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7W0N

Cryo-EM structure of a dimeric GPCR-Gi complex with peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0010854molecular_functionadenylate cyclase regulator activity
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0034695biological_processresponse to prostaglandin E
A0043434biological_processresponse to peptide hormone
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0072678biological_processT cell migration
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
D0001525biological_processangiogenesis
D0001570biological_processvasculogenesis
D0005179molecular_functionhormone activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0007369biological_processgastrulation
D0007492biological_processendoderm development
D0007507biological_processheart development
D0007509biological_processmesoderm migration involved in gastrulation
D0007512biological_processadult heart development
D0030154biological_processcell differentiation
D0031704molecular_functionapelin receptor binding
D0035050biological_processembryonic heart tube development
D0045766biological_processpositive regulation of angiogenesis
D0045823biological_processpositive regulation of heart contraction
D0060183biological_processapelin receptor signaling pathway
D0060674biological_processplacenta blood vessel development
D0060976biological_processcoronary vasculature development
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0090133biological_processmesendoderm migration
D0090134biological_processcell migration involved in mesendoderm migration
D1901165biological_processpositive regulation of trophoblast cell migration
D1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
D1904022biological_processpositive regulation of G protein-coupled receptor internalization
E0001525biological_processangiogenesis
E0001570biological_processvasculogenesis
E0005179molecular_functionhormone activity
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0007369biological_processgastrulation
E0007492biological_processendoderm development
E0007507biological_processheart development
E0007509biological_processmesoderm migration involved in gastrulation
E0007512biological_processadult heart development
E0030154biological_processcell differentiation
E0031704molecular_functionapelin receptor binding
E0035050biological_processembryonic heart tube development
E0045766biological_processpositive regulation of angiogenesis
E0045823biological_processpositive regulation of heart contraction
E0060183biological_processapelin receptor signaling pathway
E0060674biological_processplacenta blood vessel development
E0060976biological_processcoronary vasculature development
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0090133biological_processmesendoderm migration
E0090134biological_processcell migration involved in mesendoderm migration
E1901165biological_processpositive regulation of trophoblast cell migration
E1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
E1904022biological_processpositive regulation of G protein-coupled receptor internalization
Q0004930molecular_functionG protein-coupled receptor activity
Q0005506molecular_functioniron ion binding
Q0007186biological_processG protein-coupled receptor signaling pathway
Q0009055molecular_functionelectron transfer activity
Q0016020cellular_componentmembrane
Q0020037molecular_functionheme binding
Q0022900biological_processelectron transport chain
Q0042597cellular_componentperiplasmic space
Q0046872molecular_functionmetal ion binding
R0004930molecular_functionG protein-coupled receptor activity
R0005506molecular_functioniron ion binding
R0007186biological_processG protein-coupled receptor signaling pathway
R0009055molecular_functionelectron transfer activity
R0016020cellular_componentmembrane
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0042597cellular_componentperiplasmic space
R0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfCLTGLSFDRYLaI
ChainResidueDetails
QALA115-ILE131

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN5
EASN5
RTRP-98
RILE-3

site_idSWS_FT_FI2
Number of Residues48
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
QSER27-TRP51
RSER27-TRP51

site_idSWS_FT_FI3
Number of Residues108
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
QTHR52-ILE66
QASP126-VAL144
QPHE222-ARG244
RTHR52-ILE66
RASP126-VAL144
RPHE222-ARG244

site_idSWS_FT_FI4
Number of Residues48
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
QPHE67-ARG91
RPHE67-ARG91

site_idSWS_FT_FI5
Number of Residues106
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
QASP92-PHE100
QLEU167-GLY200
QMET272-ASP284
RASP92-PHE100
RLEU167-GLY200
RMET272-ASP284

site_idSWS_FT_FI6
Number of Residues48
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
QPHE101-PHE125
RPHE101-PHE125

site_idSWS_FT_FI7
Number of Residues42
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
QSER145-VAL166
RSER145-VAL166

site_idSWS_FT_FI8
Number of Residues40
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
QLEU201-TYR221
RLEU201-TYR221

site_idSWS_FT_FI9
Number of Residues52
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
QARG245-TYR271
RARG245-TYR271

site_idSWS_FT_FI10
Number of Residues46
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
QLEU285-LEU308
RLEU285-LEU308

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
QASN15
QASN175
RASN15
RASN175

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PDB entries from 2024-11-06

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