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7YV9

Cryo-EM structure of full-length Myosin Va in the autoinhibited state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000146molecular_functionmicrofilament motor activity
A0000149molecular_functionSNARE binding
A0000166molecular_functionnucleotide binding
A0001726cellular_componentruffle
A0001750cellular_componentphotoreceptor outer segment
A0003774molecular_functioncytoskeletal motor activity
A0003779molecular_functionactin binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005777cellular_componentperoxisome
A0005783cellular_componentendoplasmic reticulum
A0005790cellular_componentsmooth endoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005882cellular_componentintermediate filament
A0005884cellular_componentactin filament
A0006582biological_processmelanin metabolic process
A0006887biological_processexocytosis
A0006892biological_processpost-Golgi vesicle-mediated transport
A0006897biological_processendocytosis
A0007015biological_processactin filament organization
A0007268biological_processchemical synaptic transmission
A0007601biological_processvisual perception
A0008021cellular_componentsynaptic vesicle
A0015031biological_processprotein transport
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016236biological_processmacroautophagy
A0016459cellular_componentmyosin complex
A0016461cellular_componentunconventional myosin complex
A0016887molecular_functionATP hydrolysis activity
A0017075molecular_functionsyntaxin-1 binding
A0017157biological_processregulation of exocytosis
A0018958biological_processphenol-containing compound metabolic process
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030048biological_processactin filament-based movement
A0030050biological_processvesicle transport along actin filament
A0030073biological_processinsulin secretion
A0030141cellular_componentsecretory granule
A0030318biological_processmelanocyte differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031267molecular_functionsmall GTPase binding
A0031982cellular_componentvesicle
A0031987biological_processlocomotion involved in locomotory behavior
A0032252biological_processsecretory granule localization
A0032400biological_processmelanosome localization
A0032402biological_processmelanosome transport
A0032433cellular_componentfilopodium tip
A0032593cellular_componentinsulin-responsive compartment
A0032869biological_processcellular response to insulin stimulus
A0033602biological_processnegative regulation of dopamine secretion
A0042417biological_processdopamine metabolic process
A0042438biological_processmelanin biosynthetic process
A0042470cellular_componentmelanosome
A0042476biological_processodontogenesis
A0042552biological_processmyelination
A0042641cellular_componentactomyosin
A0042642cellular_componentactomyosin, myosin complex part
A0042759biological_processlong-chain fatty acid biosynthetic process
A0042802molecular_functionidentical protein binding
A0043008molecular_functionATP-dependent protein binding
A0043025cellular_componentneuronal cell body
A0043473biological_processpigmentation
A0044877molecular_functionprotein-containing complex binding
A0048066biological_processdevelopmental pigmentation
A0048306molecular_functioncalcium-dependent protein binding
A0048820biological_processhair follicle maturation
A0050808biological_processsynapse organization
A0051015molecular_functionactin filament binding
A0051643biological_processendoplasmic reticulum localization
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0055037cellular_componentrecycling endosome
A0065003biological_processprotein-containing complex assembly
A0072659biological_processprotein localization to plasma membrane
A0097718molecular_functiondisordered domain specific binding
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098794cellular_componentpostsynapse
A0098871cellular_componentpostsynaptic actin cytoskeleton
A0098978cellular_componentglutamatergic synapse
A0099089biological_processestablishment of endoplasmic reticulum localization to postsynapse
A0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
A0099640biological_processaxo-dendritic protein transport
A0150103biological_processreactive gliosis
A1900078biological_processpositive regulation of cellular response to insulin stimulus
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
A1904960biological_processpositive regulation of cytochrome-c oxidase activity
A1990904cellular_componentribonucleoprotein complex
B0000086biological_processG2/M transition of mitotic cell cycle
B0000785cellular_componentchromatin
B0000922cellular_componentspindle pole
B0001975biological_processresponse to amphetamine
B0002027biological_processregulation of heart rate
B0005246molecular_functioncalcium channel regulator activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005876cellular_componentspindle microtubule
B0006897biological_processendocytosis
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008076cellular_componentvoltage-gated potassium channel complex
B0008179molecular_functionadenylate cyclase binding
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016240biological_processautophagosome membrane docking
B0019855molecular_functioncalcium channel inhibitor activity
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030017cellular_componentsarcomere
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030426cellular_componentgrowth cone
B0030672cellular_componentsynaptic vesicle membrane
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031800molecular_functiontype 3 metabotropic glutamate receptor binding
B0031966cellular_componentmitochondrial membrane
B0032465biological_processregulation of cytokinesis
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035458biological_processcellular response to interferon-beta
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0043548molecular_functionphosphatidylinositol 3-kinase binding
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050998molecular_functionnitric-oxide synthase binding
B0051412biological_processresponse to corticosterone
B0051592biological_processresponse to calcium ion
B0051649biological_processestablishment of localization in cell
B0055117biological_processregulation of cardiac muscle contraction
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0071346biological_processcellular response to type II interferon
B0072542molecular_functionprotein phosphatase activator activity
B0090150biological_processestablishment of protein localization to membrane
B0090151biological_processestablishment of protein localization to mitochondrial membrane
B0097225cellular_componentsperm midpiece
B0097720biological_processcalcineurin-mediated signaling
