7VYQ

Short chain dehydrogenase (SCR) cryoEM structure with NADP and ethyl 4-chloroacetoacetate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003674	molecular_function	molecular_function
A	0004090	molecular_function	carbonyl reductase (NADPH) activity
A	0005575	cellular_component	cellular_component
A	0008150	biological_process	biological_process
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
B	0003674	molecular_function	molecular_function
B	0004090	molecular_function	carbonyl reductase (NADPH) activity
B	0005575	cellular_component	cellular_component
B	0008150	biological_process	biological_process
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
F	0003674	molecular_function	molecular_function
F	0004090	molecular_function	carbonyl reductase (NADPH) activity
F	0005575	cellular_component	cellular_component
F	0008150	biological_process	biological_process
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
G	0003674	molecular_function	molecular_function
G	0004090	molecular_function	carbonyl reductase (NADPH) activity
G	0005575	cellular_component	cellular_component
G	0008150	biological_process	biological_process
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"35801308","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"35801308","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"UniProtKB","id":"O93868","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35801308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DLM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35801308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DLM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---