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7W0D

Dicer2-LoqsPD-dsRNA complex at mid-translocation state

Functional Information from GO Data
ChainGOidnamespacecontents
A0002230biological_processpositive regulation of defense response to virus by host
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003730molecular_functionmRNA 3'-UTR binding
A0004525molecular_functionribonuclease III activity
A0004530molecular_functiondeoxyribonuclease I activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006309biological_processapoptotic DNA fragmentation
A0006396biological_processRNA processing
A0007626biological_processlocomotory behavior
A0008186molecular_functionATP-dependent activity, acting on RNA
A0009047biological_processdosage compensation by hyperactivation of X chromosome
A0009597biological_processdetection of virus
A0009616biological_processRNAi-mediated antiviral immune response
A0016442cellular_componentRISC complex
A0016887molecular_functionATP hydrolysis activity
A0016891molecular_functionRNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
A0030422biological_processsiRNA processing
A0031054biological_processpre-miRNA processing
A0031507biological_processheterochromatin formation
A0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
A0035197molecular_functionsiRNA binding
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0045089biological_processpositive regulation of innate immune response
A0045752biological_processpositive regulation of Toll signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0051607biological_processdefense response to virus
A0070578cellular_componentRISC-loading complex
A0070922biological_processRISC complex assembly
A0098586biological_processcellular response to virus
A0098795biological_processglobal gene silencing by mRNA cleavage
A0110064biological_processlncRNA catabolic process
F0002230biological_processpositive regulation of defense response to virus by host
F0003676molecular_functionnucleic acid binding
F0003723molecular_functionRNA binding
F0003730molecular_functionmRNA 3'-UTR binding
F0004525molecular_functionribonuclease III activity
F0004530molecular_functiondeoxyribonuclease I activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0006309biological_processapoptotic DNA fragmentation
F0006396biological_processRNA processing
F0007626biological_processlocomotory behavior
F0008186molecular_functionATP-dependent activity, acting on RNA
F0009047biological_processdosage compensation by hyperactivation of X chromosome
F0009597biological_processdetection of virus
F0009616biological_processRNAi-mediated antiviral immune response
F0016442cellular_componentRISC complex
F0016887molecular_functionATP hydrolysis activity
F0016891molecular_functionRNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
F0030422biological_processsiRNA processing
F0031054biological_processpre-miRNA processing
F0031507biological_processheterochromatin formation
F0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
F0035197molecular_functionsiRNA binding
F0036464cellular_componentcytoplasmic ribonucleoprotein granule
F0045089biological_processpositive regulation of innate immune response
F0045752biological_processpositive regulation of Toll signaling pathway
F0048471cellular_componentperinuclear region of cytoplasm
F0051607biological_processdefense response to virus
F0070578cellular_componentRISC-loading complex
F0070922biological_processRISC complex assembly
F0098586biological_processcellular response to virus
F0098795biological_processglobal gene silencing by mRNA cleavage
F0110064biological_processlncRNA catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues356
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues340
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues102
DetailsDomain: {"description":"Dicer dsRNA-binding fold","evidences":[{"source":"PROSITE-ProRule","id":"PRU00657","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues54
DetailsDomain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues205
DetailsDomain: {"description":"RNase III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00177","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues22
DetailsDomain: {"description":"DRBM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00266","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues234
DetailsRegion: {"description":"Helicase insertion domain; involved in homodimerization","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues24
DetailsRegion: {"description":"Sufficient for interaction with loqs isoform PD (loqs-PD)","evidences":[{"source":"PubMed","id":"28874570","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues142
DetailsRegion: {"description":"Platform domain","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues94
DetailsRegion: {"description":"RNase III insertion domain a; involved in homodimerization","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues69
DetailsRegion: {"description":"Essential for efficient and high-fidelity siRNA production and siRNA loading","evidences":[{"source":"PubMed","id":"28416567","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues6
DetailsMotif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

251801

PDB entries from 2026-04-08

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