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098901biological_processregulation of cardiac muscle cell action potential
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0140056biological_processorganelle localization by membrane tethering
B0140238biological_processpresynaptic endocytosis
B0150034cellular_componentdistal axon
B1900242biological_processregulation of synaptic vesicle endocytosis
B1901842biological_processnegative regulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
B2000300biological_processregulation of synaptic vesicle exocytosis
C0000086biological_processG2/M transition of mitotic cell cycle
C0000785cellular_componentchromatin
C0000922cellular_componentspindle pole
C0001975biological_processresponse to amphetamine
C0002027biological_processregulation of heart rate
C0005246molecular_functioncalcium channel regulator activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005876cellular_componentspindle microtubule
C0006897biological_processendocytosis
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0008076cellular_componentvoltage-gated potassium channel complex
C0008179molecular_functionadenylate cyclase binding
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0030017cellular_componentsarcomere
C0030235molecular_functionnitric-oxide synthase regulator activity
C0030426cellular_componentgrowth cone
C0030672cellular_componentsynaptic vesicle membrane
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031800molecular_functiontype 3 metabotropic glutamate receptor binding
C0031966cellular_componentmitochondrial membrane
C0032465biological_processregulation of cytokinesis
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035458biological_processcellular response to interferon-beta
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0043548molecular_functionphosphatidylinositol 3-kinase binding
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050998molecular_functionnitric-oxide synthase binding
C0051412biological_processresponse to corticosterone
C0051592biological_processresponse to calcium ion
C0051649biological_processestablishment of localization in cell
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0072542molecular_functionprotein phosphatase activator activity
C0090150biological_processestablishment of protein localization to membrane
C0090151biological_processestablishment of protein localization to mitochondrial membrane
C0097225cellular_componentsperm midpiece
C0097720biological_processcalcineurin-mediated signaling
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098901biological_processregulation of cardiac muscle cell action potential
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0140056biological_processorganelle localization by membrane tethering
C0140238biological_processpresynaptic endocytosis
C0150034cellular_componentdistal axon
C1900242biological_processregulation of synaptic vesicle endocytosis
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C2000300biological_processregulation of synaptic vesicle exocytosis
D0000086biological_processG2/M transition of mitotic cell cycle
D0000785cellular_componentchromatin
D0000922cellular_componentspindle pole
D0001975biological_processresponse to amphetamine
D0002027biological_processregulation of heart rate
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005876cellular_componentspindle microtubule
D0006897biological_processendocytosis
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008076cellular_componentvoltage-gated potassium channel complex
D0008179molecular_functionadenylate cyclase binding
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030017cellular_componentsarcomere
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030426cellular_componentgrowth cone
D0030672cellular_componentsynaptic vesicle membrane
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031800molecular_functiontype 3 metabotropic glutamate receptor binding
D0031966cellular_componentmitochondrial membrane
D0032465biological_processregulation of cytokinesis
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035458biological_processcellular response to interferon-beta
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050998molecular_functionnitric-oxide synthase binding
D0051412biological_processresponse to corticosterone
D0051592biological_processresponse to calcium ion
D0051649biological_processestablishment of localization in cell
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0072542molecular_functionprotein phosphatase activator activity
D0090150biological_processestablishment of protein localization to membrane
D0090151biological_processestablishment of protein localization to mitochondrial membrane
D0097225cellular_componentsperm midpiece
D0097720biological_processcalcineurin-mediated signaling
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098901biological_processregulation of cardiac muscle cell action potential
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0140056biological_processorganelle localization by membrane tethering
D0140238biological_processpresynaptic endocytosis
D0150034cellular_componentdistal axon
D1900242biological_processregulation of synaptic vesicle endocytosis
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D2000300biological_processregulation of synaptic vesicle exocytosis
E0000086biological_processG2/M transition of mitotic cell cycle
E0000785cellular_componentchromatin
E0000922cellular_componentspindle pole
E0001975biological_processresponse to amphetamine
E0002027biological_processregulation of heart rate
E0005246molecular_functioncalcium channel regulator activity
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005876cellular_componentspindle microtubule
E0006897biological_processendocytosis
E0007259biological_processcell surface receptor signaling pathway via JAK-STAT
E0008076cellular_componentvoltage-gated potassium channel complex
E0008179molecular_functionadenylate cyclase binding
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0019904molecular_functionprotein domain specific binding
E0030017cellular_componentsarcomere
E0030235molecular_functionnitric-oxide synthase regulator activity
E0030426cellular_componentgrowth cone
E0030672cellular_componentsynaptic vesicle membrane
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031800molecular_functiontype 3 metabotropic glutamate receptor binding
E0031966cellular_componentmitochondrial membrane
E0032465biological_processregulation of cytokinesis
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035458biological_processcellular response to interferon-beta
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0043548molecular_functionphosphatidylinositol 3-kinase binding
E0044305cellular_componentcalyx of Held
