Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7V9A

biogenesis module of human telomerase holoenzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000781	cellular_component	chromosome, telomeric region
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005697	cellular_component	telomerase holoenzyme complex
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0007004	biological_process	telomere maintenance via telomerase
B	0015030	cellular_component	Cajal body
B	0016604	cellular_component	nuclear body
B	0030576	biological_process	Cajal body organization
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032203	biological_process	telomere formation via telomerase
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0034337	biological_process	RNA folding
B	0035861	cellular_component	site of double-strand break
B	0042393	molecular_function	histone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0045739	biological_process	positive regulation of DNA repair
B	0051087	molecular_function	protein-folding chaperone binding
B	0070034	molecular_function	telomerase RNA binding
B	0090666	biological_process	scaRNA localization to Cajal body
B	0090671	biological_process	telomerase RNA localization to Cajal body
B	0140597	molecular_function	protein carrier chaperone
B	0140691	molecular_function	RNA folding chaperone
B	1904851	biological_process	positive regulation of establishment of protein localization to telomere
B	1904867	biological_process	protein localization to Cajal body
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	2000781	biological_process	positive regulation of double-strand break repair
B	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
C	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
C	0000495	biological_process	box H/ACA sno(s)RNA 3'-end processing
C	0001522	biological_process	pseudouridine synthesis
C	0001650	cellular_component	fibrillar center
C	0003720	molecular_function	telomerase activity
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005697	cellular_component	telomerase holoenzyme complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0007004	biological_process	telomere maintenance via telomerase
C	0009451	biological_process	RNA modification
C	0009982	molecular_function	pseudouridine synthase activity
C	0015030	cellular_component	Cajal body
C	0016853	molecular_function	isomerase activity
C	0031118	biological_process	rRNA pseudouridine synthesis
C	0031120	biological_process	snRNA pseudouridine synthesis
C	0031429	cellular_component	box H/ACA snoRNP complex
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0033979	biological_process	box H/ACA sno(s)RNA metabolic process
C	0034513	molecular_function	box H/ACA snoRNA binding
C	0042254	biological_process	ribosome biogenesis
C	0070034	molecular_function	telomerase RNA binding
C	0072589	cellular_component	box H/ACA scaRNP complex
C	0090661	cellular_component	box H/ACA telomerase RNP complex
C	0090666	biological_process	scaRNA localization to Cajal body
C	0090669	biological_process	telomerase RNA stabilization
C	1904867	biological_process	protein localization to Cajal body
C	1904872	biological_process	regulation of telomerase RNA localization to Cajal body
C	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
C	1905323	biological_process	telomerase holoenzyme complex assembly
C	1990481	biological_process	mRNA pseudouridine synthesis
C	1990904	cellular_component	ribonucleoprotein complex
D	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
D	0000781	cellular_component	chromosome, telomeric region
D	0001522	biological_process	pseudouridine synthesis
D	0001650	cellular_component	fibrillar center
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005697	cellular_component	telomerase holoenzyme complex
D	0005730	cellular_component	nucleolus
D	0006364	biological_process	rRNA processing
D	0007004	biological_process	telomere maintenance via telomerase
D	0015030	cellular_component	Cajal body
D	0031429	cellular_component	box H/ACA snoRNP complex
D	0034513	molecular_function	box H/ACA snoRNA binding
D	0042254	biological_process	ribosome biogenesis
D	0070034	molecular_function	telomerase RNA binding
D	0072589	cellular_component	box H/ACA scaRNP complex
D	0090661	cellular_component	box H/ACA telomerase RNP complex
D	1990904	cellular_component	ribonucleoprotein complex
E	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
E	0000781	cellular_component	chromosome, telomeric region
E	0003723	molecular_function	RNA binding
E	0003730	molecular_function	mRNA 3'-UTR binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005730	cellular_component	nucleolus
E	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
E	0006364	biological_process	rRNA processing
E	0007004	biological_process	telomere maintenance via telomerase
E	0015030	cellular_component	Cajal body
E	0031118	biological_process	rRNA pseudouridine synthesis
E	0031120	biological_process	snRNA pseudouridine synthesis
E	0031429	cellular_component	box H/ACA snoRNP complex
E	0034511	molecular_function	U3 snoRNA binding
E	0034513	molecular_function	box H/ACA snoRNA binding
E	0042254	biological_process	ribosome biogenesis
E	0070034	molecular_function	telomerase RNA binding
E	0072589	cellular_component	box H/ACA scaRNP complex
E	0090661	cellular_component	box H/ACA telomerase RNP complex
E	0090671	biological_process	telomerase RNA localization to Cajal body
E	1990904	cellular_component	ribonucleoprotein complex
F	0001522	biological_process	pseudouridine synthesis
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005697	cellular_component	telomerase holoenzyme complex
F	0005730	cellular_component	nucleolus
F	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
F	0006364	biological_process	rRNA processing
F	0007004	biological_process	telomere maintenance via telomerase
F	0015030	cellular_component	Cajal body
F	0016604	cellular_component	nuclear body
F	0030515	molecular_function	snoRNA binding
F	0031118	biological_process	rRNA pseudouridine synthesis
F	0031120	biological_process	snRNA pseudouridine synthesis
F	0031429	cellular_component	box H/ACA snoRNP complex
F	0034513	molecular_function	box H/ACA snoRNA binding
F	0042254	biological_process	ribosome biogenesis
F	0070034	molecular_function	telomerase RNA binding
F	0072589	cellular_component	box H/ACA scaRNP complex
