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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7WV3

Toll-like receptor3 linear cluster

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0001774biological_processmicroglial cell activation
A0002224biological_processtoll-like receptor signaling pathway
A0002376biological_processimmune system process
A0002684biological_processpositive regulation of immune system process
A0002730biological_processregulation of dendritic cell cytokine production
A0003723molecular_functionRNA binding
A0003725molecular_functiondouble-stranded RNA binding
A0004888molecular_functiontransmembrane signaling receptor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006952biological_processdefense response
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006972biological_processhyperosmotic response
A0007165biological_processsignal transduction
A0007250biological_processactivation of NF-kappaB-inducing kinase activity
A0007254biological_processJNK cascade
A0008584biological_processmale gonad development
A0009597biological_processdetection of virus
A0009615biological_processresponse to virus
A0009986cellular_componentcell surface
A0010008cellular_componentendosome membrane
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0032481biological_processpositive regulation of type I interferon production
A0032722biological_processpositive regulation of chemokine production
A0032727biological_processpositive regulation of interferon-alpha production
A0032728biological_processpositive regulation of interferon-beta production
A0032729biological_processpositive regulation of type II interferon production
A0032735biological_processpositive regulation of interleukin-12 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0034138biological_processtoll-like receptor 3 signaling pathway
A0034139biological_processregulation of toll-like receptor 3 signaling pathway
A0034343biological_processtype III interferon production
A0034346biological_processpositive regulation of type III interferon production
A0035458biological_processcellular response to interferon-beta
A0036020cellular_componentendolysosome membrane
A0038023molecular_functionsignaling receptor activity
A0038187molecular_functionpattern recognition receptor activity
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043330biological_processresponse to exogenous dsRNA
A0043331biological_processresponse to dsRNA
A0044389molecular_functionubiquitin-like protein ligase binding
A0045087biological_processinnate immune response
A0045671biological_processnegative regulation of osteoclast differentiation
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046330biological_processpositive regulation of JNK cascade
A0050729biological_processpositive regulation of inflammatory response
A0051607biological_processdefense response to virus
A0060907biological_processpositive regulation of macrophage cytokine production
A0071260biological_processcellular response to mechanical stimulus
A0071346biological_processcellular response to type II interferon
A0071360biological_processcellular response to exogenous dsRNA
A0071466biological_processcellular response to xenobiotic stimulus
A0090594biological_processinflammatory response to wounding
A0097191biological_processextrinsic apoptotic signaling pathway
A0097527biological_processnecroptotic signaling pathway
A0098586biological_processcellular response to virus
A0141124biological_processintracellular signaling cassette
A1900017biological_processpositive regulation of cytokine production involved in inflammatory response
B0000139cellular_componentGolgi membrane
B0000165biological_processMAPK cascade
B0001774biological_processmicroglial cell activation
B0002224biological_processtoll-like receptor signaling pathway
B0002376biological_processimmune system process
B0002684biological_processpositive regulation of immune system process
B0002730biological_processregulation of dendritic cell cytokine production
B0003723molecular_functionRNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0004888molecular_functiontransmembrane signaling receptor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006952biological_processdefense response
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0006972biological_processhyperosmotic response
B0007165biological_processsignal transduction
B0007250biological_processactivation of NF-kappaB-inducing kinase activity
B0007254biological_processJNK cascade
B0008584biological_processmale gonad development
B0009597biological_processdetection of virus
B0009615biological_processresponse to virus
B0009986cellular_componentcell surface
B0010008cellular_componentendosome membrane
B0010628biological_processpositive regulation of gene expression
B0016020cellular_componentmembrane
B0032481biological_processpositive regulation of type I interferon production
B0032722biological_processpositive regulation of chemokine production
B0032727biological_processpositive regulation of interferon-alpha production
B0032728biological_processpositive regulation of interferon-beta production
B0032729biological_processpositive regulation of type II interferon production
B0032735biological_processpositive regulation of interleukin-12 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032757biological_processpositive regulation of interleukin-8 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0034138biological_processtoll-like receptor 3 signaling pathway
B0034139biological_processregulation of toll-like receptor 3 signaling pathway
B0034343biological_processtype III interferon production
B0034346biological_processpositive regulation of type III interferon production