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050998molecular_functionnitric-oxide synthase binding
E0051412biological_processresponse to corticosterone
E0051592biological_processresponse to calcium ion
E0051649biological_processestablishment of localization in cell
E0055117biological_processregulation of cardiac muscle contraction
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0072542molecular_functionprotein phosphatase activator activity
E0090150biological_processestablishment of protein localization to membrane
E0090151biological_processestablishment of protein localization to mitochondrial membrane
E0097225cellular_componentsperm midpiece
E0097720biological_processcalcineurin-mediated signaling
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098901biological_processregulation of cardiac muscle cell action potential
E0099523cellular_componentpresynaptic cytosol
E0099524cellular_componentpostsynaptic cytosol
E0140056biological_processorganelle localization by membrane tethering
E0140238biological_processpresynaptic endocytosis
E0150034cellular_componentdistal axon
E1900242biological_processregulation of synaptic vesicle endocytosis
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
E2000300biological_processregulation of synaptic vesicle exocytosis
F0000086biological_processG2/M transition of mitotic cell cycle
F0000785cellular_componentchromatin
F0000922cellular_componentspindle pole
F0001975biological_processresponse to amphetamine
F0002027biological_processregulation of heart rate
F0005246molecular_functioncalcium channel regulator activity
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005876cellular_componentspindle microtubule
F0006897biological_processendocytosis
F0007259biological_processcell surface receptor signaling pathway via JAK-STAT
F0008076cellular_componentvoltage-gated potassium channel complex
F0008179molecular_functionadenylate cyclase binding
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0019904molecular_functionprotein domain specific binding
F0030017cellular_componentsarcomere
F0030235molecular_functionnitric-oxide synthase regulator activity
F0030426cellular_componentgrowth cone
F0030672cellular_componentsynaptic vesicle membrane
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031800molecular_functiontype 3 metabotropic glutamate receptor binding
F0031966cellular_componentmitochondrial membrane
F0032465biological_processregulation of cytokinesis
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035458biological_processcellular response to interferon-beta
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0043548molecular_functionphosphatidylinositol 3-kinase binding
F0044305cellular_componentcalyx of Held
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050998molecular_functionnitric-oxide synthase binding
F0051412biological_processresponse to corticosterone
F0051592biological_processresponse to calcium ion
F0051649biological_processestablishment of localization in cell
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0072542molecular_functionprotein phosphatase activator activity
F0090150biological_processestablishment of protein localization to membrane
F0090151biological_processestablishment of protein localization to mitochondrial membrane
F0097225cellular_componentsperm midpiece
F0097720biological_processcalcineurin-mediated signaling
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098901biological_processregulation of cardiac muscle cell action potential
F0099523cellular_componentpresynaptic cytosol
F0099524cellular_componentpostsynaptic cytosol
F0140056biological_processorganelle localization by membrane tethering
F0140238biological_processpresynaptic endocytosis
F0150034cellular_componentdistal axon
F1900242biological_processregulation of synaptic vesicle endocytosis
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
F2000300biological_processregulation of synaptic vesicle exocytosis
G0000086biological_processG2/M transition of mitotic cell cycle
G0000785cellular_componentchromatin
G0000922cellular_componentspindle pole
G0001975biological_processresponse to amphetamine
G0002027biological_processregulation of heart rate
G0005246molecular_functioncalcium channel regulator activity
G0005509molecular_functioncalcium ion binding
G0005513biological_processdetection of calcium ion
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005819cellular_componentspindle
G0005829cellular_componentcytosol
G0005876cellular_componentspindle microtubule
G0006897biological_processendocytosis
G0007259biological_processcell surface receptor signaling pathway via JAK-STAT
G0008076cellular_componentvoltage-gated potassium channel complex
G0008179molecular_functionadenylate cyclase binding
G0010856molecular_functionadenylate cyclase activator activity
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016240biological_processautophagosome membrane docking
G0019855molecular_functioncalcium channel inhibitor activity
G0019901molecular_functionprotein kinase binding
G0019904molecular_functionprotein domain specific binding
G0030017cellular_componentsarcomere
G0030235molecular_functionnitric-oxide synthase regulator activity
G0030426cellular_componentgrowth cone
G0030672cellular_componentsynaptic vesicle membrane
G0031432molecular_functiontitin binding
G0031514cellular_componentmotile cilium
G0031800molecular_functiontype 3 metabotropic glutamate receptor binding
G0031966cellular_componentmitochondrial membrane
G0032465biological_processregulation of cytokinesis
G0032991cellular_componentprotein-containing complex
G0034704cellular_componentcalcium channel complex
G0035458biological_processcellular response to interferon-beta
G0043209cellular_componentmyelin sheath
G0043539molecular_functionprotein serine/threonine kinase activator activity
G0043548molecular_functionphosphatidylinositol 3-kinase binding
G0044305cellular_componentcalyx of Held
G0044325molecular_functiontransmembrane transporter binding
G0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
G0046872molecular_functionmetal ion binding
G0048306molecular_functioncalcium-dependent protein binding
G0050998molecular_functionnitric-oxide synthase binding
G0051412biological_processresponse to corticosterone
G0051592biological_processresponse to calcium ion
G0051649biological_processestablishment of localization in cell
G0055117biological_processregulation of cardiac muscle contraction
G0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
G0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
G0071346biological_processcellular response to type II interferon
G0072542molecular_functionprotein phosphatase activator activity
G0090150biological_processestablishment of protein localization to membrane
