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7XNI

human KCNQ1-CaM in apo state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0001696biological_processgastric acid secretion
A0001698biological_processgastrin-induced gastric acid secretion
A0002027biological_processregulation of heart rate
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006006biological_processglucose metabolic process
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0007507biological_processheart development
A0007605biological_processsensory perception of sound
A0007622biological_processrhythmic behavior
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0008157molecular_functionprotein phosphatase 1 binding
A0008217biological_processregulation of blood pressure
A0010460biological_processpositive regulation of heart rate
A0015271molecular_functionoutward rectifier potassium channel activity
A0015705biological_processiodide transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0022600biological_processdigestive system process
A0030133cellular_componenttransport vesicle
A0030218biological_processerythrocyte differentiation
A0030644biological_processintracellular chloride ion homeostasis
A0030659cellular_componentcytoplasmic vesicle membrane
A0032868biological_processresponse to insulin
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034702cellular_componentmonoatomic ion channel complex
A0034705cellular_componentpotassium channel complex
A0035176biological_processsocial behavior
A0035934biological_processcorticosterone secretion
A0042472biological_processinner ear morphogenesis
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0044325molecular_functiontransmembrane transporter binding
A0045121cellular_componentmembrane raft
A0045177cellular_componentapical part of cell
A0048839biological_processinner ear development
A0050892biological_processintestinal absorption
A0050910biological_processdetection of mechanical stimulus involved in sensory perception of sound
A0055064biological_processchloride ion homeostasis
A0055075biological_processpotassium ion homeostasis
A0055085biological_processtransmembrane transport
A0060048biological_processcardiac muscle contraction
A0060117biological_processauditory receptor cell development
A0060306biological_processregulation of membrane repolarization
A0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
A0060372biological_processregulation of atrial cardiac muscle cell membrane repolarization
A0060452biological_processpositive regulation of cardiac muscle contraction
A0060453biological_processregulation of gastric acid secretion
A0061337biological_processcardiac conduction
A0062094biological_processstomach development
A0070293biological_processrenal absorption
A0070294biological_processrenal sodium ion absorption
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071805biological_processpotassium ion transmembrane transport
A0071872biological_processcellular response to epinephrine stimulus
A0071875biological_processadrenergic receptor signaling pathway
A0086003biological_processcardiac muscle cell contraction
A0086005biological_processventricular cardiac muscle cell action potential
A0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A0086009biological_processmembrane repolarization
A0086011biological_processmembrane repolarization during action potential
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086014biological_processatrial cardiac muscle cell action potential
A0086089molecular_functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
A0086091biological_processregulation of heart rate by cardiac conduction
A0090102biological_processcochlea development
A0097110molecular_functionscaffold protein binding
A0097546cellular_componentciliary base
A0097623biological_processpotassium ion export across plasma membrane
A0098576cellular_componentlumenal side of membrane
A0098914biological_processmembrane repolarization during atrial cardiac muscle cell action potential
A0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A1905515biological_processnon-motile cilium assembly
A1990573biological_processpotassium ion import across plasma membrane
A1990794cellular_componentbasolateral part of cell
B0001508biological_processaction potential
B0001696biological_processgastric acid secretion
B0001698biological_processgastrin-induced gastric acid secretion
B0002027biological_processregulation of heart rate
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006006biological_processglucose metabolic process
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0007507biological_processheart development
B0007605biological_processsensory perception of sound
B0007622biological_processrhythmic behavior
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0008157molecular_functionprotein phosphatase 1 binding
B0008217biological_processregulation of blood pressure
B0010460biological_processpositive regulation of heart rate
B0015271molecular_functionoutward rectifier potassium channel activity
B0015705biological_processiodide transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0022600biological_processdigestive system process
B0030133cellular_componenttransport vesicle
B0030218biological_processerythrocyte differentiation
B0030644biological_processintracellular chloride ion homeostasis
B0030659cellular_componentcytoplasmic vesicle membrane
B0032868biological_processresponse to insulin
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034702cellular_componentmonoatomic ion channel complex
B0034705cellular_componentpotassium channel complex
B0035176biological_processsocial behavior
B0035934biological_processcorticosterone secretion
B0042472biological_processinner ear morphogenesis
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0044325molecular_functiontransmembrane transporter binding
B0045121cellular_componentmembrane raft
B0045177cellular_componentapical part of cell
B0048839biological_processinner ear development
