7VDV

The overall structure of human chromatin remodeling PBAF-nucleosome complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0042393	molecular_function	histone binding
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0030527	molecular_function	structural constituent of chromatin
K	0046982	molecular_function	protein heterodimerization activity
N	0000723	biological_process	telomere maintenance
N	0000776	cellular_component	kinetochore
N	0000785	cellular_component	chromatin
N	0000786	cellular_component	nucleosome
N	0001825	biological_process	blastocyst formation
N	0003407	biological_process	neural retina development
N	0003682	molecular_function	chromatin binding
N	0003713	molecular_function	transcription coactivator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005886	cellular_component	plasma membrane
N	0006275	biological_process	regulation of DNA replication
N	0006281	biological_process	DNA repair
N	0006282	biological_process	regulation of DNA repair
N	0006310	biological_process	DNA recombination
N	0006325	biological_process	chromatin organization
N	0006338	biological_process	chromatin remodeling
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006974	biological_process	DNA damage response
N	0007165	biological_process	signal transduction
N	0007399	biological_process	nervous system development
N	0008284	biological_process	positive regulation of cell population proliferation
N	0016363	cellular_component	nuclear matrix
N	0016514	cellular_component	SWI/SNF complex
N	0016586	cellular_component	RSC-type complex
N	0021510	biological_process	spinal cord development
N	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
N	0031011	cellular_component	Ino80 complex
N	0031492	molecular_function	nucleosomal DNA binding
N	0032991	cellular_component	protein-containing complex
N	0033044	biological_process	regulation of chromosome organization
N	0035060	cellular_component	brahma complex
N	0035267	cellular_component	NuA4 histone acetyltransferase complex
N	0042981	biological_process	regulation of apoptotic process
N	0045582	biological_process	positive regulation of T cell differentiation
N	0045596	biological_process	negative regulation of cell differentiation
N	0045597	biological_process	positive regulation of cell differentiation
N	0045663	biological_process	positive regulation of myoblast differentiation
N	0045739	biological_process	positive regulation of DNA repair
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0045995	biological_process	regulation of embryonic development
N	0048731	biological_process	system development
N	0051726	biological_process	regulation of cell cycle
N	0060382	biological_process	regulation of DNA strand elongation
N	0070316	biological_process	regulation of G0 to G1 transition
N	0071564	cellular_component	npBAF complex
N	0140288	cellular_component	GBAF complex
N	1902459	biological_process	positive regulation of stem cell population maintenance
N	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
N	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
N	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
N	2000779	biological_process	regulation of double-strand break repair
N	2000781	biological_process	positive regulation of double-strand break repair
N	2000819	biological_process	regulation of nucleotide-excision repair
P	0000166	molecular_function	nucleotide binding
P	0000776	cellular_component	kinetochore
P	0000785	cellular_component	chromatin
P	0000786	cellular_component	nucleosome
P	0001738	biological_process	morphogenesis of a polarized epithelium
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005884	cellular_component	actin filament
P	0005886	cellular_component	plasma membrane
P	0005903	cellular_component	brush border
P	0005911	cellular_component	cell-cell junction
P	0005912	cellular_component	adherens junction
P	0005925	cellular_component	focal adhesion
P	0006338	biological_process	chromatin remodeling
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0007010	biological_process	cytoskeleton organization
P	0007163	biological_process	establishment or maintenance of cell polarity
P	0007409	biological_process	axonogenesis
P	0008284	biological_process	positive regulation of cell population proliferation
P	0015629	cellular_component	actin cytoskeleton
P	0016020	cellular_component	membrane
P	0016363	cellular_component	nuclear matrix
P	0016514	cellular_component	SWI/SNF complex
P	0016586	cellular_component	RSC-type complex
P	0016787	molecular_function	hydrolase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0019894	molecular_function	kinesin binding
P	0019901	molecular_function	protein kinase binding
P	0021762	biological_process	substantia nigra development
P	0030027	cellular_component	lamellipodium
P	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
P	0030235	molecular_function	nitric-oxide synthase regulator activity
P	0030424	cellular_component	axon
P	0030863	cellular_component	cortical cytoskeleton
