7XNK

human KCNQ1-CaM in complex with ML277

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0001696	biological_process	gastric acid secretion
A	0001698	biological_process	gastrin-induced gastric acid secretion
A	0002027	biological_process	regulation of heart rate
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005251	molecular_function	delayed rectifier potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0007507	biological_process	heart development
A	0007605	biological_process	sensory perception of sound
A	0007622	biological_process	rhythmic behavior
A	0008016	biological_process	regulation of heart contraction
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008157	molecular_function	protein phosphatase 1 binding
A	0008217	biological_process	regulation of blood pressure
A	0010460	biological_process	positive regulation of heart rate
A	0015271	molecular_function	outward rectifier potassium channel activity
A	0015705	biological_process	iodide transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0022600	biological_process	digestive system process
A	0030133	cellular_component	transport vesicle
A	0030218	biological_process	erythrocyte differentiation
A	0030644	biological_process	intracellular chloride ion homeostasis
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0032868	biological_process	response to insulin
A	0034236	molecular_function	protein kinase A catalytic subunit binding
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034702	cellular_component	monoatomic ion channel complex
A	0034705	cellular_component	potassium channel complex
A	0035176	biological_process	social behavior
A	0035934	biological_process	corticosterone secretion
A	0042472	biological_process	inner ear morphogenesis
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0044325	molecular_function	transmembrane transporter binding
A	0045121	cellular_component	membrane raft
A	0045177	cellular_component	apical part of cell
A	0048839	biological_process	inner ear development
A	0050892	biological_process	intestinal absorption
A	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
A	0055064	biological_process	chloride ion homeostasis
A	0055075	biological_process	potassium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0060048	biological_process	cardiac muscle contraction
A	0060117	biological_process	auditory receptor cell development
A	0060306	biological_process	regulation of membrane repolarization
A	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
A	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
A	0060452	biological_process	positive regulation of cardiac muscle contraction
A	0060453	biological_process	regulation of gastric acid secretion
A	0061337	biological_process	cardiac conduction
A	0062094	biological_process	stomach development
A	0070293	biological_process	renal absorption
A	0070294	biological_process	renal sodium ion absorption
A	0071320	biological_process	cellular response to cAMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071805	biological_process	potassium ion transmembrane transport
A	0071872	biological_process	cellular response to epinephrine stimulus
A	0071875	biological_process	adrenergic receptor signaling pathway
A	0086003	biological_process	cardiac muscle cell contraction
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A	0086009	biological_process	membrane repolarization
A	0086011	biological_process	membrane repolarization during action potential
A	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
A	0086014	biological_process	atrial cardiac muscle cell action potential
A	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0090102	biological_process	cochlea development
A	0097110	molecular_function	scaffold protein binding
A	0097546	cellular_component	ciliary base
A	0097623	biological_process	potassium ion export across plasma membrane
A	0098576	cellular_component	lumenal side of membrane
A	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
A	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
A	1901381	biological_process	positive regulation of potassium ion transmembrane transport
A	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A	1905515	biological_process	non-motile cilium assembly
A	1990573	biological_process	potassium ion import across plasma membrane
A	1990794	cellular_component	basolateral part of cell
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000922	cellular_component	spindle pole
B	0002027	biological_process	regulation of heart rate
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005856	cellular_component	cytoskeleton
B	0005876	cellular_component	spindle microtubule
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0008179	molecular_function	adenylate cyclase binding
B	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
B	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030017	cellular_component	sarcomere
B	0031432	molecular_function	titin binding
B	0031954	biological_process	positive regulation of protein autophosphorylation
B	0031982	cellular_component	vesicle
B	0032465	biological_process	regulation of cytokinesis
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0044305	cellular_component	calyx of Held
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
B	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
B	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
B	0072542	molecular_function	protein phosphatase activator activity
B	0097225	cellular_component	sperm midpiece
B	0097720	biological_process	calcineurin-mediated signaling
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0099523	cellular_component	presynaptic cytosol
B	0140238	biological_process	presynaptic endocytosis
B	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	1902494	cellular_component	catalytic complex
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	0001508	biological_process	action potential
C	0001696	biological_process	gastric acid secretion
C	0001698	biological_process	gastrin-induced gastric acid secretion
C	0002027	biological_process	regulation of heart rate
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005251	molecular_function	delayed rectifier potassium channel activity
C	0005267	molecular_function	potassium channel activity
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005768	cellular_component	endosome
C	0005769	cellular_component	early endosome
