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7YZF

Crystal structure of the human FoxA2 bound to the TGTTTATT site (forkhead motif ATAAACA)

Functional Information from GO Data
ChainGOidnamespacecontents
C0003700molecular_functionDNA-binding transcription factor activity
C0006355biological_processregulation of DNA-templated transcription
C0043565molecular_functionsequence-specific DNA binding
Functional Information from PROSITE/UniProt
site_idPS00657
Number of Residues14
DetailsFORK_HEAD_1 Fork head domain signature 1. KPPYSYisLitm.AI
ChainResidueDetails
CLYS159-ILE172

site_idPS00658
Number of Residues7
DetailsFORK_HEAD_2 Fork head domain signature 2. WQNSIRH
ChainResidueDetails
CTRP203-HIS209

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues93
DetailsDNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089
ChainResidueDetails
CLYS159-GLN252

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P32182
ChainResidueDetails
CTHR156

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P32182
ChainResidueDetails
CSER212

222624

PDB entries from 2024-07-17

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