7Z6H

Structure of DNA-bound human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000076	biological_process	DNA replication checkpoint signaling
A	0000077	biological_process	DNA damage checkpoint signaling
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0016787	molecular_function	hydrolase activity
A	0017124	molecular_function	SH3 domain binding
A	0019899	molecular_function	enzyme binding
A	0019901	molecular_function	protein kinase binding
A	0030896	cellular_component	checkpoint clamp complex
A	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
A	0042826	molecular_function	histone deacetylase binding
A	0071479	biological_process	cellular response to ionizing radiation
A	1902231	biological_process	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
B	0000076	biological_process	DNA replication checkpoint signaling
B	0000077	biological_process	DNA damage checkpoint signaling
B	0000166	molecular_function	nucleotide binding
B	0000781	cellular_component	chromosome, telomeric region
B	0003682	molecular_function	chromatin binding
B	0003684	molecular_function	damaged DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0006281	biological_process	DNA repair
B	0006325	biological_process	chromatin organization
B	0006974	biological_process	DNA damage response
B	0008156	biological_process	negative regulation of DNA replication
B	0021762	biological_process	substantia nigra development
B	0030896	cellular_component	checkpoint clamp complex
B	0031389	cellular_component	Rad17 RFC-like complex
B	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
B	0033314	biological_process	mitotic DNA replication checkpoint signaling
B	0035861	cellular_component	site of double-strand break
B	0042325	biological_process	regulation of phosphorylation
B	0051598	biological_process	meiotic recombination checkpoint signaling
B	0071479	biological_process	cellular response to ionizing radiation
B	0140463	molecular_function	chromatin-protein adaptor activity
B	1990166	biological_process	protein localization to site of double-strand break
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006974	biological_process	DNA damage response
C	0009314	biological_process	response to radiation
C	0009411	biological_process	response to UV
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0030896	cellular_component	checkpoint clamp complex
C	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
C	0033314	biological_process	mitotic DNA replication checkpoint signaling
C	0035861	cellular_component	site of double-strand break
C	0044778	biological_process	meiotic DNA integrity checkpoint signaling
C	0071479	biological_process	cellular response to ionizing radiation
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003689	molecular_function	DNA clamp loader activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005663	cellular_component	DNA replication factor C complex
D	0005694	cellular_component	chromosome
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006271	biological_process	DNA strand elongation involved in DNA replication
D	0006281	biological_process	DNA repair
D	0016887	molecular_function	ATP hydrolysis activity
D	0017116	molecular_function	single-stranded DNA helicase activity
D	0019899	molecular_function	enzyme binding
D	0031390	cellular_component	Ctf18 RFC-like complex
D	0031391	cellular_component	Elg1 RFC-like complex
D	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
E	0000731	biological_process	DNA synthesis involved in DNA repair
E	0003677	molecular_function	DNA binding
E	0003689	molecular_function	DNA clamp loader activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005663	cellular_component	DNA replication factor C complex
E	0005694	cellular_component	chromosome
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006271	biological_process	DNA strand elongation involved in DNA replication
E	0006281	biological_process	DNA repair
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0017116	molecular_function	single-stranded DNA helicase activity
E	0031390	cellular_component	Ctf18 RFC-like complex
E	0032991	cellular_component	protein-containing complex
E	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003689	molecular_function	DNA clamp loader activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005663	cellular_component	DNA replication factor C complex
F	0005694	cellular_component	chromosome
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006281	biological_process	DNA repair
F	0016887	molecular_function	ATP hydrolysis activity
F	0017116	molecular_function	single-stranded DNA helicase activity
F	0019899	molecular_function	enzyme binding
F	0031390	cellular_component	Ctf18 RFC-like complex
F	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
G	0000166	molecular_function	nucleotide binding
G	0003677	molecular_function	DNA binding
G	0003689	molecular_function	DNA clamp loader activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005663	cellular_component	DNA replication factor C complex
G	0005694	cellular_component	chromosome
G	0006260	biological_process	DNA replication
G	0006261	biological_process	DNA-templated DNA replication
G	0006281	biological_process	DNA repair
G	0016887	molecular_function	ATP hydrolysis activity
G	0017116	molecular_function	single-stranded DNA helicase activity
G	0019899	molecular_function	enzyme binding
G	0031390	cellular_component	Ctf18 RFC-like complex
G	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
K	0000076	biological_process	DNA replication checkpoint signaling
K	0000077	biological_process	DNA damage checkpoint signaling
K	0000166	molecular_function	nucleotide binding
K	0000781	cellular_component	chromosome, telomeric region
K	0003682	molecular_function	chromatin binding
K	0003684	molecular_function	damaged DNA binding
K	0003689	molecular_function	DNA clamp loader activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0006281	biological_process	DNA repair
K	0006325	biological_process	chromatin organization
K	0006974	biological_process	DNA damage response
K	0008156	biological_process	negative regulation of DNA replication
K	0021762	biological_process	substantia nigra development
K	0030896	cellular_component	checkpoint clamp complex
K	0031389	cellular_component	Rad17 RFC-like complex
K	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
K	0033314	biological_process	mitotic DNA replication checkpoint signaling
K	0035861	cellular_component	site of double-strand break
K	0042325	biological_process	regulation of phosphorylation
K	0051598	biological_process	meiotic recombination checkpoint signaling
K	0071479	biological_process	cellular response to ionizing radiation
K	0140463	molecular_function	chromatin-protein adaptor activity
K	1990166	biological_process	protein localization to site of double-strand break

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"11971963","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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