C	0005770	cellular_component	late endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0007507	biological_process	heart development
C	0007605	biological_process	sensory perception of sound
C	0007622	biological_process	rhythmic behavior
C	0008016	biological_process	regulation of heart contraction
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008157	molecular_function	protein phosphatase 1 binding
C	0008217	biological_process	regulation of blood pressure
C	0010460	biological_process	positive regulation of heart rate
C	0015271	molecular_function	outward rectifier potassium channel activity
C	0015705	biological_process	iodide transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0016324	cellular_component	apical plasma membrane
C	0022600	biological_process	digestive system process
C	0030133	cellular_component	transport vesicle
C	0030218	biological_process	erythrocyte differentiation
C	0030644	biological_process	intracellular chloride ion homeostasis
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0032868	biological_process	response to insulin
C	0034236	molecular_function	protein kinase A catalytic subunit binding
C	0034237	molecular_function	protein kinase A regulatory subunit binding
C	0034702	cellular_component	monoatomic ion channel complex
C	0034705	cellular_component	potassium channel complex
C	0035176	biological_process	social behavior
C	0035934	biological_process	corticosterone secretion
C	0042472	biological_process	inner ear morphogenesis
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0044325	molecular_function	transmembrane transporter binding
C	0045121	cellular_component	membrane raft
C	0045177	cellular_component	apical part of cell
C	0048839	biological_process	inner ear development
C	0050892	biological_process	intestinal absorption
C	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
C	0055064	biological_process	chloride ion homeostasis
C	0055075	biological_process	potassium ion homeostasis
C	0055085	biological_process	transmembrane transport
C	0060048	biological_process	cardiac muscle contraction
C	0060117	biological_process	auditory receptor cell development
C	0060306	biological_process	regulation of membrane repolarization
C	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
C	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
C	0060452	biological_process	positive regulation of cardiac muscle contraction
C	0060453	biological_process	regulation of gastric acid secretion
C	0061337	biological_process	cardiac conduction
C	0062094	biological_process	stomach development
C	0070293	biological_process	renal absorption
C	0070294	biological_process	renal sodium ion absorption
C	0071320	biological_process	cellular response to cAMP
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071805	biological_process	potassium ion transmembrane transport
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0071875	biological_process	adrenergic receptor signaling pathway
C	0086003	biological_process	cardiac muscle cell contraction
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
C	0086009	biological_process	membrane repolarization
C	0086011	biological_process	membrane repolarization during action potential
C	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
C	0086014	biological_process	atrial cardiac muscle cell action potential
C	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
C	0086091	biological_process	regulation of heart rate by cardiac conduction
C	0090102	biological_process	cochlea development
C	0097110	molecular_function	scaffold protein binding
C	0097546	cellular_component	ciliary base
C	0097623	biological_process	potassium ion export across plasma membrane
C	0098576	cellular_component	lumenal side of membrane
C	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
C	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
C	1901381	biological_process	positive regulation of potassium ion transmembrane transport
C	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C	1905515	biological_process	non-motile cilium assembly
C	1990573	biological_process	potassium ion import across plasma membrane
C	1990794	cellular_component	basolateral part of cell
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0002027	biological_process	regulation of heart rate
D	0005509	molecular_function	calcium ion binding
D	0005513	biological_process	detection of calcium ion
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005856	cellular_component	cytoskeleton
D	0005876	cellular_component	spindle microtubule
D	0005886	cellular_component	plasma membrane
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0008179	molecular_function	adenylate cyclase binding
D	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
D	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
D	0010856	molecular_function	adenylate cyclase activator activity
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0019901	molecular_function	protein kinase binding
D	0021762	biological_process	substantia nigra development
D	0030017	cellular_component	sarcomere
D	0031432	molecular_function	titin binding
D	0031954	biological_process	positive regulation of protein autophosphorylation
D	0031982	cellular_component	vesicle
D	0032465	biological_process	regulation of cytokinesis
D	0032991	cellular_component	protein-containing complex
D	0034704	cellular_component	calcium channel complex
D	0043209	cellular_component	myelin sheath
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0044305	cellular_component	calyx of Held
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0051592	biological_process	response to calcium ion
D	0055117	biological_process	regulation of cardiac muscle contraction
D	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
D	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
D	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
D	0072542	molecular_function	protein phosphatase activator activity
D	0097225	cellular_component	sperm midpiece
D	0097720	biological_process	calcineurin-mediated signaling
D	0098901	biological_process	regulation of cardiac muscle cell action potential
D	0099523	cellular_component	presynaptic cytosol
D	0140238	biological_process	presynaptic endocytosis
D	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
D	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
D	1902494	cellular_component	catalytic complex
D	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	0001508	biological_process	action potential
