Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7W3O

Crystal structure of human CYB5R3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005811	cellular_component	lipid droplet
A	0005833	cellular_component	hemoglobin complex
A	0006695	biological_process	cholesterol biosynthetic process
A	0006809	biological_process	nitric oxide biosynthetic process
A	0008015	biological_process	blood circulation
A	0016020	cellular_component	membrane
A	0016208	molecular_function	AMP binding
A	0016491	molecular_function	oxidoreductase activity
A	0031966	cellular_component	mitochondrial membrane
A	0035578	cellular_component	azurophil granule lumen
A	0043531	molecular_function	ADP binding
A	0050421	molecular_function	nitrite reductase (NO-forming) activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0051287	molecular_function	NAD binding
A	0071949	molecular_function	FAD binding
A	1903958	cellular_component	nitric-oxide synthase complex
B	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005811	cellular_component	lipid droplet
B	0005833	cellular_component	hemoglobin complex
B	0006695	biological_process	cholesterol biosynthetic process
B	0006809	biological_process	nitric oxide biosynthetic process
B	0008015	biological_process	blood circulation
B	0016020	cellular_component	membrane
B	0016208	molecular_function	AMP binding
B	0016491	molecular_function	oxidoreductase activity
B	0031966	cellular_component	mitochondrial membrane
B	0035578	cellular_component	azurophil granule lumen
B	0043531	molecular_function	ADP binding
B	0050421	molecular_function	nitrite reductase (NO-forming) activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0051287	molecular_function	NAD binding
B	0071949	molecular_function	FAD binding
B	1903958	cellular_component	nitric-oxide synthase complex
C	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005811	cellular_component	lipid droplet
C	0005833	cellular_component	hemoglobin complex
C	0006695	biological_process	cholesterol biosynthetic process
C	0006809	biological_process	nitric oxide biosynthetic process
C	0008015	biological_process	blood circulation
C	0016020	cellular_component	membrane
C	0016208	molecular_function	AMP binding
C	0016491	molecular_function	oxidoreductase activity
C	0031966	cellular_component	mitochondrial membrane
C	0035578	cellular_component	azurophil granule lumen
C	0043531	molecular_function	ADP binding
C	0050421	molecular_function	nitrite reductase (NO-forming) activity
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0051287	molecular_function	NAD binding
C	0071949	molecular_function	FAD binding
C	1903958	cellular_component	nitric-oxide synthase complex
D	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005811	cellular_component	lipid droplet
D	0005833	cellular_component	hemoglobin complex
D	0006695	biological_process	cholesterol biosynthetic process
D	0006809	biological_process	nitric oxide biosynthetic process
D	0008015	biological_process	blood circulation
D	0016020	cellular_component	membrane
D	0016208	molecular_function	AMP binding
D	0016491	molecular_function	oxidoreductase activity
D	0031966	cellular_component	mitochondrial membrane
D	0035578	cellular_component	azurophil granule lumen
D	0043531	molecular_function	ADP binding
D	0050421	molecular_function	nitrite reductase (NO-forming) activity
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0051287	molecular_function	NAD binding
D	0071949	molecular_function	FAD binding
D	1903958	cellular_component	nitric-oxide synthase complex
E	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005811	cellular_component	lipid droplet
E	0005833	cellular_component	hemoglobin complex
E	0006695	biological_process	cholesterol biosynthetic process
E	0006809	biological_process	nitric oxide biosynthetic process
E	0008015	biological_process	blood circulation
E	0016020	cellular_component	membrane
E	0016208	molecular_function	AMP binding
E	0016491	molecular_function	oxidoreductase activity
E	0031966	cellular_component	mitochondrial membrane
E	0035578	cellular_component	azurophil granule lumen
E	0043531	molecular_function	ADP binding
E	0050421	molecular_function	nitrite reductase (NO-forming) activity
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0051287	molecular_function	NAD binding
E	0071949	molecular_function	FAD binding
E	1903958	cellular_component	nitric-oxide synthase complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	BINDING: BINDING => ECO:0000269\|PubMed:15502298, ECO:0007744\|PDB:1UMK

Chain	Residue	Details
A	ARG66
A	THR159
B	ARG66
B	PRO67
B	TYR68
B	VAL83
B	LYS85
B	PHE88
B	LYS100
B	MET101
B	SER102
A	PRO67
B	THR159
C	ARG66
C	PRO67
C	TYR68
C	VAL83
C	LYS85
C	PHE88
C	LYS100
C	MET101
C	SER102
A	TYR68
C	THR159
D	ARG66
D	PRO67
D	TYR68
D	VAL83
D	LYS85
D	PHE88
D	LYS100
D	MET101
D	SER102
A	VAL83
D	THR159
E	ARG66
E	PRO67
E	TYR68
E	VAL83
E	LYS85
E	PHE88
E	LYS100
E	MET101
E	SER102
A	LYS85
E	THR159
A	PHE88
A	LYS100
A	MET101
A	SER102

site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS16
B	LYS16
C	LYS16
D	LYS16
E	LYS16

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	TYR17
B	TYR17
C	TYR17
D	TYR17
E	TYR17

site_id	SWS_FT_FI4
Number of Residues	5
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9DCN2

Chain	Residue	Details
A	LYS94
B	LYS94
C	LYS94
D	LYS94
E	LYS94

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)