7VV4
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| L | 0005179 | molecular_function | hormone activity |
| L | 0005576 | cellular_component | extracellular region |
| R | 0001819 | biological_process | positive regulation of cytokine production |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| R | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| R | 0016020 | cellular_component | membrane |
| R | 0016477 | biological_process | cell migration |
| R | 0016493 | molecular_function | C-C chemokine receptor activity |
| R | 0019233 | biological_process | sensory perception of pain |
| R | 0030431 | biological_process | sleep |
| R | 0032467 | biological_process | positive regulation of cytokinesis |
| R | 0032722 | biological_process | positive regulation of chemokine production |
| R | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| R | 0042923 | molecular_function | neuropeptide binding |
| R | 0043303 | biological_process | mast cell degranulation |
| R | 0045576 | biological_process | mast cell activation |
| R | 0048265 | biological_process | response to pain |
| R | 0070098 | biological_process | chemokine-mediated signaling pathway |
| R | 1902624 | biological_process | positive regulation of neutrophil migration |
| R | 1990595 | molecular_function | mast cell secretagogue receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. AGLsMLSTVSTERCLsV |
| Chain | Residue | Details |
| R | ALA115-VAL131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 43 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
