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7VPK

Cryo-EM structure of the human ATP13A2 (SPM-bound E2P state)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0005215molecular_functiontransporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005771cellular_componentmultivesicular body
A0005776cellular_componentautophagosome
A0006874biological_processintracellular calcium ion homeostasis
A0006879biological_processintracellular iron ion homeostasis
A0006882biological_processintracellular zinc ion homeostasis
A0006914biological_processautophagy
A0007041biological_processlysosomal transport
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0010628biological_processpositive regulation of gene expression
A0010821biological_processregulation of mitochondrion organization
A0012506cellular_componentvesicle membrane
A0015203molecular_functionpolyamine transmembrane transporter activity
A0015417molecular_functionABC-type polyamine transporter activity
A0015662molecular_functionP-type ion transporter activity
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016243biological_processregulation of autophagosome size
A0016887molecular_functionATP hydrolysis activity
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030003biological_processintracellular monoatomic cation homeostasis
A0030133cellular_componenttransport vesicle
A0030145molecular_functionmanganese ion binding
A0031902cellular_componentlate endosome membrane
A0031982cellular_componentvesicle
A0032585cellular_componentmultivesicular body membrane
A0033157biological_processregulation of intracellular protein transport
A0034220biological_processmonoatomic ion transmembrane transport
A0034599biological_processcellular response to oxidative stress
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043202cellular_componentlysosomal lumen
A0043523biological_processregulation of neuron apoptotic process
A0046777biological_processprotein autophosphorylation
A0046872molecular_functionmetal ion binding
A0050714biological_processpositive regulation of protein secretion
A0052548biological_processregulation of endopeptidase activity
A0055085biological_processtransmembrane transport
A0055088biological_processlipid homeostasis
A0061462biological_processprotein localization to lysosome
A0061909biological_processautophagosome-lysosome fusion
A0070300molecular_functionphosphatidic acid binding
A0071287biological_processcellular response to manganese ion
A0071294biological_processcellular response to zinc ion
A0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
A0097734biological_processextracellular exosome biogenesis
A0098655biological_processmonoatomic cation transmembrane transport
A0140358molecular_functionP-type transmembrane transporter activity
A1900180biological_processregulation of protein localization to nucleus
A1902047biological_processpolyamine transmembrane transport
A1903135molecular_functioncupric ion binding
A1903146biological_processregulation of autophagy of mitochondrion
A1903543biological_processpositive regulation of exosomal secretion
A1903710biological_processspermine transmembrane transport
A1904714biological_processregulation of chaperone-mediated autophagy
A1905037biological_processautophagosome organization
A1905165biological_processregulation of lysosomal protein catabolic process
A1905166biological_processnegative regulation of lysosomal protein catabolic process
A1990938biological_processpeptidyl-aspartic acid autophosphorylation
A2000152biological_processregulation of ubiquitin-specific protease activity
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP513-THR519

site_idPS01229
Number of Residues23
DetailsCOF_2 Hypothetical cof family signature 2. CGDGaNDcgaLkaAdvGisLsqA
ChainResidueDetails
ACYS876-ALA898

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues873
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:26134396
ChainResidueDetails
AMET1-PRO44
AARG66-GLU235
ALYS277-LYS427
AGLN485-SER930
ASER979-GLY994
APRO1070-PRO1080
AASP1139-ARG1180

site_idSWS_FT_FI2
Number of Residues20
DetailsINTRAMEM: INTRAMEM => ECO:0000255
ChainResidueDetails
ATRP45-PHE65

site_idSWS_FT_FI3
Number of Residues196
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA236-ALA253
ALEU1118-LEU1138
ATYR257-TYR276
APHE428-TYR448
ALEU464-ALA484
APHE931-LEU951
ALEU958-MET978
AALA995-VAL1015
AVAL1049-ALA1069
APHE1081-LEU1101

site_idSWS_FT_FI4
Number of Residues68
DetailsTOPO_DOM: Lumenal => ECO:0000305|PubMed:26134396
ChainResidueDetails
AASP254-TYR256
AARG449-ASP463
ATYR952-ASN957
AGLN1016-THR1048
ALEU1102-LYS1117

site_idSWS_FT_FI5
Number of Residues1
DetailsACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269|PubMed:26134396
ChainResidueDetails
AASP513

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP878
AASP882

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER151

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26134396
ChainResidueDetails
AASN1033

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN1110

219515

PDB entries from 2024-05-08

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