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7X2U

Structure of a human NHE3-CHP1 complex in the autoinhibited state

Functional Information from GO Data
ChainGOidnamespacecontents
A0006812biological_processmonoatomic cation transport
A0006814biological_processsodium ion transport
A0006885biological_processregulation of pH
A0015297molecular_functionantiporter activity
A0015385molecular_functionsodium:proton antiporter activity
A0016020cellular_componentmembrane
A0055085biological_processtransmembrane transport
A1902600biological_processproton transmembrane transport
B0006812biological_processmonoatomic cation transport
B0006814biological_processsodium ion transport
B0006885biological_processregulation of pH
B0015297molecular_functionantiporter activity
B0015385molecular_functionsodium:proton antiporter activity
B0016020cellular_componentmembrane
B0055085biological_processtransmembrane transport
B1902600biological_processproton transmembrane transport
C0000139cellular_componentGolgi membrane
C0001578biological_processmicrotubule bundle formation
C0001933biological_processnegative regulation of protein phosphorylation
C0004860molecular_functionprotein kinase inhibitor activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0006813biological_processpotassium ion transport
C0007264biological_processsmall GTPase-mediated signal transduction
C0008017molecular_functionmicrotubule binding
C0010923biological_processnegative regulation of phosphatase activity
C0012505cellular_componentendomembrane system
C0015031biological_processprotein transport
C0015385molecular_functionsodium:proton antiporter activity
C0015459molecular_functionpotassium channel regulator activity
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0019900molecular_functionkinase binding
C0022406biological_processmembrane docking
C0030133cellular_componenttransport vesicle
C0031122biological_processcytoplasmic microtubule organization
C0031397biological_processnegative regulation of protein ubiquitination
C0031953biological_processnegative regulation of protein autophosphorylation
C0032088biological_processnegative regulation of NF-kappaB transcription factor activity
C0032417biological_processpositive regulation of sodium:proton antiporter activity
C0035725biological_processsodium ion transmembrane transport
C0042306biological_processregulation of protein import into nucleus
C0042308biological_processnegative regulation of protein import into nucleus
C0045121cellular_componentmembrane raft
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050821biological_processprotein stabilization
C0051222biological_processpositive regulation of protein transport
C0051453biological_processregulation of intracellular pH
C0060050biological_processpositive regulation of protein glycosylation
C0061024biological_processmembrane organization
C0061025biological_processmembrane fusion
C0070062cellular_componentextracellular exosome
C0070884biological_processregulation of calcineurin-NFAT signaling cascade
C0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
C0071073biological_processpositive regulation of phospholipid biosynthetic process
C0071468biological_processcellular response to acidic pH
C0090314biological_processpositive regulation of protein targeting to membrane
C1990351cellular_componenttransporter complex
D0000139cellular_componentGolgi membrane
D0001578biological_processmicrotubule bundle formation
D0001933biological_processnegative regulation of protein phosphorylation
D0004860molecular_functionprotein kinase inhibitor activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006469biological_processnegative regulation of protein kinase activity
D0006611biological_processprotein export from nucleus
D0006813biological_processpotassium ion transport
D0007264biological_processsmall GTPase-mediated signal transduction
D0008017molecular_functionmicrotubule binding
D0010923biological_processnegative regulation of phosphatase activity
D0012505cellular_componentendomembrane system
D0015031biological_processprotein transport
D0015385molecular_functionsodium:proton antiporter activity
D0015459molecular_functionpotassium channel regulator activity
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0019900molecular_functionkinase binding
D0022406biological_processmembrane docking
D0030133cellular_componenttransport vesicle
D0031122biological_processcytoplasmic microtubule organization
D0031397biological_processnegative regulation of protein ubiquitination
D0031953biological_processnegative regulation of protein autophosphorylation
D0032088biological_processnegative regulation of NF-kappaB transcription factor activity
D0032417biological_processpositive regulation of sodium:proton antiporter activity
D0035725biological_processsodium ion transmembrane transport
D0042306biological_processregulation of protein import into nucleus
D0042308biological_processnegative regulation of protein import into nucleus
D0045121cellular_componentmembrane raft
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050821biological_processprotein stabilization
D0051222biological_processpositive regulation of protein transport
D0051453biological_processregulation of intracellular pH
D0060050biological_processpositive regulation of protein glycosylation
D0061024biological_processmembrane organization
D0061025biological_processmembrane fusion
D0070062cellular_componentextracellular exosome
D0070884biological_processregulation of calcineurin-NFAT signaling cascade
D0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
D0071073biological_processpositive regulation of phospholipid biosynthetic process
D0071468biological_processcellular response to acidic pH
D0090314biological_processpositive regulation of protein targeting to membrane
D1990351cellular_componenttransporter complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LGISavNpFIWTWNT
ChainResidueDetails
ALEU354-THR368