B0035458biological_processcellular response to interferon-beta
B0036020cellular_componentendolysosome membrane
B0038023molecular_functionsignaling receptor activity
B0038187molecular_functionpattern recognition receptor activity
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043330biological_processresponse to exogenous dsRNA
B0043331biological_processresponse to dsRNA
B0044389molecular_functionubiquitin-like protein ligase binding
B0045087biological_processinnate immune response
B0045671biological_processnegative regulation of osteoclast differentiation
B0045766biological_processpositive regulation of angiogenesis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046330biological_processpositive regulation of JNK cascade
B0050729biological_processpositive regulation of inflammatory response
B0051607biological_processdefense response to virus
B0060907biological_processpositive regulation of macrophage cytokine production
B0071260biological_processcellular response to mechanical stimulus
B0071346biological_processcellular response to type II interferon
B0071360biological_processcellular response to exogenous dsRNA
B0071466biological_processcellular response to xenobiotic stimulus
B0090594biological_processinflammatory response to wounding
B0097191biological_processextrinsic apoptotic signaling pathway
B0097527biological_processnecroptotic signaling pathway
B0098586biological_processcellular response to virus
B0141124biological_processintracellular signaling cassette
B1900017biological_processpositive regulation of cytokine production involved in inflammatory response
C0000139cellular_componentGolgi membrane
C0000165biological_processMAPK cascade
C0001774biological_processmicroglial cell activation
C0002224biological_processtoll-like receptor signaling pathway
C0002376biological_processimmune system process
C0002684biological_processpositive regulation of immune system process
C0002730biological_processregulation of dendritic cell cytokine production
C0003723molecular_functionRNA binding
C0003725molecular_functiondouble-stranded RNA binding
C0004888molecular_functiontransmembrane signaling receptor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006952biological_processdefense response
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0006972biological_processhyperosmotic response
C0007165biological_processsignal transduction
C0007250biological_processactivation of NF-kappaB-inducing kinase activity
C0007254biological_processJNK cascade
C0008584biological_processmale gonad development
C0009597biological_processdetection of virus
C0009615biological_processresponse to virus
C0009986cellular_componentcell surface
C0010008cellular_componentendosome membrane
C0010628biological_processpositive regulation of gene expression
C0016020cellular_componentmembrane
C0032481biological_processpositive regulation of type I interferon production
C0032722biological_processpositive regulation of chemokine production
C0032727biological_processpositive regulation of interferon-alpha production
C0032728biological_processpositive regulation of interferon-beta production
C0032729biological_processpositive regulation of type II interferon production
C0032735biological_processpositive regulation of interleukin-12 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034138biological_processtoll-like receptor 3 signaling pathway
C0034139biological_processregulation of toll-like receptor 3 signaling pathway
C0034343biological_processtype III interferon production
C0034346biological_processpositive regulation of type III interferon production
C0035458biological_processcellular response to interferon-beta
C0036020cellular_componentendolysosome membrane
C0038023molecular_functionsignaling receptor activity
C0038187molecular_functionpattern recognition receptor activity
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043330biological_processresponse to exogenous dsRNA
C0043331biological_processresponse to dsRNA
C0044389molecular_functionubiquitin-like protein ligase binding
C0045087biological_processinnate immune response
C0045671biological_processnegative regulation of osteoclast differentiation
C0045766biological_processpositive regulation of angiogenesis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046330biological_processpositive regulation of JNK cascade
C0050729biological_processpositive regulation of inflammatory response
C0051607biological_processdefense response to virus
C0060907biological_processpositive regulation of macrophage cytokine production
C0071260biological_processcellular response to mechanical stimulus
C0071346biological_processcellular response to type II interferon
C0071360biological_processcellular response to exogenous dsRNA
C0071466biological_processcellular response to xenobiotic stimulus
C0090594biological_processinflammatory response to wounding
C0097191biological_processextrinsic apoptotic signaling pathway
C0097527biological_processnecroptotic signaling pathway
C0098586biological_processcellular response to virus
C0141124biological_processintracellular signaling cassette
C1900017biological_processpositive regulation of cytokine production involved in inflammatory response
D0000139cellular_componentGolgi membrane
D0000165biological_processMAPK cascade
D0001774biological_processmicroglial cell activation
D0002224biological_processtoll-like receptor signaling pathway
D0002376biological_processimmune system process
D0002684biological_processpositive regulation of immune system process
D0002730biological_processregulation of dendritic cell cytokine production
D0003723molecular_functionRNA binding
D0003725molecular_functiondouble-stranded RNA binding
