7XNI

human KCNQ1-CaM in apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0001696	biological_process	gastric acid secretion
A	0001698	biological_process	gastrin-induced gastric acid secretion
A	0002027	biological_process	regulation of heart rate
A	0003008	biological_process	system process
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005251	molecular_function	delayed rectifier potassium channel activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0007507	biological_process	heart development
A	0007605	biological_process	sensory perception of sound
A	0007622	biological_process	rhythmic behavior
A	0008016	biological_process	regulation of heart contraction
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008157	molecular_function	protein phosphatase 1 binding
A	0008217	biological_process	regulation of blood pressure
A	0010460	biological_process	positive regulation of heart rate
A	0012505	cellular_component	endomembrane system
A	0015271	molecular_function	outward rectifier potassium channel activity
A	0015705	biological_process	iodide transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0030133	cellular_component	transport vesicle
A	0030218	biological_process	erythrocyte differentiation
A	0030644	biological_process	intracellular chloride ion homeostasis
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032868	biological_process	response to insulin
A	0034236	molecular_function	protein kinase A catalytic subunit binding
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034702	cellular_component	monoatomic ion channel complex
A	0034705	cellular_component	potassium channel complex
A	0035176	biological_process	social behavior
A	0035934	biological_process	corticosterone secretion
A	0042391	biological_process	regulation of membrane potential
A	0042472	biological_process	inner ear morphogenesis
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0044325	molecular_function	transmembrane transporter binding
A	0045121	cellular_component	membrane raft
A	0045177	cellular_component	apical part of cell
A	0045178	cellular_component	basal part of cell
A	0048839	biological_process	inner ear development
A	0050892	biological_process	intestinal absorption
A	0050905	biological_process	neuromuscular process
A	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
A	0051049	biological_process	regulation of transport
A	0055064	biological_process	chloride ion homeostasis
A	0055075	biological_process	potassium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0060048	biological_process	cardiac muscle contraction
A	0060117	biological_process	auditory receptor cell development
A	0060306	biological_process	regulation of membrane repolarization
A	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
A	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
A	0060452	biological_process	positive regulation of cardiac muscle contraction
A	0060453	biological_process	regulation of gastric acid secretion
A	0061337	biological_process	cardiac conduction
A	0062094	biological_process	stomach development
A	0070293	biological_process	renal absorption
A	0070294	biological_process	renal sodium ion absorption
A	0071320	biological_process	cellular response to cAMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071805	biological_process	potassium ion transmembrane transport
A	0071872	biological_process	cellular response to epinephrine stimulus
A	0071875	biological_process	adrenergic receptor signaling pathway
A	0086003	biological_process	cardiac muscle cell contraction
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A	0086009	biological_process	membrane repolarization
A	0086011	biological_process	membrane repolarization during action potential
A	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
A	0086014	biological_process	atrial cardiac muscle cell action potential
A	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0090102	biological_process	cochlea development
A	0097110	molecular_function	scaffold protein binding
A	0097546	cellular_component	ciliary base
A	0097623	biological_process	potassium ion export across plasma membrane
A	0098576	cellular_component	lumenal side of membrane
A	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
A	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
A	1901381	biological_process	positive regulation of potassium ion transmembrane transport
A	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A	1905515	biological_process	non-motile cilium assembly
A	1990573	biological_process	potassium ion import across plasma membrane
A	1990794	cellular_component	basolateral part of cell
B	0001508	biological_process	action potential
B	0001696	biological_process	gastric acid secretion
B	0001698	biological_process	gastrin-induced gastric acid secretion
B	0002027	biological_process	regulation of heart rate
B	0003008	biological_process	system process
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005251	molecular_function	delayed rectifier potassium channel activity
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005769	cellular_component	early endosome
B	0005770	cellular_component	late endosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0006006	biological_process	glucose metabolic process
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0007507	biological_process	heart development
B	0007605	biological_process	sensory perception of sound
B	0007622	biological_process	rhythmic behavior
B	0008016	biological_process	regulation of heart contraction
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0008157	molecular_function	protein phosphatase 1 binding
B	0008217	biological_process	regulation of blood pressure
