7V8F
Crystal structure of UBE2L3 bound to HOIP RING1 domain.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000151 | cellular_component | ubiquitin ligase complex |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0031398 | biological_process | positive regulation of protein ubiquitination |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032446 | biological_process | protein modification by small protein conjugation |
| A | 0036211 | biological_process | protein modification process |
| A | 0044770 | biological_process | cell cycle phase transition |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| A | 0070979 | biological_process | protein K11-linked ubiquitination |
| A | 0071383 | biological_process | cellular response to steroid hormone stimulus |
| A | 0071385 | biological_process | cellular response to glucocorticoid stimulus |
| A | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| A | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0071797 | cellular_component | LUBAC complex |
Functional Information from PROSITE/UniProt
| site_id | PS00183 |
| Number of Residues | 16 |
| Details | UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdek.GqVCLpvI |
| Chain | Residue | Details |
| A | TYR75-ILE90 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"RING-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"35294289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7V8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V8G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"35294289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7V8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V8G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27572974","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 147 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