P	0030957	molecular_function	Tat protein binding
P	0031492	molecular_function	nucleosomal DNA binding
P	0031982	cellular_component	vesicle
P	0032991	cellular_component	protein-containing complex
P	0034333	biological_process	adherens junction assembly
P	0035060	cellular_component	brahma complex
P	0035267	cellular_component	NuA4 histone acetyltransferase complex
P	0035633	biological_process	maintenance of blood-brain barrier
P	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
P	0042802	molecular_function	identical protein binding
P	0042981	biological_process	regulation of apoptotic process
P	0043296	cellular_component	apical junction complex
P	0044305	cellular_component	calyx of Held
P	0045176	biological_process	apical protein localization
P	0045202	cellular_component	synapse
P	0045582	biological_process	positive regulation of T cell differentiation
P	0045596	biological_process	negative regulation of cell differentiation
P	0045597	biological_process	positive regulation of cell differentiation
P	0045663	biological_process	positive regulation of myoblast differentiation
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0048156	molecular_function	tau protein binding
P	0048870	biological_process	cell motility
P	0050998	molecular_function	nitric-oxide synthase binding
P	0051621	biological_process	regulation of norepinephrine uptake
P	0051623	biological_process	positive regulation of norepinephrine uptake
P	0051726	biological_process	regulation of cell cycle
P	0070062	cellular_component	extracellular exosome
P	0070160	cellular_component	tight junction
P	0070316	biological_process	regulation of G0 to G1 transition
P	0070527	biological_process	platelet aggregation
P	0071564	cellular_component	npBAF complex
P	0071565	cellular_component	nBAF complex
P	0071896	biological_process	protein localization to adherens junction
P	0072562	cellular_component	blood microparticle
P	0072749	biological_process	cellular response to cytochalasin B
P	0097433	cellular_component	dense body
P	0098685	cellular_component	Schaffer collateral - CA1 synapse
P	0098793	cellular_component	presynapse
P	0098871	cellular_component	postsynaptic actin cytoskeleton
P	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
P	0098974	biological_process	postsynaptic actin cytoskeleton organization
P	0098978	cellular_component	glutamatergic synapse
P	0140092	cellular_component	bBAF complex
P	0140288	cellular_component	GBAF complex
P	0141108	molecular_function	transporter regulator activity
P	0150111	biological_process	regulation of transepithelial transport
P	1900242	biological_process	regulation of synaptic vesicle endocytosis
P	1902459	biological_process	positive regulation of stem cell population maintenance
P	1903076	biological_process	regulation of protein localization to plasma membrane
P	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
P	1990904	cellular_component	ribonucleoprotein complex
P	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
P	2000779	biological_process	regulation of double-strand break repair
P	2000781	biological_process	positive regulation of double-strand break repair
P	2000819	biological_process	regulation of nucleotide-excision repair
Q	0003677	molecular_function	DNA binding
Q	0006355	biological_process	regulation of DNA-templated transcription
R	0000776	cellular_component	kinetochore
R	0000785	cellular_component	chromatin
R	0003682	molecular_function	chromatin binding
R	0003712	molecular_function	transcription coregulator activity
R	0004402	molecular_function	histone acetyltransferase activity
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0006338	biological_process	chromatin remodeling
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0007399	biological_process	nervous system development
R	0008270	molecular_function	zinc ion binding
R	0016363	cellular_component	nuclear matrix
R	0016514	cellular_component	SWI/SNF complex
R	0016586	cellular_component	RSC-type complex
R	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
R	0045582	biological_process	positive regulation of T cell differentiation
R	0045597	biological_process	positive regulation of cell differentiation
R	0045663	biological_process	positive regulation of myoblast differentiation
R	0046872	molecular_function	metal ion binding
R	0070316	biological_process	regulation of G0 to G1 transition
R	0071564	cellular_component	npBAF complex
R	1902459	biological_process	positive regulation of stem cell population maintenance
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
R	2000781	biological_process	positive regulation of double-strand break repair
R	2000819	biological_process	regulation of nucleotide-excision repair
V	0000228	cellular_component	nuclear chromosome
V	0000776	cellular_component	kinetochore
V	0000785	cellular_component	chromatin
V	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
V	0001188	biological_process	RNA polymerase I preinitiation complex assembly
