7XUM
Structure of ATP7B C983S/C985S/D1027A mutant with Cu+ in presence of ATOX1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005375 | molecular_function | copper ion transmembrane transporter activity |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005768 | cellular_component | endosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006825 | biological_process | copper ion transport |
| A | 0006878 | biological_process | intracellular copper ion homeostasis |
| A | 0006882 | biological_process | intracellular zinc ion homeostasis |
| A | 0007595 | biological_process | lactation |
| A | 0015677 | biological_process | copper ion import |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019829 | molecular_function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0032588 | cellular_component | trans-Golgi network membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0043682 | molecular_function | P-type divalent copper transporter activity |
| A | 0046688 | biological_process | response to copper ion |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051208 | biological_process | sequestering of calcium ion |
| A | 0051604 | biological_process | protein maturation |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0060003 | biological_process | copper ion export |
| A | 0075523 | biological_process | viral translational frameshifting |
| A | 0140581 | molecular_function | P-type monovalent copper transporter activity |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01047 |
| Number of Residues | 30 |
| Details | HMA_1 Heavy-metal-associated domain. IlGMtCqSCvksIEdrIsnlkgiismk.VsL |
| Chain | Residue | Details |
| A | ILE64-LEU93 | |
| A | VAL149-LEU178 | |
| A | ILE263-LEU292 | |
| A | ILE365-LEU394 | |
| A | ILE494-LEU523 | |
| A | ILE570-LEU599 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 159 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 139 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 66 |
| Details | Domain: {"description":"HMA 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00280","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00280","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18558714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20032459","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64535","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