G0090151biological_processestablishment of protein localization to mitochondrial membrane
G0097225cellular_componentsperm midpiece
G0097720biological_processcalcineurin-mediated signaling
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098901biological_processregulation of cardiac muscle cell action potential
G0099523cellular_componentpresynaptic cytosol
G0099524cellular_componentpostsynaptic cytosol
G0140056biological_processorganelle localization by membrane tethering
G0140238biological_processpresynaptic endocytosis
G0150034cellular_componentdistal axon
G1900242biological_processregulation of synaptic vesicle endocytosis
G1901842biological_processnegative regulation of high voltage-gated calcium channel activity
G1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
G1902494cellular_componentcatalytic complex
G1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
G2000300biological_processregulation of synaptic vesicle exocytosis
H0000146molecular_functionmicrofilament motor activity
H0000149molecular_functionSNARE binding
H0000166molecular_functionnucleotide binding
H0001726cellular_componentruffle
H0001750cellular_componentphotoreceptor outer segment
H0003774molecular_functioncytoskeletal motor activity
H0003779molecular_functionactin binding
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005516molecular_functioncalmodulin binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005764cellular_componentlysosome
H0005769cellular_componentearly endosome
H0005770cellular_componentlate endosome
H0005777cellular_componentperoxisome
H0005783cellular_componentendoplasmic reticulum
H0005790cellular_componentsmooth endoplasmic reticulum
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0005882cellular_componentintermediate filament
H0005884cellular_componentactin filament
H0006582biological_processmelanin metabolic process
H0006887biological_processexocytosis
H0006892biological_processpost-Golgi vesicle-mediated transport
H0006897biological_processendocytosis
H0007015biological_processactin filament organization
H0007268biological_processchemical synaptic transmission
H0007601biological_processvisual perception
H0008021cellular_componentsynaptic vesicle
H0015031biological_processprotein transport
H0015629cellular_componentactin cytoskeleton
H0016020cellular_componentmembrane
H0016192biological_processvesicle-mediated transport
H0016236biological_processmacroautophagy
H0016459cellular_componentmyosin complex
H0016461cellular_componentunconventional myosin complex
H0016887molecular_functionATP hydrolysis activity
H0017075molecular_functionsyntaxin-1 binding
H0017157biological_processregulation of exocytosis
H0018958biological_processphenol-containing compound metabolic process
H0019899molecular_functionenzyme binding
H0019901molecular_functionprotein kinase binding
H0030048biological_processactin filament-based movement
H0030050biological_processvesicle transport along actin filament
H0030073biological_processinsulin secretion
H0030141cellular_componentsecretory granule
H0030318biological_processmelanocyte differentiation
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0031267molecular_functionsmall GTPase binding
H0031982cellular_componentvesicle
H0031987biological_processlocomotion involved in locomotory behavior
H0032252biological_processsecretory granule localization
H0032400biological_processmelanosome localization
H0032402biological_processmelanosome transport
H0032433cellular_componentfilopodium tip
H0032593cellular_componentinsulin-responsive compartment
H0032869biological_processcellular response to insulin stimulus
H0033602biological_processnegative regulation of dopamine secretion
H0042417biological_processdopamine metabolic process
H0042438biological_processmelanin biosynthetic process
H0042470cellular_componentmelanosome
H0042476biological_processodontogenesis
H0042552biological_processmyelination
H0042641cellular_componentactomyosin
H0042642cellular_componentactomyosin, myosin complex part
H0042759biological_processlong-chain fatty acid biosynthetic process
H0042802molecular_functionidentical protein binding
H0043008molecular_functionATP-dependent protein binding
H0043025cellular_componentneuronal cell body
H0043473biological_processpigmentation
H0044877molecular_functionprotein-containing complex binding
H0048066biological_processdevelopmental pigmentation
H0048306molecular_functioncalcium-dependent protein binding
H0048820biological_processhair follicle maturation
H0050808biological_processsynapse organization
H0051015molecular_functionactin filament binding
H0051643biological_processendoplasmic reticulum localization
H0051967biological_processnegative regulation of synaptic transmission, glutamatergic
H0055037cellular_componentrecycling endosome
H0065003biological_processprotein-containing complex assembly
H0072659biological_processprotein localization to plasma membrane
H0097718molecular_functiondisordered domain specific binding
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098794cellular_componentpostsynapse
H0098871cellular_componentpostsynaptic actin cytoskeleton
H0098978cellular_componentglutamatergic synapse
H0099089biological_processestablishment of endoplasmic reticulum localization to postsynapse
H0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
H0099640biological_processaxo-dendritic protein transport
H0150103biological_processreactive gliosis
H1900078biological_processpositive regulation of cellular response to insulin stimulus
H1903078biological_processpositive regulation of protein localization to plasma membrane
H1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
H1904960biological_processpositive regulation of cytochrome-c oxidase activity
H1990904cellular_componentribonucleoprotein complex
I0000086biological_processG2/M transition of mitotic cell cycle
I0000785cellular_componentchromatin
I0000922cellular_componentspindle pole
I0001975biological_processresponse to amphetamine
I0002027biological_processregulation of heart rate
I0005246molecular_functioncalcium channel regulator activity
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005876cellular_componentspindle microtubule
I0006897biological_processendocytosis
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008076cellular_componentvoltage-gated potassium channel complex
I0008179molecular_functionadenylate cyclase binding
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0019904molecular_functionprotein domain specific binding
I0030017cellular_componentsarcomere
I0030235molecular_functionnitric-oxide synthase regulator activity
I0030426cellular_componentgrowth cone
I0030672cellular_componentsynaptic vesicle membrane
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031800molecular_functiontype 3 metabotropic glutamate receptor binding