D0004888molecular_functiontransmembrane signaling receptor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006952biological_processdefense response
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0006972biological_processhyperosmotic response
D0007165biological_processsignal transduction
D0007250biological_processactivation of NF-kappaB-inducing kinase activity
D0007254biological_processJNK cascade
D0008584biological_processmale gonad development
D0009597biological_processdetection of virus
D0009615biological_processresponse to virus
D0009986cellular_componentcell surface
D0010008cellular_componentendosome membrane
D0010628biological_processpositive regulation of gene expression
D0016020cellular_componentmembrane
D0032481biological_processpositive regulation of type I interferon production
D0032722biological_processpositive regulation of chemokine production
D0032727biological_processpositive regulation of interferon-alpha production
D0032728biological_processpositive regulation of interferon-beta production
D0032729biological_processpositive regulation of type II interferon production
D0032735biological_processpositive regulation of interleukin-12 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032757biological_processpositive regulation of interleukin-8 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034138biological_processtoll-like receptor 3 signaling pathway
D0034139biological_processregulation of toll-like receptor 3 signaling pathway
D0034343biological_processtype III interferon production
D0034346biological_processpositive regulation of type III interferon production
D0035458biological_processcellular response to interferon-beta
D0036020cellular_componentendolysosome membrane
D0038023molecular_functionsignaling receptor activity
D0038187molecular_functionpattern recognition receptor activity
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043330biological_processresponse to exogenous dsRNA
D0043331biological_processresponse to dsRNA
D0044389molecular_functionubiquitin-like protein ligase binding
D0045087biological_processinnate immune response
D0045671biological_processnegative regulation of osteoclast differentiation
D0045766biological_processpositive regulation of angiogenesis
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046330biological_processpositive regulation of JNK cascade
D0050729biological_processpositive regulation of inflammatory response
D0051607biological_processdefense response to virus
D0060907biological_processpositive regulation of macrophage cytokine production
D0071260biological_processcellular response to mechanical stimulus
D0071346biological_processcellular response to type II interferon
D0071360biological_processcellular response to exogenous dsRNA
D0071466biological_processcellular response to xenobiotic stimulus
D0090594biological_processinflammatory response to wounding
D0097191biological_processextrinsic apoptotic signaling pathway
D0097527biological_processnecroptotic signaling pathway
D0098586biological_processcellular response to virus
D0141124biological_processintracellular signaling cassette
D1900017biological_processpositive regulation of cytokine production involved in inflammatory response
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues84
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues84
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues84
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues84
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues88
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues84
DetailsRepeat: {"description":"LRR 9"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues84
DetailsRepeat: {"description":"LRR 10"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues84
DetailsRepeat: {"description":"LRR 11"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues84
DetailsRepeat: {"description":"LRR 12"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues84
DetailsRepeat: {"description":"LRR 13"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues80
DetailsRepeat: {"description":"LRR 14"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues84
DetailsRepeat: {"description":"LRR 15"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues88
DetailsRepeat: {"description":"LRR 16"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues84
DetailsRepeat: {"description":"LRR 17"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues84
DetailsRepeat: {"description":"LRR 18"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues84
DetailsRepeat: {"description":"LRR 19"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues84
DetailsRepeat: {"description":"LRR 20"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues84
DetailsRepeat: {"description":"LRR 21"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues84
DetailsRepeat: {"description":"LRR 22"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16043704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22579623","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16043704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22579623","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15961631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22579623","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16043704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22579623","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues24
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15961631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16043704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22579623","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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