V	0001650	cellular_component	fibrillar center
V	0001741	cellular_component	XY body
V	0001824	biological_process	blastocyst development
V	0001835	biological_process	blastocyst hatching
V	0002039	molecular_function	p53 binding
V	0003677	molecular_function	DNA binding
V	0003713	molecular_function	transcription coactivator activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005730	cellular_component	nucleolus
V	0006325	biological_process	chromatin organization
V	0006337	biological_process	nucleosome disassembly
V	0006338	biological_process	chromatin remodeling
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0007399	biological_process	nervous system development
V	0008285	biological_process	negative regulation of cell population proliferation
V	0015074	biological_process	DNA integration
V	0016363	cellular_component	nuclear matrix
V	0016514	cellular_component	SWI/SNF complex
V	0016586	cellular_component	RSC-type complex
V	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
V	0030957	molecular_function	Tat protein binding
V	0031492	molecular_function	nucleosomal DNA binding
V	0032991	cellular_component	protein-containing complex
V	0035060	cellular_component	brahma complex
V	0039692	biological_process	single stranded viral RNA replication via double stranded DNA intermediate
V	0042802	molecular_function	identical protein binding
V	0043073	cellular_component	germ cell nucleus
V	0043923	biological_process	positive regulation by host of viral transcription
V	0045582	biological_process	positive regulation of T cell differentiation
V	0045597	biological_process	positive regulation of cell differentiation
V	0045663	biological_process	positive regulation of myoblast differentiation
V	0045815	biological_process	transcription initiation-coupled chromatin remodeling
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0070316	biological_process	regulation of G0 to G1 transition
V	0070365	biological_process	hepatocyte differentiation
V	0071564	cellular_component	npBAF complex
V	0071565	cellular_component	nBAF complex
V	0140092	cellular_component	bBAF complex
V	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
V	1902459	biological_process	positive regulation of stem cell population maintenance
V	1902661	biological_process	positive regulation of glucose mediated signaling pathway
V	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
V	2000781	biological_process	positive regulation of double-strand break repair
V	2000819	biological_process	regulation of nucleotide-excision repair
W	0000776	cellular_component	kinetochore
W	0000785	cellular_component	chromatin
W	0003713	molecular_function	transcription coactivator activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0006325	biological_process	chromatin organization
W	0006337	biological_process	nucleosome disassembly
W	0006338	biological_process	chromatin remodeling
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0007399	biological_process	nervous system development
W	0016363	cellular_component	nuclear matrix
W	0016514	cellular_component	SWI/SNF complex
W	0016586	cellular_component	RSC-type complex
W	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
W	0031492	molecular_function	nucleosomal DNA binding
W	0032991	cellular_component	protein-containing complex
W	0035060	cellular_component	brahma complex
W	0042393	molecular_function	histone binding
W	0045582	biological_process	positive regulation of T cell differentiation
W	0045597	biological_process	positive regulation of cell differentiation
W	0045663	biological_process	positive regulation of myoblast differentiation
W	0045892	biological_process	negative regulation of DNA-templated transcription
W	0045893	biological_process	positive regulation of DNA-templated transcription
W	0070316	biological_process	regulation of G0 to G1 transition
W	0071564	cellular_component	npBAF complex
W	0071565	cellular_component	nBAF complex
W	0140092	cellular_component	bBAF complex
W	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
W	2000781	biological_process	positive regulation of double-strand break repair
W	2000819	biological_process	regulation of nucleotide-excision repair
X	0000776	cellular_component	kinetochore
X	0000785	cellular_component	chromatin
X	0003713	molecular_function	transcription coactivator activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0006325	biological_process	chromatin organization
X	0006337	biological_process	nucleosome disassembly
X	0006338	biological_process	chromatin remodeling
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0007399	biological_process	nervous system development
X	0016363	cellular_component	nuclear matrix
X	0016514	cellular_component	SWI/SNF complex
X	0016586	cellular_component	RSC-type complex
X	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
X	0031492	molecular_function	nucleosomal DNA binding
X	0032991	cellular_component	protein-containing complex
X	0035060	cellular_component	brahma complex