I0031966cellular_componentmitochondrial membrane
I0032465biological_processregulation of cytokinesis
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035458biological_processcellular response to interferon-beta
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0043548molecular_functionphosphatidylinositol 3-kinase binding
I0044305cellular_componentcalyx of Held
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050998molecular_functionnitric-oxide synthase binding
I0051412biological_processresponse to corticosterone
I0051592biological_processresponse to calcium ion
I0051649biological_processestablishment of localization in cell
I0055117biological_processregulation of cardiac muscle contraction
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0072542molecular_functionprotein phosphatase activator activity
I0090150biological_processestablishment of protein localization to membrane
I0090151biological_processestablishment of protein localization to mitochondrial membrane
I0097225cellular_componentsperm midpiece
I0097720biological_processcalcineurin-mediated signaling
I0098685cellular_componentSchaffer collateral - CA1 synapse
I0098901biological_processregulation of cardiac muscle cell action potential
I0099523cellular_componentpresynaptic cytosol
I0099524cellular_componentpostsynaptic cytosol
I0140056biological_processorganelle localization by membrane tethering
I0140238biological_processpresynaptic endocytosis
I0150034cellular_componentdistal axon
I1900242biological_processregulation of synaptic vesicle endocytosis
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
I2000300biological_processregulation of synaptic vesicle exocytosis
J0000086biological_processG2/M transition of mitotic cell cycle
J0000785cellular_componentchromatin
J0000922cellular_componentspindle pole
J0001975biological_processresponse to amphetamine
J0002027biological_processregulation of heart rate
J0005246molecular_functioncalcium channel regulator activity
J0005509molecular_functioncalcium ion binding
J0005513biological_processdetection of calcium ion
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005876cellular_componentspindle microtubule
J0006897biological_processendocytosis
J0007259biological_processcell surface receptor signaling pathway via JAK-STAT
J0008076cellular_componentvoltage-gated potassium channel complex
J0008179molecular_functionadenylate cyclase binding
J0010856molecular_functionadenylate cyclase activator activity
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016240biological_processautophagosome membrane docking
J0019855molecular_functioncalcium channel inhibitor activity
J0019901molecular_functionprotein kinase binding
J0019904molecular_functionprotein domain specific binding
J0030017cellular_componentsarcomere
J0030235molecular_functionnitric-oxide synthase regulator activity
J0030426cellular_componentgrowth cone
J0030672cellular_componentsynaptic vesicle membrane
J0031432molecular_functiontitin binding
J0031514cellular_componentmotile cilium
J0031800molecular_functiontype 3 metabotropic glutamate receptor binding
J0031966cellular_componentmitochondrial membrane
J0032465biological_processregulation of cytokinesis
J0032991cellular_componentprotein-containing complex
J0034704cellular_componentcalcium channel complex
J0035458biological_processcellular response to interferon-beta
J0043209cellular_componentmyelin sheath
J0043539molecular_functionprotein serine/threonine kinase activator activity
J0043548molecular_functionphosphatidylinositol 3-kinase binding
J0044305cellular_componentcalyx of Held
J0044325molecular_functiontransmembrane transporter binding
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0048306molecular_functioncalcium-dependent protein binding
J0050998molecular_functionnitric-oxide synthase binding
J0051412biological_processresponse to corticosterone
J0051592biological_processresponse to calcium ion
J0051649biological_processestablishment of localization in cell
J0055117biological_processregulation of cardiac muscle contraction
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0071346biological_processcellular response to type II interferon
J0072542molecular_functionprotein phosphatase activator activity
J0090150biological_processestablishment of protein localization to membrane
J0090151biological_processestablishment of protein localization to mitochondrial membrane
J0097225cellular_componentsperm midpiece
J0097720biological_processcalcineurin-mediated signaling
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098901biological_processregulation of cardiac muscle cell action potential
J0099523cellular_componentpresynaptic cytosol
J0099524cellular_componentpostsynaptic cytosol
J0140056biological_processorganelle localization by membrane tethering
J0140238biological_processpresynaptic endocytosis
J0150034cellular_componentdistal axon
J1900242biological_processregulation of synaptic vesicle endocytosis
J1901842biological_processnegative regulation of high voltage-gated calcium channel activity
J1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
J1902494cellular_componentcatalytic complex
J1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J2000300biological_processregulation of synaptic vesicle exocytosis
K0000086biological_processG2/M transition of mitotic cell cycle
K0000785cellular_componentchromatin
K0000922cellular_componentspindle pole
K0001975biological_processresponse to amphetamine
K0002027biological_processregulation of heart rate
K0005246molecular_functioncalcium channel regulator activity
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005876cellular_componentspindle microtubule
K0006897biological_processendocytosis
K0007259biological_processcell surface receptor signaling pathway via JAK-STAT
K0008076cellular_componentvoltage-gated potassium channel complex
K0008179molecular_functionadenylate cyclase binding
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0019904molecular_functionprotein domain specific binding
K0030017cellular_componentsarcomere
K0030235molecular_functionnitric-oxide synthase regulator activity
K0030426cellular_componentgrowth cone
K0030672cellular_componentsynaptic vesicle membrane
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031800molecular_functiontype 3 metabotropic glutamate receptor binding
K0031966cellular_componentmitochondrial membrane
K0032465biological_processregulation of cytokinesis
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035458biological_processcellular response to interferon-beta
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0043548molecular_functionphosphatidylinositol 3-kinase binding
K0044305cellular_componentcalyx of Held
