7WIW
Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0010106 | biological_process | cellular response to iron ion starvation |
| A | 0015343 | molecular_function | siderophore-iron transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0033214 | biological_process | siderophore-iron import into cell |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0044847 | biological_process | iron acquisition from host |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071949 | molecular_function | FAD binding |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0010106 | biological_process | cellular response to iron ion starvation |
| B | 0015343 | molecular_function | siderophore-iron transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0033214 | biological_process | siderophore-iron import into cell |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0044847 | biological_process | iron acquisition from host |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0140359 | molecular_function | ABC-type transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERQRLTIARAI |
| Chain | Residue | Details |
| A | LEU746-ILE760 | |
| B | LEU470-LEU484 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 113 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 564 |
| Details | Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 468 |
| Details | Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 29 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"19948799","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 117 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"19948799","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
