological_process	transport along microtubule
h	0031982	cellular_component	vesicle
h	0032388	biological_process	positive regulation of intracellular transport
h	0036157	cellular_component	outer dynein arm
h	0045503	molecular_function	dynein light chain binding
h	0045504	molecular_function	dynein heavy chain binding
h	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000776	cellular_component	kinetochore
j	0001673	cellular_component	male germ cell nucleus
j	0005770	cellular_component	late endosome
j	0005813	cellular_component	centrosome
j	0005829	cellular_component	cytosol
j	0005856	cellular_component	cytoskeleton
j	0005868	cellular_component	cytoplasmic dynein complex
j	0007018	biological_process	microtubule-based movement
j	0016020	cellular_component	membrane
j	0032388	biological_process	positive regulation of intracellular transport
j	0042802	molecular_function	identical protein binding
j	0045504	molecular_function	dynein heavy chain binding
j	1990090	biological_process	cellular response to nerve growth factor stimulus
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0008290	cellular_component	F-actin capping protein complex
K	0051016	biological_process	barbed-end actin filament capping
L	0003779	molecular_function	actin binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0008290	cellular_component	F-actin capping protein complex
L	0015629	cellular_component	actin cytoskeleton
L	0030017	cellular_component	sarcomere
L	0030036	biological_process	actin cytoskeleton organization
L	0030989	biological_process	dynein-driven meiotic oscillatory nuclear movement
L	0051016	biological_process	barbed-end actin filament capping
L	0071203	cellular_component	WASH complex
m	0001673	cellular_component	male germ cell nucleus
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005524	molecular_function	ATP binding
m	0005576	cellular_component	extracellular region
m	0005737	cellular_component	cytoplasm
m	0005813	cellular_component	centrosome
m	0005829	cellular_component	cytosol
m	0005856	cellular_component	cytoskeleton
m	0005868	cellular_component	cytoplasmic dynein complex
m	0005874	cellular_component	microtubule
m	0005881	cellular_component	cytoplasmic microtubule
m	0005938	cellular_component	cell cortex
m	0007018	biological_process	microtubule-based movement
m	0007052	biological_process	mitotic spindle organization
m	0007097	biological_process	nuclear migration
m	0008090	biological_process	retrograde axonal transport
m	0008569	molecular_function	minus-end-directed microtubule motor activity
m	0016020	cellular_component	membrane
m	0030175	cellular_component	filopodium
m	0030286	cellular_component	dynein complex
m	0031122	biological_process	cytoplasmic microtubule organization
m	0032388	biological_process	positive regulation of intracellular transport
m	0033962	biological_process	P-body assembly
m	0034063	biological_process	stress granule assembly
m	0035578	cellular_component	azurophil granule lumen
m	0042802	molecular_function	identical protein binding
m	0045505	molecular_function	dynein intermediate chain binding
m	0051293	biological_process	establishment of spindle localization
m	0051959	molecular_function	dynein light intermediate chain binding
m	0060236	biological_process	regulation of mitotic spindle organization
m	0070062	cellular_component	extracellular exosome
m	0090235	biological_process	regulation of metaphase plate congression
m	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
m	0120162	biological_process	positive regulation of cold-induced thermogenesis
m	1904115	cellular_component	axon cytoplasm
m	1905832	biological_process	positive regulation of spindle assembly
n	0001673	cellular_component	male germ cell nucleus
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005524	molecular_function	ATP binding
n	0005576	cellular_component	extracellular region
n	0005737	cellular_component	cytoplasm
n	0005813	cellular_component	centrosome
n	0005829	cellular_component	cytosol
n	0005856	cellular_component	cytoskeleton
n	0005868	cellular_component	cytoplasmic dynein complex
n	0005874	cellular_component	microtubule
n	0005881	cellular_component	cytoplasmic microtubule
n	0005938	cellular_component	cell cortex
n	0007018	biological_process	microtubule-based movement
n	0007052	biological_process	mitotic spindle organization
n	0007097	biological_process	nuclear migration
n	0008090	biological_process	retrograde axonal transport
n	0008569	molecular_function	minus-end-directed microtubule motor activity
n	0016020	cellular_component	membrane
n	0030175	cellular_component	filopodium