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050998molecular_functionnitric-oxide synthase binding
K0051412biological_processresponse to corticosterone
K0051592biological_processresponse to calcium ion
K0051649biological_processestablishment of localization in cell
K0055117biological_processregulation of cardiac muscle contraction
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0072542molecular_functionprotein phosphatase activator activity
K0090150biological_processestablishment of protein localization to membrane
K0090151biological_processestablishment of protein localization to mitochondrial membrane
K0097225cellular_componentsperm midpiece
K0097720biological_processcalcineurin-mediated signaling
K0098685cellular_componentSchaffer collateral - CA1 synapse
K0098901biological_processregulation of cardiac muscle cell action potential
K0099523cellular_componentpresynaptic cytosol
K0099524cellular_componentpostsynaptic cytosol
K0140056biological_processorganelle localization by membrane tethering
K0140238biological_processpresynaptic endocytosis
K0150034cellular_componentdistal axon
K1900242biological_processregulation of synaptic vesicle endocytosis
K1901842biological_processnegative regulation of high voltage-gated calcium channel activity
K1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
K1902494cellular_componentcatalytic complex
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
K2000300biological_processregulation of synaptic vesicle exocytosis
L0000086biological_processG2/M transition of mitotic cell cycle
L0000785cellular_componentchromatin
L0000922cellular_componentspindle pole
L0001975biological_processresponse to amphetamine
L0002027biological_processregulation of heart rate
L0005246molecular_functioncalcium channel regulator activity
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005876cellular_componentspindle microtubule
L0006897biological_processendocytosis
L0007259biological_processcell surface receptor signaling pathway via JAK-STAT
L0008076cellular_componentvoltage-gated potassium channel complex
L0008179molecular_functionadenylate cyclase binding
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0019904molecular_functionprotein domain specific binding
L0030017cellular_componentsarcomere
L0030235molecular_functionnitric-oxide synthase regulator activity
L0030426cellular_componentgrowth cone
L0030672cellular_componentsynaptic vesicle membrane
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031800molecular_functiontype 3 metabotropic glutamate receptor binding
L0031966cellular_componentmitochondrial membrane
L0032465biological_processregulation of cytokinesis
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035458biological_processcellular response to interferon-beta
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0043548molecular_functionphosphatidylinositol 3-kinase binding
L0044305cellular_componentcalyx of Held
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050998molecular_functionnitric-oxide synthase binding
L0051412biological_processresponse to corticosterone
L0051592biological_processresponse to calcium ion
L0051649biological_processestablishment of localization in cell
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L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
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L0090150biological_processestablishment of protein localization to membrane
L0090151biological_processestablishment of protein localization to mitochondrial membrane
L0097225cellular_componentsperm midpiece
L0097720biological_processcalcineurin-mediated signaling
L0098685cellular_componentSchaffer collateral - CA1 synapse
L0098901biological_processregulation of cardiac muscle cell action potential
L0099523cellular_componentpresynaptic cytosol
L0099524cellular_componentpostsynaptic cytosol
L0140056biological_processorganelle localization by membrane tethering
L0140238biological_processpresynaptic endocytosis
L0150034cellular_componentdistal axon
L1900242biological_processregulation of synaptic vesicle endocytosis
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
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L2000300biological_processregulation of synaptic vesicle exocytosis
M0000086biological_processG2/M transition of mitotic cell cycle
M0000785cellular_componentchromatin
M0000922cellular_componentspindle pole
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M0002027biological_processregulation of heart rate
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M0005513biological_processdetection of calcium ion
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M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0005813cellular_componentcentrosome
M0005819cellular_componentspindle
M0005829cellular_componentcytosol
M0005876cellular_componentspindle microtubule
M0006897biological_processendocytosis
M0007259biological_processcell surface receptor signaling pathway via JAK-STAT
M0008076cellular_componentvoltage-gated potassium channel complex
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M0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
M0016240biological_processautophagosome membrane docking
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M0030426cellular_componentgrowth cone
M0030672cellular_componentsynaptic vesicle membrane
M0031432molecular_functiontitin binding
M0031514cellular_componentmotile cilium
M0031800molecular_functiontype 3 metabotropic glutamate receptor binding
M0031966cellular_componentmitochondrial membrane
M0032465biological_processregulation of cytokinesis
M0032991cellular_componentprotein-containing complex
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M0035458biological_processcellular response to interferon-beta
M0043209cellular_componentmyelin sheath
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M0097225cellular_componentsperm midpiece
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M0098901biological_processregulation of cardiac muscle cell action potential
M0099523cellular_componentpresynaptic cytosol
M0099524cellular_componentpostsynaptic cytosol
M0140056biological_processorganelle localization by membrane tethering
M0140238biological_processpresynaptic endocytosis
M0150034cellular_componentdistal axon
M1900242biological_processregulation of synaptic vesicle endocytosis
M1901842biological_processnegative regulation of high voltage-gated calcium channel activity
M1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
M1902494cellular_componentcatalytic complex
M1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
M2000300biological_processregulation of synaptic vesicle exocytosis
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N0001975biological_processresponse to amphetamine
