7YVD
The crystal structure of the progerin C-terminal peptide and the Ig-like domain of lamin A/C
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24741066 |
| Chain | Residue | Details |
| B | SER423 | |
| B | SER426 | |
| A | SER423 | |
| A | SER426 | |
| C | SER423 | |
| C | SER426 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER533 | |
| C | SER429 | |
| C | SER533 | |
| A | SER429 | |
| A | SER533 | |
| B | SER429 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| C | SER431 | |
| A | SER431 | |
| B | SER431 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS450 | |
| B | LYS450 | |
| C | LYS450 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P48678 |
| Chain | Residue | Details |
| A | LYS457 | |
| B | LYS486 | |
| C | LYS457 | |
| C | LYS486 | |
| A | LYS486 | |
| B | LYS457 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24741066, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER458 | |
| B | SER458 | |
| C | SER458 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER463 | |
| A | SER463 | |
| C | SER463 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P48679 |
| Chain | Residue | Details |
| A | THR510 | |
| B | THR510 | |
| C | THR496 | |
| C | THR510 | |
| A | THR496 | |
| B | THR496 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | THR505 | |
| B | THR505 | |
| C | THR505 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48678 |
| Chain | Residue | Details |
| A | SER546 | |
| B | SER546 | |
| C | SER546 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P48678 |
| Chain | Residue | Details |
| A | THR548 | |
| B | THR548 | |
| C | THR548 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS450 | |
| A | LYS450 | |
| B | LYS450 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 9 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS470 | |
| A | LYS486 | |
| B | LYS470 | |
| B | LYS486 | |
| C | LYS470 | |
| C | LYS486 |
