Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004996 | molecular_function | thyroid-stimulating hormone receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007187 | biological_process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0007267 | biological_process | cell-cell signaling |
| R | 0008284 | biological_process | positive regulation of cell population proliferation |
| R | 0008528 | molecular_function | G protein-coupled peptide receptor activity |
| R | 0009755 | biological_process | hormone-mediated signaling pathway |
| R | 0009986 | cellular_component | cell surface |
| R | 0016020 | cellular_component | membrane |
| R | 0016323 | cellular_component | basolateral plasma membrane |
| R | 0016500 | molecular_function | protein-hormone receptor activity |
| R | 0038023 | molecular_function | signaling receptor activity |
| R | 0038194 | biological_process | thyroid-stimulating hormone signaling pathway |
| R | 0043235 | cellular_component | receptor complex |
| R | 0044877 | molecular_function | protein-containing complex binding |
| R | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| R | 1904588 | biological_process | cellular response to glycoprotein |
| R | 1905229 | biological_process | cellular response to thyrotropin-releasing hormone |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. LSVyTLTVITLERWYaI |
| Chain | Residue | Details |
| R | LEU507-ILE523 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 441 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY21-MET463 | |
| R | THR524-GLY544 | |
| R | PRO611-ILE630 | |
| R | LYS700-ARG710 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY464-GLY491 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 130 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| R | PRO492-PHE500 | |
| R | ILE568-LEU587 | |
| R | LEU653-PRO675 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| R | THR501-ILE523 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY545-SER567 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | THR588-ASN610 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | PHE631-PRO652 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | PHE676-CYS699 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL711-LEU732 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000305|PubMed:11847099 |
| Chain | Residue | Details |
| R | VAL435 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11502179, ECO:0000269|PubMed:17542669 |
| Chain | Residue | Details |
| R | ASN77 | |
| R | ASN113 | |
| R | ASN198 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17542669 |
| Chain | Residue | Details |
| R | ASN99 | |
| R | ASN177 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11502179 |
| Chain | Residue | Details |
| R | ASN352 |