B0050892biological_processintestinal absorption
B0050910biological_processdetection of mechanical stimulus involved in sensory perception of sound
B0055064biological_processchloride ion homeostasis
B0055075biological_processpotassium ion homeostasis
B0055085biological_processtransmembrane transport
B0060048biological_processcardiac muscle contraction
B0060117biological_processauditory receptor cell development
B0060306biological_processregulation of membrane repolarization
B0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
B0060372biological_processregulation of atrial cardiac muscle cell membrane repolarization
B0060452biological_processpositive regulation of cardiac muscle contraction
B0060453biological_processregulation of gastric acid secretion
B0061337biological_processcardiac conduction
B0062094biological_processstomach development
B0070293biological_processrenal absorption
B0070294biological_processrenal sodium ion absorption
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071805biological_processpotassium ion transmembrane transport
B0071872biological_processcellular response to epinephrine stimulus
B0071875biological_processadrenergic receptor signaling pathway
B0086003biological_processcardiac muscle cell contraction
B0086005biological_processventricular cardiac muscle cell action potential
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086009biological_processmembrane repolarization
B0086011biological_processmembrane repolarization during action potential
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086014biological_processatrial cardiac muscle cell action potential
B0086089molecular_functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
B0086091biological_processregulation of heart rate by cardiac conduction
B0090102biological_processcochlea development
B0097110molecular_functionscaffold protein binding
B0097546cellular_componentciliary base
B0097623biological_processpotassium ion export across plasma membrane
B0098576cellular_componentlumenal side of membrane
B0098914biological_processmembrane repolarization during atrial cardiac muscle cell action potential
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B1905515biological_processnon-motile cilium assembly
B1990573biological_processpotassium ion import across plasma membrane
B1990794cellular_componentbasolateral part of cell
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0008179molecular_functionadenylate cyclase binding
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0031432molecular_functiontitin binding
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processpositive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
D0001508biological_processaction potential
D0001696biological_processgastric acid secretion
D0001698biological_processgastrin-induced gastric acid secretion
D0002027biological_processregulation of heart rate
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005770cellular_componentlate endosome
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006006biological_processglucose metabolic process
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0007507biological_processheart development
D0007605biological_processsensory perception of sound
D0007622biological_processrhythmic behavior
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0008157molecular_functionprotein phosphatase 1 binding
D0008217biological_processregulation of blood pressure
D0010460biological_processpositive regulation of heart rate
D0015271molecular_functionoutward rectifier potassium channel activity
D0015705biological_processiodide transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0022600biological_processdigestive system process
D0030133cellular_componenttransport vesicle
D0030218biological_processerythrocyte differentiation
D0030644biological_processintracellular chloride ion homeostasis
D0030659cellular_componentcytoplasmic vesicle membrane
D0032868biological_processresponse to insulin
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034702cellular_componentmonoatomic ion channel complex
D0034705cellular_componentpotassium channel complex
D0035176biological_processsocial behavior
D0035934biological_processcorticosterone secretion
D0042472biological_processinner ear morphogenesis
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0044325molecular_functiontransmembrane transporter binding
D0045121cellular_componentmembrane raft
D0045177cellular_componentapical part of cell
D0048839biological_processinner ear development
D0050892biological_processintestinal absorption
D0050910biological_processdetection of mechanical stimulus involved in sensory perception of sound
D0055064biological_processchloride ion homeostasis
D0055075biological_processpotassium ion homeostasis
D0055085biological_processtransmembrane transport
D0060048biological_processcardiac muscle contraction
D0060117biological_processauditory receptor cell development
D0060306biological_processregulation of membrane repolarization
D0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
D0060372biological_processregulation of atrial cardiac muscle cell membrane repolarization
D0060452biological_processpositive regulation of cardiac muscle contraction
D0060453biological_processregulation of gastric acid secretion
D0061337biological_processcardiac conduction
D0062094biological_processstomach development
D0070293biological_processrenal absorption
D0070294biological_processrenal sodium ion absorption
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071805biological_processpotassium ion transmembrane transport
D0071872biological_processcellular response to epinephrine stimulus
D0071875biological_processadrenergic receptor signaling pathway
D0086003biological_processcardiac muscle cell contraction
D0086005biological_processventricular cardiac muscle cell action potential
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086009biological_processmembrane repolarization