n	0030286	cellular_component	dynein complex
n	0031122	biological_process	cytoplasmic microtubule organization
n	0032388	biological_process	positive regulation of intracellular transport
n	0033962	biological_process	P-body assembly
n	0034063	biological_process	stress granule assembly
n	0035578	cellular_component	azurophil granule lumen
n	0042802	molecular_function	identical protein binding
n	0045505	molecular_function	dynein intermediate chain binding
n	0051293	biological_process	establishment of spindle localization
n	0051959	molecular_function	dynein light intermediate chain binding
n	0060236	biological_process	regulation of mitotic spindle organization
n	0070062	cellular_component	extracellular exosome
n	0090235	biological_process	regulation of metaphase plate congression
n	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
n	0120162	biological_process	positive regulation of cold-induced thermogenesis
n	1904115	cellular_component	axon cytoplasm
n	1905832	biological_process	positive regulation of spindle assembly
o	0001673	cellular_component	male germ cell nucleus
o	0003777	molecular_function	microtubule motor activity
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0005813	cellular_component	centrosome
o	0005829	cellular_component	cytosol
o	0005856	cellular_component	cytoskeleton
o	0005868	cellular_component	cytoplasmic dynein complex
o	0005874	cellular_component	microtubule
o	0007018	biological_process	microtubule-based movement
o	0010970	biological_process	transport along microtubule
o	0031982	cellular_component	vesicle
o	0032388	biological_process	positive regulation of intracellular transport
o	0036157	cellular_component	outer dynein arm
o	0045503	molecular_function	dynein light chain binding
o	0045504	molecular_function	dynein heavy chain binding
o	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
r	0000226	biological_process	microtubule cytoskeleton organization
r	0000776	cellular_component	kinetochore
r	0001673	cellular_component	male germ cell nucleus
r	0005770	cellular_component	late endosome
r	0005813	cellular_component	centrosome
r	0005829	cellular_component	cytosol
r	0005856	cellular_component	cytoskeleton
r	0005868	cellular_component	cytoplasmic dynein complex
r	0007018	biological_process	microtubule-based movement
r	0016020	cellular_component	membrane
r	0032388	biological_process	positive regulation of intracellular transport
r	0042802	molecular_function	identical protein binding
r	0045504	molecular_function	dynein heavy chain binding
r	1990090	biological_process	cellular response to nerve growth factor stimulus
x	0005515	molecular_function	protein binding
x	0005813	cellular_component	centrosome
x	0005856	cellular_component	cytoskeleton
x	0031175	biological_process	neuron projection development
x	0031267	molecular_function	small GTPase binding
x	0034452	molecular_function	dynactin binding
x	0047496	biological_process	vesicle transport along microtubule
x	0055107	biological_process	Golgi to secretory granule transport
X	0005515	molecular_function	protein binding
X	0005813	cellular_component	centrosome
X	0005856	cellular_component	cytoskeleton
X	0031175	biological_process	neuron projection development
X	0031267	molecular_function	small GTPase binding
X	0034452	molecular_function	dynactin binding
X	0047496	biological_process	vesicle transport along microtubule
X	0055107	biological_process	Golgi to secretory granule transport

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
L	CYS62-ASP67

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WVSKkEYEE

Chain	Residue	Details
A	TRP357-GLU365

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
f	ILE2216-SER2226

---

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
K	VAL196-VAL204

---

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
K	LYS256-ARG266

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR

Chain	Residue	Details
A	LEU109-ARG121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"CC1 box","evidences":[{"source":"PubMed","id":"36071160","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	151
Details	Region: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	138
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	98
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	82
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	80
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	90
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	80
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	78
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---