7XO8
SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three human ACE2 Bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0019031 | cellular_component | viral envelope |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0055036 | cellular_component | virion membrane |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0016020 | cellular_component | membrane |
| B | 0019031 | cellular_component | viral envelope |
| B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| B | 0055036 | cellular_component | virion membrane |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| C | 0016020 | cellular_component | membrane |
| C | 0019031 | cellular_component | viral envelope |
| C | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| C | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| C | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| C | 0055036 | cellular_component | virion membrane |
| C | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| D | 0016020 | cellular_component | membrane |
| E | 0006508 | biological_process | proteolysis |
| E | 0008237 | molecular_function | metallopeptidase activity |
| E | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| E | 0016020 | cellular_component | membrane |
| F | 0006508 | biological_process | proteolysis |
| F | 0008237 | molecular_function | metallopeptidase activity |
| F | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| D | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2166 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| D | GLN18-SER740 | |
| F | GLN18-SER740 | |
| E | GLN18-SER740 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU01354 |
| Chain | Residue | Details |
| D | ILE741-ILE761 | |
| F | ILE741-ILE761 | |
| E | ILE741-ILE761 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 129 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| D | PHE762-PHE805 | |
| F | PHE762-PHE805 | |
| E | PHE762-PHE805 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
| Chain | Residue | Details |
| D | GLU375 | |
| F | GLU375 | |
| E | GLU375 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | HIS505 | |
| F | HIS505 | |
| E | HIS505 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
| Chain | Residue | Details |
| B | GLY1246 | |
| C | THR1238 | |
| C | SER1239 | |
| C | CYS1243 | |
| C | LEU1244 | |
| C | GLY1246 | |
| D | ARG169 | |
| D | TRP477 | |
| D | LYS481 | |
| F | ARG169 | |
| F | TRP477 | |
| F | LYS481 | |
| E | ARG169 | |
| E | TRP477 | |
| E | LYS481 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| B | ASP1257 | |
| C | CYS1250 | |
| C | GLY1251 | |
| C | CYS1253 | |
| C | PHE1256 | |
| C | ASP1257 | |
| D | ARG273 | |
| D | HIS345 | |
| D | TYR515 | |
| F | ARG273 | |
| F | HIS345 | |
| F | TYR515 | |
| E | ARG273 | |
| E | HIS345 | |
| E | TYR515 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| D | HIS374 | |
| D | HIS378 | |
| D | GLU402 | |
| F | HIS374 | |
| F | HIS378 | |
| F | GLU402 | |
| E | HIS374 | |
| E | HIS378 | |
| E | GLU402 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
| Chain | Residue | Details |
| D | TYR781 | |
| F | TYR781 | |
| E | TYR781 | |
| A | GLN804 | |
| A | THR1077 | |
| B | TRP64 | |
| B | ASN125 | |
| B | ILE720 | |
| B | GLN804 | |
| B | THR1077 | |
| C | TRP64 | |
| C | ASN125 | |
| C | ILE720 | |
| C | GLN804 | |
| C | THR1077 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
| Chain | Residue | Details |
| D | SER783 | |
| F | SER783 | |
| E | SER783 | |
| B | LYS77 | |
| B | TRP152 | |
| B | LEU1197 | |
| C | LYS77 | |
| C | TRP152 | |
| C | LEU1197 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | ASN53 | |
| D | ASN322 | |
| F | ASN53 | |
| F | ASN322 | |
| E | ASN53 | |
| E | ASN322 | |
| A | HIS1101 | |
| B | PHE168 | |
| B | ILE285 | |
| B | ASN334 | |
| B | ARG346 | |
| B | GLU619 | |
| B | TYR660 | |
| B | HIS1101 | |
| C | PHE168 | |
| C | ILE285 | |
| C | ASN334 | |
| C | ARG346 | |
| C | GLU619 | |
| C | TYR660 | |
| C | HIS1101 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| D | ASN90 | |
| F | ASN90 | |
| E | ASN90 | |
| B | ILE712 | |
| C | ARG237 | |
| C | ILE712 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| D | ASN103 | |
| D | ASN432 | |
| F | ASN103 | |
| F | ASN432 | |
| E | ASN103 | |
| E | ASN432 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| D | ASN546 | |
| F | ASN546 | |
| E | ASN546 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN690 | |
| F | ASN690 | |
| E | ASN690 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523 |
| Chain | Residue | Details |
| A | HIS681 | |
| F | LYS788 | |
| B | HIS681 | |
| C | HIS681 | |
| D | LYS788 | |
| E | LYS788 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | VAL1137 | |
| B | VAL1137 | |
| C | VAL1137 |
