Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Z21

BAF A12T bound to the lamin A/C Ig-fold domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000793	cellular_component	condensed chromosome
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006979	biological_process	response to oxidative stress
A	0007084	biological_process	mitotic nuclear membrane reassembly
A	0009615	biological_process	response to virus
A	0010836	biological_process	negative regulation of protein ADP-ribosylation
A	0015074	biological_process	DNA integration
A	0032480	biological_process	negative regulation of type I interferon production
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0045071	biological_process	negative regulation of viral genome replication
A	0045824	biological_process	negative regulation of innate immune response
A	0051276	biological_process	chromosome organization
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
B	0000785	cellular_component	chromatin
B	0000793	cellular_component	condensed chromosome
B	0003677	molecular_function	DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006325	biological_process	chromatin organization
B	0006979	biological_process	response to oxidative stress
B	0007084	biological_process	mitotic nuclear membrane reassembly
B	0009615	biological_process	response to virus
B	0010836	biological_process	negative regulation of protein ADP-ribosylation
B	0015074	biological_process	DNA integration
B	0032480	biological_process	negative regulation of type I interferon production
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0045071	biological_process	negative regulation of viral genome replication
B	0045824	biological_process	negative regulation of innate immune response
B	0051276	biological_process	chromosome organization
B	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
C	0000785	cellular_component	chromatin
C	0000793	cellular_component	condensed chromosome
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006979	biological_process	response to oxidative stress
C	0007084	biological_process	mitotic nuclear membrane reassembly
C	0009615	biological_process	response to virus
C	0010836	biological_process	negative regulation of protein ADP-ribosylation
C	0015074	biological_process	DNA integration
C	0032480	biological_process	negative regulation of type I interferon production
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0045071	biological_process	negative regulation of viral genome replication
C	0045824	biological_process	negative regulation of innate immune response
C	0051276	biological_process	chromosome organization
C	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
D	0000785	cellular_component	chromatin
D	0000793	cellular_component	condensed chromosome
D	0003677	molecular_function	DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006325	biological_process	chromatin organization
D	0006979	biological_process	response to oxidative stress
D	0007084	biological_process	mitotic nuclear membrane reassembly
D	0009615	biological_process	response to virus
D	0010836	biological_process	negative regulation of protein ADP-ribosylation
D	0015074	biological_process	DNA integration
D	0032480	biological_process	negative regulation of type I interferon production
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0045071	biological_process	negative regulation of viral genome replication
D	0045824	biological_process	negative regulation of innate immune response
D	0051276	biological_process	chromosome organization
D	0160049	biological_process	negative regulation of cGAS/STING signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
E	SER414
F	SER414
B	THR2
B	THR3
C	THR2
C	THR3
D	THR2
D	THR3

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:24741066

Chain	Residue	Details
E	THR416
F	THR416
C	SER4
D	SER4

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:24741066

Chain	Residue	Details
F	SER423
F	SER426
E	SER423
E	SER426

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
F	SER429
F	SER533
E	SER429
E	SER533

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
E	SER431
F	SER431

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
E	LYS450
F	LYS450

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P48678

Chain	Residue	Details
E	LYS457
F	LYS457

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:24741066, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
E	SER458
F	SER458

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
E	SER463
F	SER463

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P48679

Chain	Residue	Details
F	THR496
F	THR510
E	THR496
E	THR510

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
E	THR505
F	THR505

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P48678

Chain	Residue	Details
E	SER546
F	SER546

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P48678

Chain	Residue	Details
E	THR548
F	THR548

site_id	SWS_FT_FI14
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
E	LYS417
F	LYS417

site_id	SWS_FT_FI15
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
E	LYS486
F	LYS470
F	LYS486
E	LYS470

site_id	SWS_FT_FI16
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
E	LYS420
F	LYS420

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
E	LYS450
F	LYS450

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)