7V8F

Crystal structure of UBE2L3 bound to HOIP RING1 domain.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0000209	biological_process	protein polyubiquitination
A	0003713	molecular_function	transcription coactivator activity
A	0003723	molecular_function	RNA binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008283	biological_process	cell population proliferation
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0019787	molecular_function	ubiquitin-like protein transferase activity
A	0019899	molecular_function	enzyme binding
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032446	biological_process	protein modification by small protein conjugation
A	0036211	biological_process	protein modification process
A	0044770	biological_process	cell cycle phase transition
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0051443	biological_process	positive regulation of ubiquitin-protein transferase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070979	biological_process	protein K11-linked ubiquitination
A	0071383	biological_process	cellular response to steroid hormone stimulus
A	0071385	biological_process	cellular response to glucocorticoid stimulus
A	0097027	molecular_function	ubiquitin-protein transferase activator activity
A	0098793	cellular_component	presynapse
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0071797	cellular_component	LUBAC complex

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdek.GqVCLpvI

Chain	Residue	Details
A	TYR75-ILE90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133

Chain	Residue	Details
A	CYS86

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS131
B	CYS702
B	CYS722
B	CYS725

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35294289, ECO:0007744|PDB:7V8F, ECO:0007744|PDB:7V8G

Chain	Residue	Details
B	CYS717
B	CYS719
B	CYS744
B	CYS747

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27572974

Chain	Residue	Details
B	LYS735
B	LYS783

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 438

Chain	Residue	Details
A	CYS86	nucleofuge

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