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7XKI

Human Cx36/GJD2 (N-terminal deletion BRIL-fused mutant) gap junction channel in soybean lipids (D6 symmetry)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005506molecular_functioniron ion binding
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0009055molecular_functionelectron transfer activity
A0020037molecular_functionheme binding
A0022900biological_processelectron transport chain
A0042597cellular_componentperiplasmic space
A0046872molecular_functionmetal ion binding
B0005506molecular_functioniron ion binding
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0009055molecular_functionelectron transfer activity
B0020037molecular_functionheme binding
B0022900biological_processelectron transport chain
B0042597cellular_componentperiplasmic space
B0046872molecular_functionmetal ion binding
C0005506molecular_functioniron ion binding
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0009055molecular_functionelectron transfer activity
C0020037molecular_functionheme binding
C0022900biological_processelectron transport chain
C0042597cellular_componentperiplasmic space
C0046872molecular_functionmetal ion binding
D0005506molecular_functioniron ion binding
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0009055molecular_functionelectron transfer activity
D0020037molecular_functionheme binding
D0022900biological_processelectron transport chain
D0042597cellular_componentperiplasmic space
D0046872molecular_functionmetal ion binding
E0005506molecular_functioniron ion binding
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0009055molecular_functionelectron transfer activity
E0020037molecular_functionheme binding
E0022900biological_processelectron transport chain
E0042597cellular_componentperiplasmic space
E0046872molecular_functionmetal ion binding
F0005506molecular_functioniron ion binding
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0009055molecular_functionelectron transfer activity
F0020037molecular_functionheme binding
F0022900biological_processelectron transport chain
F0042597cellular_componentperiplasmic space
F0046872molecular_functionmetal ion binding
G0005506molecular_functioniron ion binding
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0009055molecular_functionelectron transfer activity
G0020037molecular_functionheme binding
G0022900biological_processelectron transport chain
G0042597cellular_componentperiplasmic space
G0046872molecular_functionmetal ion binding
H0005506molecular_functioniron ion binding
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0009055molecular_functionelectron transfer activity
H0020037molecular_functionheme binding
H0022900biological_processelectron transport chain
H0042597cellular_componentperiplasmic space
H0046872molecular_functionmetal ion binding
I0005506molecular_functioniron ion binding
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0009055molecular_functionelectron transfer activity
I0020037molecular_functionheme binding
I0022900biological_processelectron transport chain
I0042597cellular_componentperiplasmic space
I0046872molecular_functionmetal ion binding
J0005506molecular_functioniron ion binding
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0009055molecular_functionelectron transfer activity
J0020037molecular_functionheme binding
J0022900biological_processelectron transport chain
J0042597cellular_componentperiplasmic space
J0046872molecular_functionmetal ion binding
K0005506molecular_functioniron ion binding
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0009055molecular_functionelectron transfer activity
K0020037molecular_functionheme binding
K0022900biological_processelectron transport chain
K0042597cellular_componentperiplasmic space
K0046872molecular_functionmetal ion binding
L0005506molecular_functioniron ion binding
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0009055molecular_functionelectron transfer activity
L0020037molecular_functionheme binding
L0022900biological_processelectron transport chain
L0042597cellular_componentperiplasmic space
L0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCnqACYD
ChainResidueDetails
ACYS55-ASP68

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cnry.PCikeVECYVSRP
ChainResidueDetails
ACYS231-PRO247

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues756
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET16-ARG34
EGLY276-VAL321
FMET16-ARG34
FGLY276-VAL321
GMET16-ARG34
GGLY276-VAL321
HMET16-ARG34
HGLY276-VAL321
IMET16-ARG34
IGLY276-VAL321
JMET16-ARG34
AGLY276-VAL321
JGLY276-VAL321
KMET16-ARG34
KGLY276-VAL321
LMET16-ARG34
LGLY276-VAL321
BMET16-ARG34
BGLY276-VAL321
CMET16-ARG34
CGLY276-VAL321
DMET16-ARG34
DGLY276-VAL321
EMET16-ARG34

site_idSWS_FT_FI2
Number of Residues1056
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AILE35-THR57
CLEU91-ASP101
CPHE198-LEU220
CPHE253-LEU275
DILE35-THR57
DLEU91-ASP101
DPHE198-LEU220
DPHE253-LEU275
EILE35-THR57
ELEU91-ASP101
EPHE198-LEU220
ALEU91-ASP101
EPHE253-LEU275
FILE35-THR57
FLEU91-ASP101
FPHE198-LEU220
FPHE253-LEU275
GILE35-THR57
GLEU91-ASP101
GPHE198-LEU220
GPHE253-LEU275
HILE35-THR57
APHE198-LEU220
HLEU91-ASP101
HPHE198-LEU220
HPHE253-LEU275
IILE35-THR57
ILEU91-ASP101
IPHE198-LEU220
IPHE253-LEU275
JILE35-THR57
JLEU91-ASP101
JPHE198-LEU220
APHE253-LEU275
JPHE253-LEU275
KILE35-THR57
KLEU91-ASP101
KPHE198-LEU220
KPHE253-LEU275
LILE35-THR57
LLEU91-ASP101
LPHE198-LEU220
LPHE253-LEU275
BILE35-THR57
BLEU91-ASP101
BPHE198-LEU220
BPHE253-LEU275
CILE35-THR57

site_idSWS_FT_FI3
Number of Residues756
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ALEU58-SER90
ETYR221-VAL252
FLEU58-SER90
FTYR221-VAL252
GLEU58-SER90
GTYR221-VAL252
HLEU58-SER90
HTYR221-VAL252
ILEU58-SER90
ITYR221-VAL252
JLEU58-SER90
ATYR221-VAL252
JTYR221-VAL252
KLEU58-SER90
KTYR221-VAL252
LLEU58-SER90
LTYR221-VAL252
BLEU58-SER90
BTYR221-VAL252
CLEU58-SER90
CTYR221-VAL252
DLEU58-SER90
DTYR221-VAL252
ELEU58-SER90

site_idSWS_FT_FI4
Number of Residues24
DetailsBINDING: axial binding residue
ChainResidueDetails
ATRP101
EILE105
FTRP101
FILE105
GTRP101
GILE105
HTRP101
HILE105
ITRP101
IILE105
JTRP101
AILE105
JILE105
KTRP101
KILE105
LTRP101
LILE105
BTRP101
BILE105
CTRP101
CILE105
DTRP101
DILE105
ETRP101

222624

PDB entries from 2024-07-17

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