X	0042393	molecular_function	histone binding
X	0045582	biological_process	positive regulation of T cell differentiation
X	0045597	biological_process	positive regulation of cell differentiation
X	0045663	biological_process	positive regulation of myoblast differentiation
X	0045892	biological_process	negative regulation of DNA-templated transcription
X	0045893	biological_process	positive regulation of DNA-templated transcription
X	0070316	biological_process	regulation of G0 to G1 transition
X	0071564	cellular_component	npBAF complex
X	0071565	cellular_component	nBAF complex
X	0140092	cellular_component	bBAF complex
X	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
X	2000781	biological_process	positive regulation of double-strand break repair
X	2000819	biological_process	regulation of nucleotide-excision repair
Y	0000776	cellular_component	kinetochore
Y	0000785	cellular_component	chromatin
Y	0003682	molecular_function	chromatin binding
Y	0003712	molecular_function	transcription coregulator activity
Y	0003713	molecular_function	transcription coactivator activity
Y	0005102	molecular_function	signaling receptor binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006325	biological_process	chromatin organization
Y	0006337	biological_process	nucleosome disassembly
Y	0006338	biological_process	chromatin remodeling
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0007399	biological_process	nervous system development
Y	0008284	biological_process	positive regulation of cell population proliferation
Y	0016363	cellular_component	nuclear matrix
Y	0016514	cellular_component	SWI/SNF complex
Y	0016586	cellular_component	RSC-type complex
Y	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
Y	0035060	cellular_component	brahma complex
Y	0045582	biological_process	positive regulation of T cell differentiation
Y	0045596	biological_process	negative regulation of cell differentiation
Y	0045597	biological_process	positive regulation of cell differentiation
Y	0045663	biological_process	positive regulation of myoblast differentiation
Y	0045815	biological_process	transcription initiation-coupled chromatin remodeling
Y	0045893	biological_process	positive regulation of DNA-templated transcription
Y	0060090	molecular_function	molecular adaptor activity
Y	0070316	biological_process	regulation of G0 to G1 transition
Y	0071398	biological_process	cellular response to fatty acid
Y	0071564	cellular_component	npBAF complex
Y	0071565	cellular_component	nBAF complex
Y	0140288	cellular_component	GBAF complex
Y	1902459	biological_process	positive regulation of stem cell population maintenance
Y	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Y	2000781	biological_process	positive regulation of double-strand break repair
Y	2000819	biological_process	regulation of nucleotide-excision repair
Z	0000228	cellular_component	nuclear chromosome
Z	0000776	cellular_component	kinetochore
Z	0000785	cellular_component	chromatin
Z	0003677	molecular_function	DNA binding
Z	0003682	molecular_function	chromatin binding
Z	0003713	molecular_function	transcription coactivator activity
Z	0003723	molecular_function	RNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006325	biological_process	chromatin organization
Z	0006337	biological_process	nucleosome disassembly
Z	0006338	biological_process	chromatin remodeling
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0007399	biological_process	nervous system development
Z	0008080	molecular_function	N-acetyltransferase activity
Z	0016363	cellular_component	nuclear matrix
Z	0016514	cellular_component	SWI/SNF complex
Z	0016586	cellular_component	RSC-type complex
Z	0016922	molecular_function	nuclear receptor binding
Z	0022008	biological_process	neurogenesis
Z	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
Z	0031492	molecular_function	nucleosomal DNA binding
Z	0032991	cellular_component	protein-containing complex
Z	0035060	cellular_component	brahma complex
Z	0045582	biological_process	positive regulation of T cell differentiation
Z	0045597	biological_process	positive regulation of cell differentiation
Z	0045663	biological_process	positive regulation of myoblast differentiation
Z	0045892	biological_process	negative regulation of DNA-templated transcription
Z	0045893	biological_process	positive regulation of DNA-templated transcription
Z	0070316	biological_process	regulation of G0 to G1 transition
Z	0071564	cellular_component	npBAF complex
Z	0071565	cellular_component	nBAF complex
Z	0140092	cellular_component	bBAF complex
Z	1902459	biological_process	positive regulation of stem cell population maintenance
Z	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Z	2000781	biological_process	positive regulation of double-strand break repair
Z	2000819	biological_process	regulation of nucleotide-excision repair
a	0003682	molecular_function	chromatin binding
a	0006338	biological_process	chromatin remodeling
a	0016586	cellular_component	RSC-type complex

