7V8G

Crystal structure of HOIP RING1 domain bound to IpaH1.4 LRR domain

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0071797	cellular_component	LUBAC complex
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0071797	cellular_component	LUBAC complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	ZN_FING: RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
D	CYS699-ARG749
C	CYS699-ARG749

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:35294289, ECO:0007744|PDB:7V8F, ECO:0007744|PDB:7V8G

Chain	Residue	Details
D	CYS699
D	CYS702
D	CYS722
D	CYS725
C	CYS699
C	CYS702
C	CYS722
C	CYS725

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:35294289, ECO:0007744|PDB:7V8F, ECO:0007744|PDB:7V8G

Chain	Residue	Details
D	CYS717
D	CYS719
D	CYS744
D	CYS747
C	CYS717
C	CYS719
C	CYS744
C	CYS747

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site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27572974

Chain	Residue	Details
D	LYS735
D	LYS783
C	LYS735
C	LYS783

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