7X3T

Cryo-EM structure of ISW1a-dinucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0030527	molecular_function	structural constituent of chromatin
K	0046982	molecular_function	protein heterodimerization activity
L	0000786	cellular_component	nucleosome
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0006334	biological_process	nucleosome assembly
L	0030527	molecular_function	structural constituent of chromatin
L	0046982	molecular_function	protein heterodimerization activity
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0030527	molecular_function	structural constituent of chromatin
M	0046982	molecular_function	protein heterodimerization activity
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0030527	molecular_function	structural constituent of chromatin
N	0046982	molecular_function	protein heterodimerization activity
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005694	cellular_component	chromosome
P	0006334	biological_process	nucleosome assembly
P	0030527	molecular_function	structural constituent of chromatin
P	0046982	molecular_function	protein heterodimerization activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005694	cellular_component	chromosome
R	0030527	molecular_function	structural constituent of chromatin
R	0046982	molecular_function	protein heterodimerization activity
V	0000182	molecular_function	rDNA binding
V	0000976	molecular_function	transcription cis-regulatory region binding
V	0001178	biological_process	regulation of transcriptional start site selection at RNA polymerase II promoter
V	0003677	molecular_function	DNA binding
V	0003730	molecular_function	mRNA 3'-UTR binding
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0006325	biological_process	chromatin organization
V	0006338	biological_process	chromatin remodeling
V	0006354	biological_process	DNA-templated transcription elongation
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006363	biological_process	termination of RNA polymerase I transcription
V	0006369	biological_process	termination of RNA polymerase II transcription
V	0007062	biological_process	sister chromatid cohesion
V	0008094	molecular_function	ATP-dependent activity, acting on DNA
V	0009408	biological_process	response to heat
V	0016587	cellular_component	Isw1 complex
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0030874	cellular_component	nucleolar chromatin
V	0031491	molecular_function	nucleosome binding
V	0036436	cellular_component	Isw1a complex
V	0036437	cellular_component	Isw1b complex
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0046832	biological_process	negative regulation of RNA export from nucleus
V	0140658	molecular_function	ATP-dependent chromatin remodeler activity
V	1902275	biological_process	regulation of chromatin organization
V	1903895	biological_process	negative regulation of IRE1-mediated unfolded protein response

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Citrulline; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	ARG2
N	LYS9
N	LYS12
N	LYS17
R	LYS2
R	LYS9
R	LYS12
R	LYS17
A	ARG17
E	ARG2
E	ARG17
K	ARG2
K	ARG17
O	ARG2
O	ARG17
N	LYS2

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR3
E	THR3
K	THR3
O	THR3

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12138181

Chain	Residue	Details
A	LYS4
E	LYS4
K	LYS4
O	LYS4
M	LYS9
M	LYS95
Q	LYS9
Q	LYS95

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	GLN5
E	GLN5
K	GLN5
O	GLN5
N	LYS117
R	LYS117

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR6
L	LYS16
L	LYS44
L	LYS79
P	LYS8
P	LYS16
P	LYS44
P	LYS79
A	THR11
E	THR6
E	THR11
K	THR6
K	THR11
O	THR6
O	THR11
L	LYS8

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250

Chain	Residue	Details
A	ARG8
E	ARG8
K	ARG8
O	ARG8
L	LYS12
L	LYS20
P	LYS12
P	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:12138181

Chain	Residue	Details
A	LYS9
E	LYS9
K	LYS9
O	LYS9
L	LYS31
L	LYS91
P	LYS31
P	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER10
M	LYS15
M	LYS119
Q	LYS13
Q	LYS15
Q	LYS119
E	SER10
K	SER10
O	SER10
G	LYS13
G	LYS15
G	LYS119
M	LYS13

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
A	LYS14
E	LYS14
K	LYS14
O	LYS14
L	TYR51
L	TYR88
P	TYR51
P	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS18
E	LYS64
K	LYS18
K	LYS23
K	LYS27
K	LYS36
K	LYS64
O	LYS18
O	LYS23
O	LYS27
O	LYS36
A	LYS23
O	LYS64
A	LYS27
A	LYS36
A	LYS64
E	LYS18
E	LYS23
E	LYS27
E	LYS36

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Citrulline => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	ARG26
E	ARG26
K	ARG26
O	ARG26

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER28
E	SER28
K	SER28
O	SER28

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
A	LYS37
E	LYS37
K	LYS37
O	LYS37
L	LYS91
P	LYS91

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	TYR41
E	TYR41
K	TYR41
O	TYR41

---

site_id	SWS_FT_FI15
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
A	LYS56
A	LYS79
E	LYS56
E	LYS79
K	LYS56
K	LYS79
O	LYS56
O	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER57
E	SER57
K	SER57
O	SER57

---

site_id	SWS_FT_FI17
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR80
A	THR107
E	THR80
E	THR107
K	THR80
K	THR107
O	THR80
O	THR107

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
A	SER86
E	SER86
K	SER86
O	SER86

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS115
E	LYS115
K	LYS115
O	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS122
E	LYS122
K	LYS122
O	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	CYS110
E	CYS110
K	CYS110
O	CYS110

---