7WLJ
CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005891 | cellular_component | voltage-gated calcium channel complex |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019228 | biological_process | neuronal action potential |
| A | 0030431 | biological_process | sleep |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1252 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ASN78 | |
| A | GLU1432-THR1485 | |
| A | ARG1544-LEU1556 | |
| A | LEU1608-ASN1621 | |
| A | LYS1731-ARG2223 | |
| A | LYS142-ASP148 | |
| A | VAL192-ASN211 | |
| A | THR399-LYS640 | |
| A | ASP698-ASN702 | |
| A | VAL754-THR764 | |
| A | GLU863-ILE1166 | |
| A | GLY1231-ASP1244 | |
| A | VAL1295-LYS1304 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO79-TYR99 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 441 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN100-ASP120 | |
| A | GLU1507-CYS1522 | |
| A | PRO1578-ILE1583 | |
| A | LYS1643-TYR1709 | |
| A | LEU169-ASN173 | |
| A | GLY233-TYR377 | |
| A | HIS662-ASN676 | |
| A | GLN722-VAL729 | |
| A | CYS786-TYR841 | |
| A | ALA1188-TYR1209 | |
| A | LYS1266-ARG1272 | |
| A | GLN1326-TYR1410 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE121-GLY141 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | THR149-ASP168 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU174-ARG191 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL212-ALA232 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE378-ALA398 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR641-HIS661 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL677-PHE697 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO703-GLY721 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU730-VAL753 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE765-GLY785 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE842-VAL862 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1167-ILE1187 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1210-PHE1230 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY1245-ALA1265 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL1273-LEU1294 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO1305-VAL1325 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE1411-VAL1431 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | SER1486-LEU1506 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN1523-LEU1543 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA1557-LEU1577 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1584-ALA1607 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU1622-GLY1642 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE1710-MET1730 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 4 |
| Details | SITE: Calcium ion selectivity and permeability => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU357 | |
| A | GLU821 | |
| A | ASP1380 | |
| A | ASP1678 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0Y8 |
| Chain | Residue | Details |
| A | SER1058 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN173 | |
| A | ASN244 | |
| A | ASN311 | |
| A | ASN1342 | |
| A | ASN1345 |