F	0090661	cellular_component	box H/ACA telomerase RNP complex
F	0090671	biological_process	telomerase RNA localization to Cajal body
F	1990904	cellular_component	ribonucleoprotein complex
G	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
G	0000495	biological_process	box H/ACA sno(s)RNA 3'-end processing
G	0001522	biological_process	pseudouridine synthesis
G	0001650	cellular_component	fibrillar center
G	0003720	molecular_function	telomerase activity
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005697	cellular_component	telomerase holoenzyme complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006364	biological_process	rRNA processing
G	0006396	biological_process	RNA processing
G	0007004	biological_process	telomere maintenance via telomerase
G	0009451	biological_process	RNA modification
G	0009982	molecular_function	pseudouridine synthase activity
G	0015030	cellular_component	Cajal body
G	0016853	molecular_function	isomerase activity
G	0031118	biological_process	rRNA pseudouridine synthesis
G	0031120	biological_process	snRNA pseudouridine synthesis
G	0031429	cellular_component	box H/ACA snoRNP complex
G	0032212	biological_process	positive regulation of telomere maintenance via telomerase
G	0033979	biological_process	box H/ACA sno(s)RNA metabolic process
G	0034513	molecular_function	box H/ACA snoRNA binding
G	0042254	biological_process	ribosome biogenesis
G	0070034	molecular_function	telomerase RNA binding
G	0072589	cellular_component	box H/ACA scaRNP complex
G	0090661	cellular_component	box H/ACA telomerase RNP complex
G	0090666	biological_process	scaRNA localization to Cajal body
G	0090669	biological_process	telomerase RNA stabilization
G	1904867	biological_process	protein localization to Cajal body
G	1904872	biological_process	regulation of telomerase RNA localization to Cajal body
G	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
G	1905323	biological_process	telomerase holoenzyme complex assembly
G	1990481	biological_process	mRNA pseudouridine synthesis
G	1990904	cellular_component	ribonucleoprotein complex
H	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
H	0000781	cellular_component	chromosome, telomeric region
H	0001522	biological_process	pseudouridine synthesis
H	0001650	cellular_component	fibrillar center
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005697	cellular_component	telomerase holoenzyme complex
H	0005730	cellular_component	nucleolus
H	0006364	biological_process	rRNA processing
H	0007004	biological_process	telomere maintenance via telomerase
H	0015030	cellular_component	Cajal body
H	0031429	cellular_component	box H/ACA snoRNP complex
H	0034513	molecular_function	box H/ACA snoRNA binding
H	0042254	biological_process	ribosome biogenesis
H	0070034	molecular_function	telomerase RNA binding
H	0072589	cellular_component	box H/ACA scaRNP complex
H	0090661	cellular_component	box H/ACA telomerase RNP complex
H	1990904	cellular_component	ribonucleoprotein complex
I	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
I	0000781	cellular_component	chromosome, telomeric region
I	0003723	molecular_function	RNA binding
I	0003730	molecular_function	mRNA 3'-UTR binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005697	cellular_component	telomerase holoenzyme complex
I	0005730	cellular_component	nucleolus
I	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
I	0006364	biological_process	rRNA processing
I	0007004	biological_process	telomere maintenance via telomerase
I	0015030	cellular_component	Cajal body
I	0031118	biological_process	rRNA pseudouridine synthesis
I	0031120	biological_process	snRNA pseudouridine synthesis
I	0031429	cellular_component	box H/ACA snoRNP complex
I	0034511	molecular_function	U3 snoRNA binding
I	0034513	molecular_function	box H/ACA snoRNA binding
I	0042254	biological_process	ribosome biogenesis
I	0070034	molecular_function	telomerase RNA binding
I	0072589	cellular_component	box H/ACA scaRNP complex
I	0090661	cellular_component	box H/ACA telomerase RNP complex
I	0090671	biological_process	telomerase RNA localization to Cajal body
I	1990904	cellular_component	ribonucleoprotein complex
J	0001522	biological_process	pseudouridine synthesis
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005697	cellular_component	telomerase holoenzyme complex
J	0005730	cellular_component	nucleolus
J	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
J	0006364	biological_process	rRNA processing
J	0007004	biological_process	telomere maintenance via telomerase
J	0015030	cellular_component	Cajal body
J	0016604	cellular_component	nuclear body
J	0030515	molecular_function	snoRNA binding
J	0031118	biological_process	rRNA pseudouridine synthesis
J	0031120	biological_process	snRNA pseudouridine synthesis
J	0031429	cellular_component	box H/ACA snoRNP complex
J	0034513	molecular_function	box H/ACA snoRNA binding
J	0042254	biological_process	ribosome biogenesis
J	0070034	molecular_function	telomerase RNA binding
J	0072589	cellular_component	box H/ACA scaRNP complex
J	0090661	cellular_component	box H/ACA telomerase RNP complex
J	0090671	biological_process	telomerase RNA localization to Cajal body
J	1990904	cellular_component	ribonucleoprotein complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
E	SER19
I	SER19
H	LYS134

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
E	LYS3
I	LYS3

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25114211, ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
C	SER21
E	LYS5
I	LYS5

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER387
G	SER387

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER451
C	SER453
G	SER451
G	SER453

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
C	SER455
G	SER455

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q9ESX5

Chain	Residue	Details
C	THR458
G	THR458

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER485
G	SER485

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
C	SER494
G	SER494

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER513
G	SER513

site_id	SWS_FT_FI11
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
C	LYS20
G	LYS20
G	LYS39
G	LYS43
G	LYS191
G	LYS394
G	LYS424
G	LYS433
G	LYS467
C	LYS39
C	LYS43
C	LYS191
C	LYS394
C	LYS424
C	LYS433
C	LYS467

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
C	LYS413
G	LYS413

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)