E	0001696	biological_process	gastric acid secretion
E	0001698	biological_process	gastrin-induced gastric acid secretion
E	0002027	biological_process	regulation of heart rate
E	0005216	molecular_function	monoatomic ion channel activity
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005251	molecular_function	delayed rectifier potassium channel activity
E	0005267	molecular_function	potassium channel activity
E	0005515	molecular_function	protein binding
E	0005516	molecular_function	calmodulin binding
E	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005768	cellular_component	endosome
E	0005769	cellular_component	early endosome
E	0005770	cellular_component	late endosome
E	0005783	cellular_component	endoplasmic reticulum
E	0005886	cellular_component	plasma membrane
E	0006006	biological_process	glucose metabolic process
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006814	biological_process	sodium ion transport
E	0007507	biological_process	heart development
E	0007605	biological_process	sensory perception of sound
E	0007622	biological_process	rhythmic behavior
E	0008016	biological_process	regulation of heart contraction
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008157	molecular_function	protein phosphatase 1 binding
E	0008217	biological_process	regulation of blood pressure
E	0010460	biological_process	positive regulation of heart rate
E	0015271	molecular_function	outward rectifier potassium channel activity
E	0015705	biological_process	iodide transport
E	0016020	cellular_component	membrane
E	0016323	cellular_component	basolateral plasma membrane
E	0016324	cellular_component	apical plasma membrane
E	0022600	biological_process	digestive system process
E	0030133	cellular_component	transport vesicle
E	0030218	biological_process	erythrocyte differentiation
E	0030644	biological_process	intracellular chloride ion homeostasis
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0032868	biological_process	response to insulin
E	0034236	molecular_function	protein kinase A catalytic subunit binding
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034702	cellular_component	monoatomic ion channel complex
E	0034705	cellular_component	potassium channel complex
E	0035176	biological_process	social behavior
E	0035934	biological_process	corticosterone secretion
E	0042472	biological_process	inner ear morphogenesis
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0044325	molecular_function	transmembrane transporter binding
E	0045121	cellular_component	membrane raft
E	0045177	cellular_component	apical part of cell
E	0048839	biological_process	inner ear development
E	0050892	biological_process	intestinal absorption
E	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
E	0055064	biological_process	chloride ion homeostasis
E	0055075	biological_process	potassium ion homeostasis
E	0055085	biological_process	transmembrane transport
E	0060048	biological_process	cardiac muscle contraction
E	0060117	biological_process	auditory receptor cell development
E	0060306	biological_process	regulation of membrane repolarization
E	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
E	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
E	0060452	biological_process	positive regulation of cardiac muscle contraction
E	0060453	biological_process	regulation of gastric acid secretion
E	0061337	biological_process	cardiac conduction
E	0062094	biological_process	stomach development
E	0070293	biological_process	renal absorption
E	0070294	biological_process	renal sodium ion absorption
E	0071320	biological_process	cellular response to cAMP
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0071805	biological_process	potassium ion transmembrane transport
E	0071872	biological_process	cellular response to epinephrine stimulus
E	0071875	biological_process	adrenergic receptor signaling pathway
E	0086003	biological_process	cardiac muscle cell contraction
E	0086005	biological_process	ventricular cardiac muscle cell action potential
E	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
E	0086009	biological_process	membrane repolarization
E	0086011	biological_process	membrane repolarization during action potential
E	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
E	0086014	biological_process	atrial cardiac muscle cell action potential
E	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
E	0086091	biological_process	regulation of heart rate by cardiac conduction
E	0090102	biological_process	cochlea development
E	0097110	molecular_function	scaffold protein binding
E	0097546	cellular_component	ciliary base
E	0097623	biological_process	potassium ion export across plasma membrane
E	0098576	cellular_component	lumenal side of membrane
E	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
E	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
E	1901381	biological_process	positive regulation of potassium ion transmembrane transport
E	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
E	1905515	biological_process	non-motile cilium assembly
E	1990573	biological_process	potassium ion import across plasma membrane
E	1990794	cellular_component	basolateral part of cell
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0002027	biological_process	regulation of heart rate
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005856	cellular_component	cytoskeleton
F	0005876	cellular_component	spindle microtubule
F	0005886	cellular_component	plasma membrane
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0008179	molecular_function	adenylate cyclase binding
F	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
F	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0019901	molecular_function	protein kinase binding
F	0021762	biological_process	substantia nigra development
F	0030017	cellular_component	sarcomere
F	0031432	molecular_function	titin binding
F	0031954	biological_process	positive regulation of protein autophosphorylation
F	0031982	cellular_component	vesicle
F	0032465	biological_process	regulation of cytokinesis
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0044305	cellular_component	calyx of Held
F	0044325	molecular_function	transmembrane transporter binding
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
F	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
F	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
F	0072542	molecular_function	protein phosphatase activator activity