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N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005813cellular_componentcentrosome
N0005819cellular_componentspindle
N0005829cellular_componentcytosol
N0005876cellular_componentspindle microtubule
N0006897biological_processendocytosis
N0007259biological_processcell surface receptor signaling pathway via JAK-STAT
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N0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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N0030672cellular_componentsynaptic vesicle membrane
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N0031514cellular_componentmotile cilium
N0031800molecular_functiontype 3 metabotropic glutamate receptor binding
N0031966cellular_componentmitochondrial membrane
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N0044305cellular_componentcalyx of Held
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N0050998molecular_functionnitric-oxide synthase binding
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N0051592biological_processresponse to calcium ion
N0051649biological_processestablishment of localization in cell
N0055117biological_processregulation of cardiac muscle contraction
N0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
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N0090151biological_processestablishment of protein localization to mitochondrial membrane
N0097225cellular_componentsperm midpiece
N0097720biological_processcalcineurin-mediated signaling
N0098685cellular_componentSchaffer collateral - CA1 synapse
N0098901biological_processregulation of cardiac muscle cell action potential
N0099523cellular_componentpresynaptic cytosol
N0099524cellular_componentpostsynaptic cytosol
N0140056biological_processorganelle localization by membrane tethering
N0140238biological_processpresynaptic endocytosis
N0150034cellular_componentdistal axon
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N1901842biological_processnegative regulation of high voltage-gated calcium channel activity
N1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
N1902494cellular_componentcatalytic complex
N1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
N2000300biological_processregulation of synaptic vesicle exocytosis
X0000146molecular_functionmicrofilament motor activity
X0000149molecular_functionSNARE binding
X0000166molecular_functionnucleotide binding
X0001726cellular_componentruffle
X0001750cellular_componentphotoreceptor outer segment
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X0005764cellular_componentlysosome
X0005769cellular_componentearly endosome
X0005770cellular_componentlate endosome
X0005777cellular_componentperoxisome
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X0005790cellular_componentsmooth endoplasmic reticulum
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X0005882cellular_componentintermediate filament
X0005884cellular_componentactin filament
X0006582biological_processmelanin metabolic process
X0006887biological_processexocytosis
X0006892biological_processpost-Golgi vesicle-mediated transport
X0006897biological_processendocytosis
X0007015biological_processactin filament organization
X0007268biological_processchemical synaptic transmission
X0007601biological_processvisual perception
X0008021cellular_componentsynaptic vesicle
X0015031biological_processprotein transport
X0015629cellular_componentactin cytoskeleton
X0016020cellular_componentmembrane
X0016192biological_processvesicle-mediated transport
X0016236biological_processmacroautophagy
X0016459cellular_componentmyosin complex
X0016461cellular_componentunconventional myosin complex
X0016887molecular_functionATP hydrolysis activity
X0017075molecular_functionsyntaxin-1 binding
X0017157biological_processregulation of exocytosis
X0018958biological_processphenol-containing compound metabolic process
X0019899molecular_functionenzyme binding
X0019901molecular_functionprotein kinase binding
X0030048biological_processactin filament-based movement
X0030050biological_processvesicle transport along actin filament
X0030073biological_processinsulin secretion
X0030141cellular_componentsecretory granule
X0030318biological_processmelanocyte differentiation
X0030424cellular_componentaxon
X0030425cellular_componentdendrite
X0031267molecular_functionsmall GTPase binding
X0031982cellular_componentvesicle
X0031987biological_processlocomotion involved in locomotory behavior
X0032252biological_processsecretory granule localization
X0032400biological_processmelanosome localization
X0032402biological_processmelanosome transport
X0032433cellular_componentfilopodium tip
X0032593cellular_componentinsulin-responsive compartment
X0032869biological_processcellular response to insulin stimulus
X0033602biological_processnegative regulation of dopamine secretion
X0042417biological_processdopamine metabolic process
X0042438biological_processmelanin biosynthetic process
X0042470cellular_componentmelanosome
X0042476biological_processodontogenesis
X0042552biological_processmyelination
X0042641cellular_componentactomyosin
X0042642cellular_componentactomyosin, myosin complex part
X0042759biological_processlong-chain fatty acid biosynthetic process
X0042802molecular_functionidentical protein binding
X0043008molecular_functionATP-dependent protein binding
X0043025cellular_componentneuronal cell body
X0043473biological_processpigmentation
X0044877molecular_functionprotein-containing complex binding
X0048066biological_processdevelopmental pigmentation
X0048306molecular_functioncalcium-dependent protein binding
X0048820biological_processhair follicle maturation
X0050808biological_processsynapse organization
X0051015molecular_functionactin filament binding
X0051643biological_processendoplasmic reticulum localization
X0051967biological_processnegative regulation of synaptic transmission, glutamatergic
X0055037cellular_componentrecycling endosome
X0065003biological_processprotein-containing complex assembly
X0072659biological_processprotein localization to plasma membrane
X0097718molecular_functiondisordered domain specific binding
X0098685cellular_componentSchaffer collateral - CA1 synapse
X0098794cellular_componentpostsynapse
X0098871cellular_componentpostsynaptic actin cytoskeleton
X0098978cellular_componentglutamatergic synapse
X0099089biological_processestablishment of endoplasmic reticulum localization to postsynapse
X0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
X0099640biological_processaxo-dendritic protein transport
X0150103biological_processreactive gliosis
X1900078biological_processpositive regulation of cellular response to insulin stimulus
X1903078biological_processpositive regulation of protein localization to plasma membrane
X1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