D0086011biological_processmembrane repolarization during action potential
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086014biological_processatrial cardiac muscle cell action potential
D0086089molecular_functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
D0086091biological_processregulation of heart rate by cardiac conduction
D0090102biological_processcochlea development
D0097110molecular_functionscaffold protein binding
D0097546cellular_componentciliary base
D0097623biological_processpotassium ion export across plasma membrane
D0098576cellular_componentlumenal side of membrane
D0098914biological_processmembrane repolarization during atrial cardiac muscle cell action potential
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D1905515biological_processnon-motile cilium assembly
D1990573biological_processpotassium ion import across plasma membrane
D1990794cellular_componentbasolateral part of cell
E0000086biological_processG2/M transition of mitotic cell cycle
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005856cellular_componentcytoskeleton
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0007186biological_processG protein-coupled receptor signaling pathway
E0008076cellular_componentvoltage-gated potassium channel complex
E0008179molecular_functionadenylate cyclase binding
E0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
E0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0031432molecular_functiontitin binding
E0031954biological_processpositive regulation of protein autophosphorylation
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032516biological_processpositive regulation of phosphoprotein phosphatase activity
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035307biological_processpositive regulation of protein dephosphorylation
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044325molecular_functiontransmembrane transporter binding
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050848biological_processregulation of calcium-mediated signaling
E0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0098901biological_processregulation of cardiac muscle cell action potential
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0008179molecular_functionadenylate cyclase binding
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0031432molecular_functiontitin binding
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
G0001508biological_processaction potential
G0001696biological_processgastric acid secretion
G0001698biological_processgastrin-induced gastric acid secretion
G0002027biological_processregulation of heart rate
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005251molecular_functiondelayed rectifier potassium channel activity
G0005267molecular_functionpotassium channel activity
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005768cellular_componentendosome
G0005769cellular_componentearly endosome
G0005770cellular_componentlate endosome
G0005783cellular_componentendoplasmic reticulum
G0005886cellular_componentplasma membrane
G0006006biological_processglucose metabolic process
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006814biological_processsodium ion transport
G0007507biological_processheart development
G0007605biological_processsensory perception of sound
G0007622biological_processrhythmic behavior
G0008016biological_processregulation of heart contraction
G0008076cellular_componentvoltage-gated potassium channel complex
G0008157molecular_functionprotein phosphatase 1 binding
G0008217biological_processregulation of blood pressure
G0010460biological_processpositive regulation of heart rate
G0015271molecular_functionoutward rectifier potassium channel activity
G0015705biological_processiodide transport
G0016020cellular_componentmembrane
G0016323cellular_componentbasolateral plasma membrane
G0016324cellular_componentapical plasma membrane
G0022600biological_processdigestive system process
G0030133cellular_componenttransport vesicle
G0030218biological_processerythrocyte differentiation
G0030644biological_processintracellular chloride ion homeostasis
G0030659cellular_componentcytoplasmic vesicle membrane
G0032868biological_processresponse to insulin
G0034236molecular_functionprotein kinase A catalytic subunit binding
G0034237molecular_functionprotein kinase A regulatory subunit binding
G0034702cellular_componentmonoatomic ion channel complex
G0034705cellular_componentpotassium channel complex
G0035176biological_processsocial behavior
G0035934biological_processcorticosterone secretion
G0042472biological_processinner ear morphogenesis
G0043005cellular_componentneuron projection
G0043025cellular_componentneuronal cell body
G0044325molecular_functiontransmembrane transporter binding
G0045121cellular_componentmembrane raft
G0045177cellular_componentapical part of cell
G0048839biological_processinner ear development
G0050892biological_processintestinal absorption
G0050910biological_processdetection of mechanical stimulus involved in sensory perception of sound
G0055064biological_processchloride ion homeostasis
G0055075biological_processpotassium ion homeostasis
G0055085biological_processtransmembrane transport
G0060048biological_processcardiac muscle contraction
G0060117biological_processauditory receptor cell development
G0060306biological_processregulation of membrane repolarization
G0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
G0060372biological_processregulation of atrial cardiac muscle cell membrane repolarization
G0060452biological_processpositive regulation of cardiac muscle contraction
G0060453biological_processregulation of gastric acid secretion
G0061337biological_processcardiac conduction
G0062094biological_processstomach development
G0070293biological_processrenal absorption
G0070294biological_processrenal sodium ion absorption
G0071320biological_processcellular response to cAMP
G0071466biological_processcellular response to xenobiotic stimulus
