Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7VOI

Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0017148biological_processnegative regulation of translation
A0030015cellular_componentCCR4-NOT core complex
B0000175molecular_function3'-5'-RNA exonuclease activity
B0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
B0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
B0000932cellular_componentP-body
B0003676molecular_functionnucleic acid binding
B0003714molecular_functiontranscription corepressor activity
B0003723molecular_functionRNA binding
B0004518molecular_functionnuclease activity
B0004527molecular_functionexonuclease activity
B0004532molecular_functionRNA exonuclease activity
B0004535molecular_functionpoly(A)-specific ribonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006417biological_processregulation of translation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0010629biological_processnegative regulation of gene expression
B0016020cellular_componentmembrane
B0016604cellular_componentnuclear body
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0030014cellular_componentCCR4-NOT complex
B0030015cellular_componentCCR4-NOT core complex
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0033962biological_processP-body assembly
B0034584molecular_functionpiRNA binding
B0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042509biological_processregulation of tyrosine phosphorylation of STAT protein
B0045070biological_processpositive regulation of viral genome replication
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0051607biological_processdefense response to virus
B0060213biological_processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0061014biological_processpositive regulation of mRNA catabolic process
B0140297molecular_functionDNA-binding transcription factor binding
B0140991biological_processpiRNA-mediated gene silencing by mRNA destabilization
B1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
C0000175molecular_function3'-5'-RNA exonuclease activity
C0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
C0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
C0003824molecular_functioncatalytic activity
C0004518molecular_functionnuclease activity
C0004527molecular_functionexonuclease activity
C0004535molecular_functionpoly(A)-specific ribonuclease activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006397biological_processmRNA processing
C0006417biological_processregulation of translation
C0008284biological_processpositive regulation of cell population proliferation
C0010606biological_processpositive regulation of cytoplasmic mRNA processing body assembly
C0016787molecular_functionhydrolase activity
C0030014cellular_componentCCR4-NOT complex
C0031047biological_processregulatory ncRNA-mediated gene silencing
C0046872molecular_functionmetal ion binding
C0061157biological_processmRNA destabilization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:20628353, ECO:0000305|PubMed:27013054
ChainResidueDetails
CASP410
BGLU42
BASP161
BASP230
BGLU278

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2
ChainResidueDetails
CGLU240
CHIS360
CASN412
CASN479

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGN
ChainResidueDetails
CGLU276

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20628353
ChainResidueDetails
CPRO365

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGQ
ChainResidueDetails
CASP410

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:5DV2
ChainResidueDetails
CPHE484

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon