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7Y5O

Crystal structure of human CAF-1 core complex in spacegroup P21

Functional Information from GO Data
ChainGOidnamespacecontents
B0006335biological_processDNA replication-dependent chromatin assembly
C0000118cellular_componenthistone deacetylase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005829cellular_componentcytosol
C0006260biological_processDNA replication
C0006325biological_processchromatin organization
C0006334biological_processnucleosome assembly
C0006335biological_processDNA replication-dependent chromatin assembly
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0007420biological_processbrain development
C0008094molecular_functionATP-dependent activity, acting on DNA
C0008285biological_processnegative regulation of cell population proliferation
C0016581cellular_componentNuRD complex
C0016589cellular_componentNURF complex
C0030336biological_processnegative regulation of cell migration
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0031492molecular_functionnucleosomal DNA binding
C0032991cellular_componentprotein-containing complex
C0033186cellular_componentCAF-1 complex
C0035098cellular_componentESC/E(Z) complex
C0042393molecular_functionhistone binding
C0042659biological_processregulation of cell fate specification
C0042826molecular_functionhistone deacetylase binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0070822cellular_componentSin3-type complex
C1902455biological_processnegative regulation of stem cell population maintenance
C1902459biological_processpositive regulation of stem cell population maintenance
C1904949cellular_componentATPase complex
C2000736biological_processregulation of stem cell differentiation
E0006335biological_processDNA replication-dependent chromatin assembly
F0000118cellular_componenthistone deacetylase complex
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0005829cellular_componentcytosol
F0006260biological_processDNA replication
F0006325biological_processchromatin organization
F0006334biological_processnucleosome assembly
F0006335biological_processDNA replication-dependent chromatin assembly
F0006338biological_processchromatin remodeling
F0006355biological_processregulation of DNA-templated transcription
F0007420biological_processbrain development
F0008094molecular_functionATP-dependent activity, acting on DNA
F0008285biological_processnegative regulation of cell population proliferation
F0016581cellular_componentNuRD complex
F0016589cellular_componentNURF complex
F0030336biological_processnegative regulation of cell migration
F0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
F0031492molecular_functionnucleosomal DNA binding
F0032991cellular_componentprotein-containing complex
F0033186cellular_componentCAF-1 complex
F0035098cellular_componentESC/E(Z) complex
F0042393molecular_functionhistone binding
F0042659biological_processregulation of cell fate specification
F0042826molecular_functionhistone deacetylase binding
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0070822cellular_componentSin3-type complex
F1902455biological_processnegative regulation of stem cell population maintenance
F1902459biological_processpositive regulation of stem cell population maintenance
F1904949cellular_componentATPase complex
F2000736biological_processregulation of stem cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
CLEU193-ILE207
CLEU289-LEU303
CLEU333-LEU347
BMET144-VAL158

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2
FALA2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS4
FLYS4

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER110
FSER110

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60972
ChainResidueDetails
CLYS160
FLYS160

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER355
FSER355

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
CLYS4
FLYS4

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS160
FLYS160

227111

PDB entries from 2024-11-06

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