Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Y1K

Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0001508	biological_process	action potential
A	0001568	biological_process	blood vessel development
A	0001666	biological_process	response to hypoxia
A	0001669	cellular_component	acrosomal vesicle
A	0003007	biological_process	heart morphogenesis
A	0003018	biological_process	vascular process in circulatory system
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005886	cellular_component	plasma membrane
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006813	biological_process	potassium ion transport
A	0006932	biological_process	substrate-dependent cell migration, cell contraction
A	0006950	biological_process	response to stress
A	0007005	biological_process	mitochondrion organization
A	0007507	biological_process	heart development
A	0007519	biological_process	skeletal muscle tissue development
A	0008015	biological_process	blood circulation
A	0008217	biological_process	regulation of blood pressure
A	0008281	molecular_function	sulfonylurea receptor activity
A	0008282	cellular_component	inward rectifying potassium channel
A	0009410	biological_process	response to xenobiotic stimulus
A	0010467	biological_process	gene expression
A	0014823	biological_process	response to activity
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0019395	biological_process	fatty acid oxidation
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0019905	molecular_function	syntaxin binding
A	0022857	molecular_function	transmembrane transporter activity
A	0030017	cellular_component	sarcomere
A	0030315	cellular_component	T-tubule
A	0031004	cellular_component	potassium ion-transporting ATPase complex
A	0032991	cellular_component	protein-containing complex
A	0033198	biological_process	response to ATP
A	0035864	biological_process	response to potassium ion
A	0035865	biological_process	cellular response to potassium ion
A	0036293	biological_process	response to decreased oxygen levels
A	0042311	biological_process	vasodilation
A	0042383	cellular_component	sarcolemma
A	0042391	biological_process	regulation of membrane potential
A	0042542	biological_process	response to hydrogen peroxide
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0043627	biological_process	response to estrogen
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045333	biological_process	cellular respiration
A	0045776	biological_process	negative regulation of blood pressure
A	0046034	biological_process	ATP metabolic process
A	0048144	biological_process	fibroblast proliferation
A	0051607	biological_process	defense response to virus
A	0055085	biological_process	transmembrane transport
A	0060976	biological_process	coronary vasculature development
A	0061337	biological_process	cardiac conduction
A	0062197	biological_process	cellular response to chemical stress
A	0070482	biological_process	response to oxygen levels
A	0071277	biological_process	cellular response to calcium ion
A	0071318	biological_process	cellular response to ATP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071805	biological_process	potassium ion transmembrane transport
A	0072359	biological_process	circulatory system development
A	0072592	biological_process	oxygen metabolic process
A	0086003	biological_process	cardiac muscle cell contraction
A	0097746	biological_process	blood vessel diameter maintenance
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098662	biological_process	inorganic cation transmembrane transport
A	0099104	molecular_function	potassium channel activator activity
A	0140359	molecular_function	ABC-type transporter activity
A	1901363	molecular_function	heterocyclic compound binding
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1901652	biological_process	response to peptide
A	1903409	biological_process	reactive oxygen species biosynthetic process
A	1904880	biological_process	response to hydrogen sulfide
A	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRICVARAL

Chain	Residue	Details
A	LEU808-LEU822
A	PHE1445-PHE1459

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	176
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	124
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	234
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)