F	0097225	cellular_component	sperm midpiece
F	0097720	biological_process	calcineurin-mediated signaling
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0099523	cellular_component	presynaptic cytosol
F	0140238	biological_process	presynaptic endocytosis
F	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
F	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
F	1902494	cellular_component	catalytic complex
F	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
G	0001508	biological_process	action potential
G	0001696	biological_process	gastric acid secretion
G	0001698	biological_process	gastrin-induced gastric acid secretion
G	0002027	biological_process	regulation of heart rate
G	0005216	molecular_function	monoatomic ion channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005251	molecular_function	delayed rectifier potassium channel activity
G	0005267	molecular_function	potassium channel activity
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005768	cellular_component	endosome
G	0005769	cellular_component	early endosome
G	0005770	cellular_component	late endosome
G	0005783	cellular_component	endoplasmic reticulum
G	0005886	cellular_component	plasma membrane
G	0006006	biological_process	glucose metabolic process
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0006814	biological_process	sodium ion transport
G	0007507	biological_process	heart development
G	0007605	biological_process	sensory perception of sound
G	0007622	biological_process	rhythmic behavior
G	0008016	biological_process	regulation of heart contraction
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008157	molecular_function	protein phosphatase 1 binding
G	0008217	biological_process	regulation of blood pressure
G	0010460	biological_process	positive regulation of heart rate
G	0015271	molecular_function	outward rectifier potassium channel activity
G	0015705	biological_process	iodide transport
G	0016020	cellular_component	membrane
G	0016323	cellular_component	basolateral plasma membrane
G	0016324	cellular_component	apical plasma membrane
G	0022600	biological_process	digestive system process
G	0030133	cellular_component	transport vesicle
G	0030218	biological_process	erythrocyte differentiation
G	0030644	biological_process	intracellular chloride ion homeostasis
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0032868	biological_process	response to insulin
G	0034236	molecular_function	protein kinase A catalytic subunit binding
G	0034237	molecular_function	protein kinase A regulatory subunit binding
G	0034702	cellular_component	monoatomic ion channel complex
G	0034705	cellular_component	potassium channel complex
G	0035176	biological_process	social behavior
G	0035934	biological_process	corticosterone secretion
G	0042472	biological_process	inner ear morphogenesis
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0044325	molecular_function	transmembrane transporter binding
G	0045121	cellular_component	membrane raft
G	0045177	cellular_component	apical part of cell
G	0048839	biological_process	inner ear development
G	0050892	biological_process	intestinal absorption
G	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
G	0055064	biological_process	chloride ion homeostasis
G	0055075	biological_process	potassium ion homeostasis
G	0055085	biological_process	transmembrane transport
G	0060048	biological_process	cardiac muscle contraction
G	0060117	biological_process	auditory receptor cell development
G	0060306	biological_process	regulation of membrane repolarization
G	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
G	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
G	0060452	biological_process	positive regulation of cardiac muscle contraction
G	0060453	biological_process	regulation of gastric acid secretion
G	0061337	biological_process	cardiac conduction
G	0062094	biological_process	stomach development
G	0070293	biological_process	renal absorption
G	0070294	biological_process	renal sodium ion absorption
G	0071320	biological_process	cellular response to cAMP
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	0071805	biological_process	potassium ion transmembrane transport
G	0071872	biological_process	cellular response to epinephrine stimulus
G	0071875	biological_process	adrenergic receptor signaling pathway
G	0086003	biological_process	cardiac muscle cell contraction
G	0086005	biological_process	ventricular cardiac muscle cell action potential
G	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
G	0086009	biological_process	membrane repolarization
G	0086011	biological_process	membrane repolarization during action potential
G	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
G	0086014	biological_process	atrial cardiac muscle cell action potential
G	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
G	0086091	biological_process	regulation of heart rate by cardiac conduction
G	0090102	biological_process	cochlea development
G	0097110	molecular_function	scaffold protein binding
G	0097546	cellular_component	ciliary base
G	0097623	biological_process	potassium ion export across plasma membrane
G	0098576	cellular_component	lumenal side of membrane
G	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
G	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
G	1901381	biological_process	positive regulation of potassium ion transmembrane transport
G	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G	1905515	biological_process	non-motile cilium assembly
G	1990573	biological_process	potassium ion import across plasma membrane
G	1990794	cellular_component	basolateral part of cell
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0002027	biological_process	regulation of heart rate
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0008179	molecular_function	adenylate cyclase binding
H	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
H	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0031432	molecular_function	titin binding
H	0031954	biological_process	positive regulation of protein autophosphorylation
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
H	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
H	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0140238	biological_process	presynaptic endocytosis
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
B	ASP21-LEU33
B	ASP57-PHE69
B	ASP94-LEU106
B	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585

