7XKE
Cryo-EM structure of DHEA-ADGRG2-FL-Gs complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| B | 1903561 | cellular_component | extracellular vesicle |
| G | 0005834 | cellular_component | heterotrimeric G-protein complex |
| G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| G | 0031681 | molecular_function | G-protein beta-subunit binding |
| R | 0004888 | molecular_function | transmembrane signaling receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFFIfIFYCAaKenV |
| Chain | Residue | Details |
| R | GLN863-VAL878 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 614 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| R | LEU38-ALA619 | |
| R | ASN681-ARG683 | |
| R | ASP751-THR781 | |
| R | VAL848-ASN849 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU620-VAL640 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 65 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| R | THR641-GLN659 | |
| R | GLY705-LYS729 | |
| R | GLN803-SER826 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU660-TYR680 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY684-MET704 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | PHE730-PRO750 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL782-VAL802 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | ILE827-PRO847 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL850-PHE870 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000255|PROSITE-ProRule:PRU00098 |
| Chain | Residue | Details |
| R | LEU598 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN43 | |
| R | ASN186 | |
| R | ASN362 | |
| R | ASN427 | |
| R | ASN448 | |
| R | ASN453 | |
| R | ASN520 | |
| R | ASN534 | |
| R | ASN539 | |
| R | ASN543 | |
| R | ASN589 | |
| R | ASN77 | |
| R | ASN849 | |
| R | ASN91 | |
| R | ASN103 | |
| R | ASN109 | |
| R | ASN127 | |
| R | ASN136 | |
| R | ASN154 | |
| R | ASN178 |