X1904960biological_processpositive regulation of cytochrome-c oxidase activity
X1990904cellular_componentribonucleoprotein complex
Y0000146molecular_functionmicrofilament motor activity
Y0000149molecular_functionSNARE binding
Y0000166molecular_functionnucleotide binding
Y0001726cellular_componentruffle
Y0001750cellular_componentphotoreceptor outer segment
Y0003774molecular_functioncytoskeletal motor activity
Y0003779molecular_functionactin binding
Y0005509molecular_functioncalcium ion binding
Y0005515molecular_functionprotein binding
Y0005516molecular_functioncalmodulin binding
Y0005524molecular_functionATP binding
Y0005737cellular_componentcytoplasm
Y0005764cellular_componentlysosome
Y0005769cellular_componentearly endosome
Y0005770cellular_componentlate endosome
Y0005777cellular_componentperoxisome
Y0005783cellular_componentendoplasmic reticulum
Y0005790cellular_componentsmooth endoplasmic reticulum
Y0005794cellular_componentGolgi apparatus
Y0005829cellular_componentcytosol
Y0005882cellular_componentintermediate filament
Y0005884cellular_componentactin filament
Y0006582biological_processmelanin metabolic process
Y0006887biological_processexocytosis
Y0006892biological_processpost-Golgi vesicle-mediated transport
Y0006897biological_processendocytosis
Y0007015biological_processactin filament organization
Y0007268biological_processchemical synaptic transmission
Y0007601biological_processvisual perception
Y0008021cellular_componentsynaptic vesicle
Y0015031biological_processprotein transport
Y0015629cellular_componentactin cytoskeleton
Y0016020cellular_componentmembrane
Y0016192biological_processvesicle-mediated transport
Y0016236biological_processmacroautophagy
Y0016459cellular_componentmyosin complex
Y0016461cellular_componentunconventional myosin complex
Y0016887molecular_functionATP hydrolysis activity
Y0017075molecular_functionsyntaxin-1 binding
Y0017157biological_processregulation of exocytosis
Y0018958biological_processphenol-containing compound metabolic process
Y0019899molecular_functionenzyme binding
Y0019901molecular_functionprotein kinase binding
Y0030048biological_processactin filament-based movement
Y0030050biological_processvesicle transport along actin filament
Y0030073biological_processinsulin secretion
Y0030141cellular_componentsecretory granule
Y0030318biological_processmelanocyte differentiation
Y0030424cellular_componentaxon
Y0030425cellular_componentdendrite
Y0031267molecular_functionsmall GTPase binding
Y0031982cellular_componentvesicle
Y0031987biological_processlocomotion involved in locomotory behavior
Y0032252biological_processsecretory granule localization
Y0032400biological_processmelanosome localization
Y0032402biological_processmelanosome transport
Y0032433cellular_componentfilopodium tip
Y0032593cellular_componentinsulin-responsive compartment
Y0032869biological_processcellular response to insulin stimulus
Y0033602biological_processnegative regulation of dopamine secretion
Y0042417biological_processdopamine metabolic process
Y0042438biological_processmelanin biosynthetic process
Y0042470cellular_componentmelanosome
Y0042476biological_processodontogenesis
Y0042552biological_processmyelination
Y0042641cellular_componentactomyosin
Y0042642cellular_componentactomyosin, myosin complex part
Y0042759biological_processlong-chain fatty acid biosynthetic process
Y0042802molecular_functionidentical protein binding
Y0043008molecular_functionATP-dependent protein binding
Y0043025cellular_componentneuronal cell body
Y0043473biological_processpigmentation
Y0044877molecular_functionprotein-containing complex binding
Y0048066biological_processdevelopmental pigmentation
Y0048306molecular_functioncalcium-dependent protein binding
Y0048820biological_processhair follicle maturation
Y0050808biological_processsynapse organization
Y0051015molecular_functionactin filament binding
Y0051643biological_processendoplasmic reticulum localization
Y0051967biological_processnegative regulation of synaptic transmission, glutamatergic
Y0055037cellular_componentrecycling endosome
Y0065003biological_processprotein-containing complex assembly
Y0072659biological_processprotein localization to plasma membrane
Y0097718molecular_functiondisordered domain specific binding
Y0098685cellular_componentSchaffer collateral - CA1 synapse
Y0098794cellular_componentpostsynapse
Y0098871cellular_componentpostsynaptic actin cytoskeleton
Y0098978cellular_componentglutamatergic synapse
Y0099089biological_processestablishment of endoplasmic reticulum localization to postsynapse
Y0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
Y0099640biological_processaxo-dendritic protein transport
Y0150103biological_processreactive gliosis
Y1900078biological_processpositive regulation of cellular response to insulin stimulus
Y1903078biological_processpositive regulation of protein localization to plasma membrane
Y1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
Y1904960biological_processpositive regulation of cytochrome-c oxidase activity
Y1990904cellular_componentribonucleoprotein complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues104
DetailsDomain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues44
DetailsRegion: {"description":"Actin-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues44
DetailsDomain: {"description":"IQ 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues48
DetailsDomain: {"description":"IQ 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues44
DetailsDomain: {"description":"IQ 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues48
DetailsDomain: {"description":"IQ 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues44
DetailsDomain: {"description":"IQ 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues56
DetailsDomain: {"description":"IQ 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9QYF3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues420
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues420
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues420
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues384
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues864
DetailsRegion: {"description":"Necessary and sufficient for interaction with PCP4","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues240
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"4HEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZLK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues12
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18034455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues12
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues12
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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