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	24
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. ClwqsCkkwFqtpsqvfyHaate.H

Chain	Residue	Details
Q	CYS1634-HIS1657

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site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

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site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDSGATHTTA

Chain	Residue	Details
N	LEU168-ALA179

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site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
E	LYS14-LEU20

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

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site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
P	TYR53-GLY63

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site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
P	TRP356-GLU364
N	TRP410-GLU418

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site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY

Chain	Residue	Details
a	SER721-TYR778
A	SER1449-PHE1506

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
E	PRO66-ILE74

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site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
P	LEU104-ARG116

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site_id	PS01359
Number of Residues	78
Details	ZF_PHD_1 Zinc finger PHD-type signature. CsqCensghpscldmtmelvsmiktypwqcmecktciicgqphheeem.MfCdm..Cdrg.YHtfCvglgaipsgr...................................WiCdcC

Chain	Residue	Details
R	CYS401-CYS478

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Citrulline; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	ARG2
E	ARG17
K	ARG2
K	ARG17
H	LYS5
H	LYS12
H	LYS15
H	LYS20

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	THR3
K	THR3
V	LYS108
V	LYS124
V	LYS161

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12138181

Chain	Residue	Details
E	LYS4
K	LYS4
G	LYS9
G	LYS95

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	GLN5
K	GLN5
H	LYS120
Z	LYS166
Z	LYS277

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	THR6
E	THR11
K	THR6
K	THR11
F	LYS8
F	LYS16
F	LYS44
F	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250

Chain	Residue	Details
E	ARG8
K	ARG8
F	LYS12
F	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:12138181

Chain	Residue	Details
E	LYS9
K	LYS9
T	LYS305
F	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	SER10
T	LYS389
K	SER10
C	LYS15
C	LYS119
G	LYS13
T	LYS212
G	LYS15
G	LYS119
T	LYS344

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
E	LYS14
K	LYS14
a	LYS1146
a	LYS1151
a	LYS1207
a	GLN1682
Q	LYS1716
Q	LYS1731

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	LYS18
K	LYS64
E	LYS23
E	LYS27
E	LYS36
E	LYS64
K	LYS18
K	LYS23
K	LYS27
K	LYS36

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Citrulline => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	ARG26
K	ARG26

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	SER28
K	SER28
W	LYS592
W	LYS787
X	LYS564
X	LYS568
X	LYS592
X	LYS787

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
E	LYS37
K	LYS37
X	LYS848

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	TYR41
K	TYR41
X	LYS566
X	LYS704

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
E	LYS56
E	LYS79
K	LYS56
K	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	SER57
K	SER57

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	THR80
E	THR107
K	THR80
K	THR107

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
E	SER86
K	SER86

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	LYS115
K	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	LYS122
K	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
E	CYS110
K	CYS110

---