7YDP
Cryo-EM structure of CD97/miniGs complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003924 | molecular_function | GTPase activity |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0019001 | molecular_function | guanyl nucleotide binding |
A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
B | 0001750 | cellular_component | photoreceptor outer segment |
B | 0003924 | molecular_function | GTPase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005765 | cellular_component | lysosomal membrane |
B | 0005829 | cellular_component | cytosol |
B | 0005834 | cellular_component | heterotrimeric G-protein complex |
B | 0005886 | cellular_component | plasma membrane |
B | 0007165 | biological_process | signal transduction |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
B | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
B | 0007265 | biological_process | Ras protein signal transduction |
B | 0008283 | biological_process | cell population proliferation |
B | 0016020 | cellular_component | membrane |
B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0045202 | cellular_component | synapse |
B | 0050909 | biological_process | sensory perception of taste |
B | 0051020 | molecular_function | GTPase binding |
B | 0060041 | biological_process | retina development in camera-type eye |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
B | 0071870 | biological_process | cellular response to catecholamine stimulus |
B | 0097381 | cellular_component | photoreceptor disc membrane |
B | 1903561 | cellular_component | extracellular vesicle |
C | 0005515 | molecular_function | protein binding |
C | 0005834 | cellular_component | heterotrimeric G-protein complex |
C | 0005886 | cellular_component | plasma membrane |
C | 0007165 | biological_process | signal transduction |
C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
C | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
C | 0016020 | cellular_component | membrane |
C | 0031681 | molecular_function | G-protein beta-subunit binding |
C | 0048144 | biological_process | fibroblast proliferation |
C | 0070062 | cellular_component | extracellular exosome |
C | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
C | 0071870 | biological_process | cellular response to catecholamine stimulus |
R | 0004888 | molecular_function | transmembrane signaling receptor activity |
R | 0004930 | molecular_function | G protein-coupled receptor activity |
R | 0007166 | biological_process | cell surface receptor signaling pathway |
R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
R | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
site_id | PS00650 |
Number of Residues | 16 |
Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGAFLyLLHCLlNkkV |
Chain | Residue | Details |
R | GLN778-VAL793 |
site_id | PS00678 |
Number of Residues | 15 |
Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
Chain | Residue | Details |
B | LEU70-SER84 | |
B | ILE157-ILE171 | |
B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q |
Chain | Residue | Details |
A | SER174 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q |
Chain | Residue | Details |
A | LEU198 | |
R | ARG643-ARG653 | |
R | THR713-THR739 | |
R | ASN790-ILE835 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 |
Chain | Residue | Details |
A | THR204 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
Chain | Residue | Details |
A | ARG201 | |
R | SER675-GLY691 | |
R | ASP761-VAL766 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805 |
Chain | Residue | Details |
A | GLY9 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824 |
Chain | Residue | Details |
A | CYS10 |
site_id | SWS_FT_FI7 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04896 |
Chain | Residue | Details |
A | GLY47 | |
A | SER54 | |
A | ASP223 | |
A | ASN292 | |
A | SER366 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | SER352 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
Chain | Residue | Details |
A | LYS300 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | SITE: Cleavage; by autolysis => ECO:0000255|PROSITE-ProRule:PRU00098 |
Chain | Residue | Details |
R | MET530 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
R | SER815 | |
R | SER818 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
R | THR816 | |
R | THR825 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
R | SER831 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
R | SER833 |