B	0010460	biological_process	positive regulation of heart rate
B	0012505	cellular_component	endomembrane system
B	0015271	molecular_function	outward rectifier potassium channel activity
B	0015705	biological_process	iodide transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0030133	cellular_component	transport vesicle
B	0030218	biological_process	erythrocyte differentiation
B	0030644	biological_process	intracellular chloride ion homeostasis
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032868	biological_process	response to insulin
B	0034236	molecular_function	protein kinase A catalytic subunit binding
B	0034237	molecular_function	protein kinase A regulatory subunit binding
B	0034702	cellular_component	monoatomic ion channel complex
B	0034705	cellular_component	potassium channel complex
B	0035176	biological_process	social behavior
B	0035934	biological_process	corticosterone secretion
B	0042391	biological_process	regulation of membrane potential
B	0042472	biological_process	inner ear morphogenesis
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0044325	molecular_function	transmembrane transporter binding
B	0045121	cellular_component	membrane raft
B	0045177	cellular_component	apical part of cell
B	0045178	cellular_component	basal part of cell
B	0048839	biological_process	inner ear development
B	0050892	biological_process	intestinal absorption
B	0050905	biological_process	neuromuscular process
B	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
B	0051049	biological_process	regulation of transport
B	0055064	biological_process	chloride ion homeostasis
B	0055075	biological_process	potassium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0060048	biological_process	cardiac muscle contraction
B	0060117	biological_process	auditory receptor cell development
B	0060306	biological_process	regulation of membrane repolarization
B	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
B	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
B	0060452	biological_process	positive regulation of cardiac muscle contraction
B	0060453	biological_process	regulation of gastric acid secretion
B	0061337	biological_process	cardiac conduction
B	0062094	biological_process	stomach development
B	0070293	biological_process	renal absorption
B	0070294	biological_process	renal sodium ion absorption
B	0071320	biological_process	cellular response to cAMP
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071805	biological_process	potassium ion transmembrane transport
B	0071872	biological_process	cellular response to epinephrine stimulus
B	0071875	biological_process	adrenergic receptor signaling pathway
B	0086003	biological_process	cardiac muscle cell contraction
B	0086005	biological_process	ventricular cardiac muscle cell action potential
B	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B	0086009	biological_process	membrane repolarization
B	0086011	biological_process	membrane repolarization during action potential
B	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
B	0086014	biological_process	atrial cardiac muscle cell action potential
B	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
B	0086091	biological_process	regulation of heart rate by cardiac conduction
B	0090102	biological_process	cochlea development
B	0097110	molecular_function	scaffold protein binding
B	0097546	cellular_component	ciliary base
B	0097623	biological_process	potassium ion export across plasma membrane
B	0098576	cellular_component	lumenal side of membrane
B	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
B	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
B	1901381	biological_process	positive regulation of potassium ion transmembrane transport
B	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B	1905515	biological_process	non-motile cilium assembly
B	1990573	biological_process	potassium ion import across plasma membrane
B	1990794	cellular_component	basolateral part of cell
C	0000785	cellular_component	chromatin
C	0000922	cellular_component	spindle pole
C	0001975	biological_process	response to amphetamine
C	0002027	biological_process	regulation of heart rate
C	0005246	molecular_function	calcium channel regulator activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005876	cellular_component	spindle microtubule
C	0005886	cellular_component	plasma membrane
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008179	molecular_function	adenylate cyclase binding
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0021762	biological_process	substantia nigra development
C	0030017	cellular_component	sarcomere
C	0030235	molecular_function	nitric-oxide synthase regulator activity
C	0030426	cellular_component	growth cone
C	0030672	cellular_component	synaptic vesicle membrane
C	0031432	molecular_function	titin binding
C	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
C	0031966	cellular_component	mitochondrial membrane
C	0031982	cellular_component	vesicle
C	0032465	biological_process	regulation of cytokinesis
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0043548	molecular_function	phosphatidylinositol 3-kinase binding
C	0044305	cellular_component	calyx of Held
C	0044325	molecular_function	transmembrane transporter binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050998	molecular_function	nitric-oxide synthase binding
C	0051412	biological_process	response to corticosterone
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060291	biological_process	long-term synaptic potentiation
C	0072542	molecular_function	protein phosphatase activator activity
C	0097225	cellular_component	sperm midpiece
C	0097720	biological_process	calcineurin-mediated signaling