Chain	Residue	Details
B	ASP21
B	GLU68
B	ASP94
B	ASP96
B	ASN98
B	TYR100
B	GLU105
B	ASP130
B	ASP132
B	ASP134
B	GLN136
B	ASP23
B	GLU141
D	ASP21
D	ASP23
D	ASP25
D	THR27
D	GLU32
D	ASP57
D	ASP59
D	ASN61
D	THR63
B	ASP25
D	GLU68
D	ASP94
D	ASP96
D	ASN98
D	TYR100
D	GLU105
D	ASP130
D	ASP132
D	ASP134
D	GLN136
B	THR27
D	GLU141
F	ASP21
F	ASP23
F	ASP25
F	THR27
F	GLU32
F	ASP57
F	ASP59
F	ASN61
F	THR63
B	GLU32
F	GLU68
F	ASP94
F	ASP96
F	ASN98
F	TYR100
F	GLU105
F	ASP130
F	ASP132
F	ASP134
F	GLN136
B	ASP57
F	GLU141
H	ASP21
H	ASP23
H	ASP25
H	THR27
H	GLU32
H	ASP57
H	ASP59
H	ASN61
H	THR63
B	ASP59
H	GLU68
H	ASP94
H	ASP96
H	ASN98
H	TYR100
H	GLU105
H	ASP130
H	ASP132
H	ASP134
H	GLN136
B	ASN61
H	GLU141
B	THR63

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
B	ALA2
D	ALA2
F	ALA2
H	ALA2

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS22
E	LYS218-SER225
E	ALA283-TYR299
E	GLN321-THR327
G	SER143-GLN147
G	LYS218-SER225
G	ALA283-TYR299
G	GLN321-THR327
D	LYS22
F	LYS22
H	LYS22
C	SER143-GLN147
C	LYS218-SER225
C	ALA283-TYR299
C	GLN321-THR327
E	SER143-GLN147

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP31

Chain	Residue	Details
B	THR45
D	THR45
F	THR45
H	THR45

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER82
D	SER82
F	SER82
H	SER82

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS95
D	LYS95
F	LYS95
H	LYS95

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
B	TYR100
D	TYR100
F	TYR100
H	TYR100

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER102
D	SER102
F	SER102
H	SER102

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	THR111
D	THR111
F	THR111
H	THR111

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
B	LYS116
D	LYS116
F	LYS116
H	LYS116

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
B	TYR139
D	TYR139
F	TYR139
H	TYR139
E	SER407
E	SER409
G	SER407
G	SER409

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
B	LYS22
C	ASN289
D	LYS22
G	ASN289
F	LYS22
H	LYS22

---