7VSH
Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in E1P state.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0090555 | molecular_function | phosphatidylethanolamine flippase activity |
| A | 0090556 | molecular_function | phosphatidylserine floppase activity |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140331 | biological_process | aminophospholipid translocation |
| A | 0140346 | molecular_function | phosphatidylserine flippase activity |
| A | 1990531 | cellular_component | phospholipid-translocating ATPase complex |
| C | 0005198 | molecular_function | structural molecule activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006855 | biological_process | xenobiotic transmembrane transport |
| C | 0006869 | biological_process | lipid transport |
| C | 0010976 | biological_process | positive regulation of neuron projection development |
| C | 0015247 | molecular_function | aminophospholipid flippase activity |
| C | 0015917 | biological_process | aminophospholipid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0030658 | cellular_component | transport vesicle membrane |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0031901 | cellular_component | early endosome membrane |
| C | 0031902 | cellular_component | late endosome membrane |
| C | 0035577 | cellular_component | azurophil granule membrane |
| C | 0035579 | cellular_component | specific granule membrane |
| C | 0036010 | biological_process | protein localization to endosome |
| C | 0045332 | biological_process | phospholipid translocation |
| C | 0061092 | biological_process | positive regulation of phospholipid translocation |
| C | 0070863 | biological_process | positive regulation of protein exit from endoplasmic reticulum |
| C | 0140331 | biological_process | aminophospholipid translocation |
| C | 1990531 | cellular_component | phospholipid-translocating ATPase complex |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP409-THR415 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 61 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| C | ALA2-THR49 | |
| A | TRP1067-LEU1087 | |
| C | ASN347-ILE361 | |
| A | ILE288-THR308 | |
| A | PHE344-GLU364 | |
| A | PHE877-PHE897 | |
| A | ALA906-LEU926 | |
| A | LEU953-GLY973 | |
| A | TRP993-LEU1013 | |
| A | PHE1024-ILE1044 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | VAL50-VAL70 | |
| C | GLY326-ILE346 | |
| A | SER898-ALA905 | |
| A | THR974-ASN992 | |
| A | TRP1045-THR1066 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 254 |
| Details | TOPO_DOM: Exoplasmic loop => ECO:0000255 |
| Chain | Residue | Details |
| C | THR71-LEU325 | |
| A | MET365-TYR876 | |
| A | GLU927-GLN952 | |
| A | ASP1014-HIS1023 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| C | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31416931, ECO:0007744|PDB:6K7G, ECO:0007744|PDB:6K7H, ECO:0007744|PDB:6K7I, ECO:0007744|PDB:6K7J, ECO:0007744|PDB:6K7K, ECO:0007744|PDB:6K7L, ECO:0007744|PDB:6K7M |
| Chain | Residue | Details |
| C | ASN107 | |
| A | LYS410 | |
| A | THR411 | |
| A | PHE540 | |
| A | ASN819 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:31416931, ECO:0007744|PDB:6K7G, ECO:0007744|PDB:6K7H, ECO:0007744|PDB:6K7I, ECO:0007744|PDB:6K7J, ECO:0007744|PDB:6K7K, ECO:0007744|PDB:6K7L, ECO:0007744|PDB:6K7M |
| Chain | Residue | Details |
| C | ASN180 | |
| A | LYS563 | |
| A | ARG594 | |
| A | THR674 | |
| A | GLY675 | |
| A | ASP676 | |
| A | ARG789 | |
| A | LYS795 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| C | ASN190 | |
| A | ASP820 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:31416931, ECO:0007744|PDB:6K7G, ECO:0007744|PDB:6K7H, ECO:0007744|PDB:6K7I, ECO:0007744|PDB:6K7J, ECO:0007744|PDB:6K7K, ECO:0007744|PDB:6K7L, ECO:0007744|PDB:6K7M |
| Chain | Residue | Details |
| C | ASN294 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:24904167 |
| Chain | Residue | Details |
| A | ASP445 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP3 and CASP7 => ECO:0000269|PubMed:24904167 |
| Chain | Residue | Details |
| A | ASP481 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER442 |
