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7XT2

Crystal structure of TRIM72

Functional Information from GO Data
ChainGOidnamespacecontents
A0001778biological_processplasma membrane repair
A0001786molecular_functionphosphatidylserine binding
A0003012biological_processmuscle system process
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006887biological_processexocytosis
A0007517biological_processmuscle organ development
A0008270molecular_functionzinc ion binding
A0010832biological_processnegative regulation of myotube differentiation
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0031624molecular_functionubiquitin conjugating enzyme binding
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
A0045087biological_processinnate immune response
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0061630molecular_functionubiquitin protein ligase activity
B0001778biological_processplasma membrane repair
B0001786molecular_functionphosphatidylserine binding
B0003012biological_processmuscle system process
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006887biological_processexocytosis
B0007517biological_processmuscle organ development
B0008270molecular_functionzinc ion binding
B0010832biological_processnegative regulation of myotube differentiation
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031624molecular_functionubiquitin conjugating enzyme binding
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
B0045087biological_processinnate immune response
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0061630molecular_functionubiquitin protein ligase activity
Functional Information from PROSITE/UniProt
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHsFCraCL
ChainResidueDetails
BCYS29-LEU38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues86
DetailsZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
ChainResidueDetails
BCYS14-GLN57
ACYS14-GLN57

site_idSWS_FT_FI2
Number of Residues82
DetailsZN_FING: B box-type => ECO:0000255|PROSITE-ProRule:PRU00024
ChainResidueDetails
BVAL81-ALA122
AVAL81-ALA122

site_idSWS_FT_FI3
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q1XH17
ChainResidueDetails
BCYS14
ACYS17
ACYS29
AHIS31
ACYS34
ACYS37
ACYS53
ACYS56
BCYS17
BCYS29
BHIS31
BCYS34
BCYS37
BCYS53
BCYS56
ACYS14

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00024, ECO:0007744|PDB:7XT2
ChainResidueDetails
BCYS86
BHIS89
BCYS108
BHIS114
ACYS86
AHIS89
ACYS108
AHIS114

site_idSWS_FT_FI5
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:7XT2
ChainResidueDetails
BCYS97
BASP100
BCYS105
BHIS117
ACYS97
AASP100
ACYS105
AHIS117

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:24487118
ChainResidueDetails
BCYS144
ACYS144

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:A0JPQ4
ChainResidueDetails
BSER255
ASER255

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PDB entries from 2025-06-18

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