7VFU
Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005891 | cellular_component | voltage-gated calcium channel complex |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
| A | 1904645 | biological_process | response to amyloid-beta |
| D | 0005245 | molecular_function | voltage-gated calcium channel activity |
| D | 0005246 | molecular_function | calcium channel regulator activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005891 | cellular_component | voltage-gated calcium channel complex |
| D | 0007268 | biological_process | chemical synaptic transmission |
| D | 0007528 | biological_process | neuromuscular junction development |
| D | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| D | 0030315 | cellular_component | T-tubule |
| D | 0034702 | cellular_component | monoatomic ion channel complex |
| D | 0042383 | cellular_component | sarcolemma |
| D | 0045202 | cellular_component | synapse |
| D | 0045933 | biological_process | positive regulation of muscle contraction |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 1902514 | biological_process | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| D | 1904646 | biological_process | cellular response to amyloid-beta |
| D | 1990454 | cellular_component | L-type voltage-gated calcium channel complex |
| E | 0005576 | cellular_component | extracellular region |
| E | 0008200 | molecular_function | ion channel inhibitor activity |
Functional Information from PROSITE/UniProt
| site_id | PS60004 |
| Number of Residues | 25 |
| Details | OMEGA_CONOTOXIN Omega-conotoxin family signature. CKgkGaKCSrl...MYdCCTg.SCr..SGKC |
| Chain | Residue | Details |
| E | CYS1-CYS25 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1048 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLU25-GLY1073 | |
| A | ILE1417-PRO1471 | |
| A | ALA1524-ASP1533 | |
| A | TYR1583-TYR1601 | |
| A | MET1708-CYS2339 | |
| D | SER47 | |
| D | SER73 | |
| D | SER193 | |
| E | ARG21 | |
| A | LYS587-ASN604 | |
| A | ASP710-TYR1151 | |
| A | ASP1204-ASP1217 | |
| A | PRO1266-LEU1283 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL1074-LEU1094 | |
| D | SER547 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL1095-LEU1103 | |
| A | LYS1491-GLU1498 | |
| A | ALA1556-ASN1563 | |
| A | GLY1622-PHE1683 | |
| A | GLY183-ASP187 | |
| A | TYR245-TRP331 | |
| A | VAL502-THR511 | |
| A | LYS567-GLY573 | |
| A | PHE631-GLY682 | |
| A | ASP1171-PRO1178 | |
| A | SER1239-ILE1244 | |
| A | PHE1304-MET1390 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | ASP259 | |
| B | SER261 | |
| B | SER263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54290 |
| Chain | Residue | Details |
| B | SER119 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| B | ASN92 | |
| B | ASN184 | |
| B | ASN348 | |
| B | ASN468 | |
| B | ASN613 | |
| B | ASN781 | |
| B | ASN895 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN136 | |
| B | ASN324 | |
| B | ASN475 | |
| B | ASN604 | |
| B | ASN675 | |
| B | ASN824 | |
| B | ASN888 | |
| B | ASN985 | |
| B | ASN998 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ASN332-SER356 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | SER483-MET501 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | THR512-TYR534 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | SER545-ILE566 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ILE574-PHE586 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | SER605-LEU630 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | MET683-VAL709 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | PHE1152-GLU1170 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ARG1179-ILE1203 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | LEU1218-GLY1238 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ASN1245-LEU1265 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ASN1284-LEU1303 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | GLU1391-ILE1416 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | PRO1472-MET1490 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | TYR1499-ILE1523 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ALA1534-ILE1555 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | LEU1564-GLY1582 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | VAL1602-PHE1621 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ALA1684-ILE1707 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA451 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | SER544 | |
| A | ARG584 | |
| A | LYS587 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ASP1737 | |
| A | ARG1743 | |
| A | ASP1748 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:O55017 |
| Chain | Residue | Details |
| A | ARG22 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O55017 |
| Chain | Residue | Details |
| A | SER411 | |
| A | SER745 | |
| A | SER748 | |
| A | SER783 | |
| A | SER1069 | |
| A | SER2066 | |
| A | SER2224 | |
| A | SER2233 | |
| A | SER2256 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| A | ASN256 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN1563 | |
| A | ASN1675 |