C	0098685	cellular_component	Schaffer collateral - CA1 synapse
C	0098901	biological_process	regulation of cardiac muscle cell action potential
C	0099523	cellular_component	presynaptic cytosol
C	0099524	cellular_component	postsynaptic cytosol
C	0140238	biological_process	presynaptic endocytosis
C	0141110	molecular_function	transporter inhibitor activity
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	1902494	cellular_component	catalytic complex
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	2000300	biological_process	regulation of synaptic vesicle exocytosis
D	0001508	biological_process	action potential
D	0001696	biological_process	gastric acid secretion
D	0001698	biological_process	gastrin-induced gastric acid secretion
D	0002027	biological_process	regulation of heart rate
D	0003008	biological_process	system process
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005251	molecular_function	delayed rectifier potassium channel activity
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005769	cellular_component	early endosome
D	0005770	cellular_component	late endosome
D	0005783	cellular_component	endoplasmic reticulum
D	0005886	cellular_component	plasma membrane
D	0006006	biological_process	glucose metabolic process
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0007507	biological_process	heart development
D	0007605	biological_process	sensory perception of sound
D	0007622	biological_process	rhythmic behavior
D	0008016	biological_process	regulation of heart contraction
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0008157	molecular_function	protein phosphatase 1 binding
D	0008217	biological_process	regulation of blood pressure
D	0010460	biological_process	positive regulation of heart rate
D	0012505	cellular_component	endomembrane system
D	0015271	molecular_function	outward rectifier potassium channel activity
D	0015705	biological_process	iodide transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0016324	cellular_component	apical plasma membrane
D	0030133	cellular_component	transport vesicle
D	0030218	biological_process	erythrocyte differentiation
D	0030644	biological_process	intracellular chloride ion homeostasis
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032868	biological_process	response to insulin
D	0034236	molecular_function	protein kinase A catalytic subunit binding
D	0034237	molecular_function	protein kinase A regulatory subunit binding
D	0034702	cellular_component	monoatomic ion channel complex
D	0034705	cellular_component	potassium channel complex
D	0035176	biological_process	social behavior
D	0035934	biological_process	corticosterone secretion
D	0042391	biological_process	regulation of membrane potential
D	0042472	biological_process	inner ear morphogenesis
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0044325	molecular_function	transmembrane transporter binding
D	0045121	cellular_component	membrane raft
D	0045177	cellular_component	apical part of cell
D	0045178	cellular_component	basal part of cell
D	0048839	biological_process	inner ear development
D	0050892	biological_process	intestinal absorption
D	0050905	biological_process	neuromuscular process
D	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
D	0051049	biological_process	regulation of transport
D	0055064	biological_process	chloride ion homeostasis
D	0055075	biological_process	potassium ion homeostasis
D	0055085	biological_process	transmembrane transport
D	0060048	biological_process	cardiac muscle contraction
D	0060117	biological_process	auditory receptor cell development
D	0060306	biological_process	regulation of membrane repolarization
D	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
D	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
D	0060452	biological_process	positive regulation of cardiac muscle contraction
D	0060453	biological_process	regulation of gastric acid secretion
D	0061337	biological_process	cardiac conduction
D	0062094	biological_process	stomach development
D	0070293	biological_process	renal absorption
D	0070294	biological_process	renal sodium ion absorption
D	0071320	biological_process	cellular response to cAMP
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071805	biological_process	potassium ion transmembrane transport
D	0071872	biological_process	cellular response to epinephrine stimulus
D	0071875	biological_process	adrenergic receptor signaling pathway
D	0086003	biological_process	cardiac muscle cell contraction
D	0086005	biological_process	ventricular cardiac muscle cell action potential
D	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D	0086009	biological_process	membrane repolarization
D	0086011	biological_process	membrane repolarization during action potential
D	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
D	0086014	biological_process	atrial cardiac muscle cell action potential
D	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
D	0086091	biological_process	regulation of heart rate by cardiac conduction
D	0090102	biological_process	cochlea development
D	0097110	molecular_function	scaffold protein binding
D	0097546	cellular_component	ciliary base
D	0097623	biological_process	potassium ion export across plasma membrane
D	0098576	cellular_component	lumenal side of membrane
D	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
D	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
D	1901381	biological_process	positive regulation of potassium ion transmembrane transport
D	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D	1905515	biological_process	non-motile cilium assembly
D	1990573	biological_process	potassium ion import across plasma membrane