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
CASP123
DASP123
DASP125
DASP127
DLYS129
DGLU134
DASP164
DASP166
DASP168
DGLU175
CASP125
CASP127
CLYS129
CGLU134
CASP164
CASP166
CASP168
CGLU175

site_idSWS_FT_FI2
Number of Residues58
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
ASER75-VAL82
BLYS280-HIS281
BLYS324-GLN330
BTHR390-GLU402
APHE130-PRO132
AHIS204-VAL205
ALYS280-HIS281
ALYS324-GLN330
ATHR390-GLU402
BSER75-VAL82
BPHE130-PRO132
BHIS204-VAL205

site_idSWS_FT_FI3
Number of Residues38
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
APRO83-ALA102
BPRO83-ALA102

site_idSWS_FT_FI4
Number of Residues80
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AASP103-THR111
BSER305-LEU306
BASN360-ASN367
BASP427-GLU433
AGLY169-PHE181
AGLY238-GLY244
ASER305-LEU306
AASN360-ASN367
AASP427-GLU433
BASP103-THR111
BGLY169-PHE181
BGLY238-GLY244

site_idSWS_FT_FI5
Number of Residues34
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
APRO112-TYR129
BPRO112-TYR129

site_idSWS_FT_FI6
Number of Residues70
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
AASN133-SER168
BASN133-SER168

site_idSWS_FT_FI7
Number of Residues42
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
ALEU182-VAL203
BLEU182-VAL203

site_idSWS_FT_FI8
Number of Residues62
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
AASN206-LEU237
BASN206-LEU237

site_idSWS_FT_FI9
Number of Residues68
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
AVAL245-THR279
BVAL245-THR279

site_idSWS_FT_FI10
Number of Residues44
DetailsTRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
AVAL282-LEU304
BVAL282-LEU304

site_idSWS_FT_FI11
Number of Residues32
DetailsTRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
ASER307-VAL323
BSER307-VAL323

site_idSWS_FT_FI12
Number of Residues56
DetailsTRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
ASER331-VAL359
BSER331-VAL359

site_idSWS_FT_FI13
Number of Residues42
DetailsTRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
ATHR368-GLN389
BTHR368-GLN389

site_idSWS_FT_FI14
Number of Residues46
DetailsTRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
APRO403-LEU426
BPRO403-LEU426

site_idSWS_FT_FI15
Number of Residues66
DetailsTRANSMEM: Helical; Name=13 => ECO:0000269|PubMed:35613257, ECO:0000312|PDB:7X2U
ChainResidueDetails
ALYS434-ARG467
BLYS434-ARG467

site_idSWS_FT_FI16
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:35613257, ECO:0007744|PDB:7X2U
ChainResidueDetails
AGLY138
BTHR142
BMET398
BGLN497
BILE498
BHIS500
AGLY141
ATHR142
AMET398
AGLN497
AILE498
AHIS500
BGLY138
BGLY141

site_idSWS_FT_FI17
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P26433
ChainResidueDetails
ASER555
ASER563
ASER607
BSER555
BSER563
BSER607

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:G3X939
ChainResidueDetails
ASER592
BSER592

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Phosphoserine; by SGK1 => ECO:0000250|UniProtKB:P26432
ChainResidueDetails
ASER663
BSER663

site_idSWS_FT_FI20
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN241
BASN241

237992

PDB entries from 2025-06-25

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