G0071805biological_processpotassium ion transmembrane transport
G0071872biological_processcellular response to epinephrine stimulus
G0071875biological_processadrenergic receptor signaling pathway
G0086003biological_processcardiac muscle cell contraction
G0086005biological_processventricular cardiac muscle cell action potential
G0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
G0086009biological_processmembrane repolarization
G0086011biological_processmembrane repolarization during action potential
G0086013biological_processmembrane repolarization during cardiac muscle cell action potential
G0086014biological_processatrial cardiac muscle cell action potential
G0086089molecular_functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
G0086091biological_processregulation of heart rate by cardiac conduction
G0090102biological_processcochlea development
G0097110molecular_functionscaffold protein binding
G0097546cellular_componentciliary base
G0097623biological_processpotassium ion export across plasma membrane
G0098576cellular_componentlumenal side of membrane
G0098914biological_processmembrane repolarization during atrial cardiac muscle cell action potential
G0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
G1901381biological_processpositive regulation of potassium ion transmembrane transport
G1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G1905515biological_processnon-motile cilium assembly
G1990573biological_processpotassium ion import across plasma membrane
G1990794cellular_componentbasolateral part of cell
H0000086biological_processG2/M transition of mitotic cell cycle
H0000922cellular_componentspindle pole
H0002027biological_processregulation of heart rate
H0005509molecular_functioncalcium ion binding
H0005513biological_processdetection of calcium ion
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005856cellular_componentcytoskeleton
H0005876cellular_componentspindle microtubule
H0005886cellular_componentplasma membrane
H0007186biological_processG protein-coupled receptor signaling pathway
H0008076cellular_componentvoltage-gated potassium channel complex
H0008179molecular_functionadenylate cyclase binding
H0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
H0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
H0010856molecular_functionadenylate cyclase activator activity
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030017cellular_componentsarcomere
H0031432molecular_functiontitin binding
H0031954biological_processpositive regulation of protein autophosphorylation
H0031982cellular_componentvesicle
H0032465biological_processregulation of cytokinesis
H0032516biological_processpositive regulation of phosphoprotein phosphatase activity
H0032991cellular_componentprotein-containing complex
H0034704cellular_componentcalcium channel complex
H0035307biological_processpositive regulation of protein dephosphorylation
H0043209cellular_componentmyelin sheath
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0044325molecular_functiontransmembrane transporter binding
H0046872molecular_functionmetal ion binding
H0048306molecular_functioncalcium-dependent protein binding
H0050848biological_processregulation of calcium-mediated signaling
H0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
H0051592biological_processresponse to calcium ion
H0055117biological_processregulation of cardiac muscle contraction
H0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
H0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0072542molecular_functionprotein phosphatase activator activity
H0097225cellular_componentsperm midpiece
H0098901biological_processregulation of cardiac muscle cell action potential
H1901842biological_processnegative regulation of high voltage-gated calcium channel activity
H1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
H1902494cellular_componentcatalytic complex
H1905913biological_processnegative regulation of calcium ion export across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
CASP21-LEU33
CASP57-PHE69
CASP94-LEU106
CASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585
ChainResidueDetails
CASP21
CASP23
CASP25
CTHR27
CGLU32
CASP57
CASP59
CASN61
CTHR63
CGLU68
CASP94
CASP96
CASN98
CTYR100
CGLU105
CASP130
CASP132
CASP134
CGLN136
CGLU141
EASP21
EASP23
EASP25
ETHR27
EGLU32
EASP57
EASP59
EASN61
ETHR63
EGLU68
EASP94
EASP96
EASN98
ETYR100
EGLU105
EASP130
EASP132
EASP134
EGLN136
EGLU141
FASP21
FASP23
FASP25
FTHR27
FGLU32
FASP57
FASP59
FASN61
FTHR63
FGLU68
FASP94
FASP96
FASN98
FTYR100
FGLU105
FASP130
FASP132
FASP134
FGLN136
FGLU141
HASP21
HASP23
HASP25
HTHR27
HGLU32
HASP57
HASP59
HASN61
HTHR63
HGLU68
HASP94
HASP96
HASN98
HTYR100
HGLU105
HASP130
HASP132
HASP134
HGLN136
HGLU141

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
CALA2
EALA2
FALA2
HALA2

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS22
ELYS22
FLYS22
HLYS22
BSER143-GLN147
BLYS218-SER225
BALA283-TYR299
BGLN321-THR327
DSER143-GLN147
DLYS218-SER225
DALA283-TYR299
DGLN321-THR327
GSER143-GLN147
GLYS218-SER225
GALA283-TYR299
GGLN321-THR327

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP31
ChainResidueDetails
CTHR45
ETHR45
FTHR45
HTHR45

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER82
ESER82
FSER82
HSER82

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS95
ELYS95
FLYS95
HLYS95

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR100
ETYR100
FTYR100
HTYR100

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER102
ESER102
FSER102
HSER102

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR111
ETHR111
FTHR111
HTHR111

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
CLYS116
ELYS116
FLYS116
HLYS116

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR139
ETYR139
FTYR139
HTYR139
DSER407
DSER409
GSER407
GSER409

site_idSWS_FT_FI12
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
CLYS22
BASN289
ELYS22
GASN289
FLYS22
HLYS22

220472

PDB entries from 2024-05-29

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