D	1990794	cellular_component	basolateral part of cell
E	0000785	cellular_component	chromatin
E	0000922	cellular_component	spindle pole
E	0001975	biological_process	response to amphetamine
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008179	molecular_function	adenylate cyclase binding
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030426	cellular_component	growth cone
E	0030672	cellular_component	synaptic vesicle membrane
E	0031432	molecular_function	titin binding
E	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
E	0031966	cellular_component	mitochondrial membrane
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0043548	molecular_function	phosphatidylinositol 3-kinase binding
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050998	molecular_function	nitric-oxide synthase binding
E	0051412	biological_process	response to corticosterone
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060291	biological_process	long-term synaptic potentiation
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0099524	cellular_component	postsynaptic cytosol
E	0140238	biological_process	presynaptic endocytosis
E	0141110	molecular_function	transporter inhibitor activity
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	2000300	biological_process	regulation of synaptic vesicle exocytosis
F	0000785	cellular_component	chromatin
F	0000922	cellular_component	spindle pole
F	0001975	biological_process	response to amphetamine
F	0002027	biological_process	regulation of heart rate
F	0005246	molecular_function	calcium channel regulator activity
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005876	cellular_component	spindle microtubule
F	0005886	cellular_component	plasma membrane
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0008179	molecular_function	adenylate cyclase binding
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0019901	molecular_function	protein kinase binding
F	0019904	molecular_function	protein domain specific binding
F	0021762	biological_process	substantia nigra development
F	0030017	cellular_component	sarcomere
F	0030235	molecular_function	nitric-oxide synthase regulator activity
F	0030426	cellular_component	growth cone
F	0030672	cellular_component	synaptic vesicle membrane
F	0031432	molecular_function	titin binding
F	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
F	0031966	cellular_component	mitochondrial membrane
F	0031982	cellular_component	vesicle
F	0032465	biological_process	regulation of cytokinesis
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0043548	molecular_function	phosphatidylinositol 3-kinase binding
F	0044305	cellular_component	calyx of Held
F	0044325	molecular_function	transmembrane transporter binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050998	molecular_function	nitric-oxide synthase binding
F	0051412	biological_process	response to corticosterone
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060291	biological_process	long-term synaptic potentiation
F	0072542	molecular_function	protein phosphatase activator activity
F	0097225	cellular_component	sperm midpiece
F	0097720	biological_process	calcineurin-mediated signaling
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0099523	cellular_component	presynaptic cytosol
F	0099524	cellular_component	postsynaptic cytosol
F	0140238	biological_process	presynaptic endocytosis
F	0141110	molecular_function	transporter inhibitor activity
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
F	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
F	1902494	cellular_component	catalytic complex
F	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
F	2000300	biological_process	regulation of synaptic vesicle exocytosis
G	0001508	biological_process	action potential
G	0001696	biological_process	gastric acid secretion
G	0001698	biological_process	gastrin-induced gastric acid secretion
G	0002027	biological_process	regulation of heart rate
G	0003008	biological_process	system process
G	0005216	molecular_function	monoatomic ion channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005251	molecular_function	delayed rectifier potassium channel activity
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005769	cellular_component	early endosome
G	0005770	cellular_component	late endosome
G	0005783	cellular_component	endoplasmic reticulum
G	0005886	cellular_component	plasma membrane
G	0006006	biological_process	glucose metabolic process
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0006814	biological_process	sodium ion transport
G	0007507	biological_process	heart development
G	0007605	biological_process	sensory perception of sound
G	0007622	biological_process	rhythmic behavior
G	0008016	biological_process	regulation of heart contraction
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008157	molecular_function	protein phosphatase 1 binding
G	0008217	biological_process	regulation of blood pressure
G	0010460	biological_process	positive regulation of heart rate
G	0012505	cellular_component	endomembrane system
G	0015271	molecular_function	outward rectifier potassium channel activity
G	0015705	biological_process	iodide transport
G	0016020	cellular_component	membrane
G	0016323	cellular_component	basolateral plasma membrane
G	0016324	cellular_component	apical plasma membrane
G	0030133	cellular_component	transport vesicle
G	0030218	biological_process	erythrocyte differentiation
G	0030644	biological_process	intracellular chloride ion homeostasis
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032868	biological_process	response to insulin
G	0034236	molecular_function	protein kinase A catalytic subunit binding
G	0034237	molecular_function	protein kinase A regulatory subunit binding
G	0034702	cellular_component	monoatomic ion channel complex
G	0034705	cellular_component	potassium channel complex
G	0035176	biological_process	social behavior
G	0035934	biological_process	corticosterone secretion
G	0042391	biological_process	regulation of membrane potential
G	0042472	biological_process	inner ear morphogenesis
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0044325	molecular_function	transmembrane transporter binding
G	0045121	cellular_component	membrane raft
G	0045177	cellular_component	apical part of cell
G	0045178	cellular_component	basal part of cell
G	0048839	biological_process	inner ear development
G	0050892	biological_process	intestinal absorption
G	0050905	biological_process	neuromuscular process
G	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
G	0051049	biological_process	regulation of transport
G	0055064	biological_process	chloride ion homeostasis
G	0055075	biological_process	potassium ion homeostasis
G	0055085	biological_process	transmembrane transport
G	0060048	biological_process	cardiac muscle contraction
G	0060117	biological_process	auditory receptor cell development
G	0060306	biological_process	regulation of membrane repolarization
G	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
G	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
G	0060452	biological_process	positive regulation of cardiac muscle contraction
G	0060453	biological_process	regulation of gastric acid secretion
G	0061337	biological_process	cardiac conduction
G	0062094	biological_process	stomach development
G	0070293	biological_process	renal absorption
G	0070294	biological_process	renal sodium ion absorption
G	0071320	biological_process	cellular response to cAMP
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	0071805	biological_process	potassium ion transmembrane transport
G	0071872	biological_process	cellular response to epinephrine stimulus
G	0071875	biological_process	adrenergic receptor signaling pathway
G	0086003	biological_process	cardiac muscle cell contraction
G	0086005	biological_process	ventricular cardiac muscle cell action potential
G	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
G	0086009	biological_process	membrane repolarization
G	0086011	biological_process	membrane repolarization during action potential
G	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
G	0086014	biological_process	atrial cardiac muscle cell action potential
G	0086089	molecular_function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
G	0086091	biological_process	regulation of heart rate by cardiac conduction
G	0090102	biological_process	cochlea development
G	0097110	molecular_function	scaffold protein binding
G	0097546	cellular_component	ciliary base
G	0097623	biological_process	potassium ion export across plasma membrane
G	0098576	cellular_component	lumenal side of membrane
G	0098914	biological_process	membrane repolarization during atrial cardiac muscle cell action potential
G	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
G	1901381	biological_process	positive regulation of potassium ion transmembrane transport
G	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
G	1905515	biological_process	non-motile cilium assembly
G	1990573	biological_process	potassium ion import across plasma membrane
G	1990794	cellular_component	basolateral part of cell
H	0000785	cellular_component	chromatin
H	0000922	cellular_component	spindle pole
H	0001975	biological_process	response to amphetamine
H	0002027	biological_process	regulation of heart rate
H	0005246	molecular_function	calcium channel regulator activity
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0008179	molecular_function	adenylate cyclase binding
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0019901	molecular_function	protein kinase binding
H	0019904	molecular_function	protein domain specific binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030426	cellular_component	growth cone
H	0030672	cellular_component	synaptic vesicle membrane
H	0031432	molecular_function	titin binding
H	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
H	0031966	cellular_component	mitochondrial membrane
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0043548	molecular_function	phosphatidylinositol 3-kinase binding
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051412	biological_process	response to corticosterone
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060291	biological_process	long-term synaptic potentiation
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0099524	cellular_component	postsynaptic cytosol
H	0140238	biological_process	presynaptic endocytosis
H	0141110	molecular_function	transporter inhibitor activity
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
C	ASP21-LEU33
C	ASP57-PHE69
C	ASP94-LEU106
C	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	104
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	32
Details	Region: {"description":"Interaction with KCNE3","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	48
Details	Region: {"description":"Interaction with CALM","evidences":[{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	56
Details	Region: {"description":"Interaction with CALM; calcium-dependent","evidences":[{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	128
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	288
Details	Region: {"description":"Necessary and sufficient for interaction with PCP4","evidences":[{"source":"PubMed","id":"27876793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP31","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---