7V2D

Deactive state complex I from Q10 dataset

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003954	molecular_function	NADH dehydrogenase activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005747	cellular_component	mitochondrial respiratory chain complex I
A	0005829	cellular_component	cytosol
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0010181	molecular_function	FMN binding
A	0016020	cellular_component	membrane
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0045271	cellular_component	respiratory chain complex I
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0055085	biological_process	transmembrane transport
A	0070469	cellular_component	respirasome
B	0016020	cellular_component	membrane
B	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0048038	molecular_function	quinone binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0005747	cellular_component	mitochondrial respiratory chain complex I
G	0006633	biological_process	fatty acid biosynthetic process
H	0022904	biological_process	respiratory electron transport chain
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005747	cellular_component	mitochondrial respiratory chain complex I
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0016020	cellular_component	membrane
I	0042773	biological_process	ATP synthesis coupled electron transport
K	0005739	cellular_component	mitochondrion
K	0005747	cellular_component	mitochondrial respiratory chain complex I
L	0022900	biological_process	electron transport chain
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005743	cellular_component	mitochondrial inner membrane
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045333	biological_process	cellular respiration
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
M	0055085	biological_process	transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005747	cellular_component	mitochondrial respiratory chain complex I
N	0006979	biological_process	response to oxidative stress
N	0016020	cellular_component	membrane
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0070469	cellular_component	respirasome
O	0016491	molecular_function	oxidoreductase activity
P	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
P	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0003954	molecular_function	NADH dehydrogenase activity
Q	0005654	cellular_component	nucleoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005747	cellular_component	mitochondrial respiratory chain complex I
Q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Q	0006979	biological_process	response to oxidative stress
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0019826	molecular_function	oxygen sensor activity
Q	0022008	biological_process	neurogenesis
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0042063	biological_process	gliogenesis
Q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Q	0048038	molecular_function	quinone binding
Q	0051287	molecular_function	NAD binding
Q	0051536	molecular_function	iron-sulfur cluster binding
Q	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Q	0055085	biological_process	transmembrane transport
Q	0061351	biological_process	neural precursor cell proliferation
Q	0071453	biological_process	cellular response to oxygen levels
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	mitochondrial respiratory chain complex I
S	0016020	cellular_component	membrane
S	0031966	cellular_component	mitochondrial membrane
S	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S	0070469	cellular_component	respirasome
T	0005747	cellular_component	mitochondrial respiratory chain complex I
T	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0005743	cellular_component	mitochondrial inner membrane
U	0005747	cellular_component	mitochondrial respiratory chain complex I
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005747	cellular_component	mitochondrial respiratory chain complex I
V	0016020	cellular_component	membrane
V	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005747	cellular_component	mitochondrial respiratory chain complex I
W	0016020	cellular_component	membrane
W	0070469	cellular_component	respirasome
X	0006633	biological_process	fatty acid biosynthetic process
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	mitochondrial respiratory chain complex I
Z	0005739	cellular_component	mitochondrion
Z	0022900	biological_process	electron transport chain
b	0005747	cellular_component	mitochondrial respiratory chain complex I
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
c	0005739	cellular_component	mitochondrion
c	0005747	cellular_component	mitochondrial respiratory chain complex I
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
f	0005739	cellular_component	mitochondrion
f	0005747	cellular_component	mitochondrial respiratory chain complex I
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005747	cellular_component	mitochondrial respiratory chain complex I
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
g	0016020	cellular_component	membrane
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0070469	cellular_component	respirasome
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005747	cellular_component	mitochondrial respiratory chain complex I
h	0005758	cellular_component	mitochondrial intermembrane space
h	0016020	cellular_component	membrane
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0070469	cellular_component	respirasome
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005747	cellular_component	mitochondrial respiratory chain complex I
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0016020	cellular_component	membrane
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0055085	biological_process	transmembrane transport
i	0070469	cellular_component	respirasome
i	0072593	biological_process	reactive oxygen species metabolic process
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005747	cellular_component	mitochondrial respiratory chain complex I
j	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0016020	cellular_component	membrane
j	0055085	biological_process	transmembrane transport
j	0070469	cellular_component	respirasome
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005747	cellular_component	mitochondrial respiratory chain complex I
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0016020	cellular_component	membrane
k	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
k	0042773	biological_process	ATP synthesis coupled electron transport
k	0055085	biological_process	transmembrane transport
k	0070469	cellular_component	respirasome
l	0003954	molecular_function	NADH dehydrogenase activity
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005747	cellular_component	mitochondrial respiratory chain complex I
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0015990	biological_process	electron transport coupled proton transport
l	0016020	cellular_component	membrane
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042773	biological_process	ATP synthesis coupled electron transport
l	0070469	cellular_component	respirasome
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0005747	cellular_component	mitochondrial respiratory chain complex I
m	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
m	0016020	cellular_component	membrane
m	0032981	biological_process	mitochondrial respiratory chain complex I assembly
m	0055085	biological_process	transmembrane transport
m	0070469	cellular_component	respirasome
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005747	cellular_component	mitochondrial respiratory chain complex I
n	0016607	cellular_component	nuclear speck
n	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0005654	cellular_component	nucleoplasm
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005747	cellular_component	mitochondrial respiratory chain complex I
o	0006979	biological_process	response to oxidative stress
o	0016020	cellular_component	membrane
o	0032981	biological_process	mitochondrial respiratory chain complex I assembly
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0015990	biological_process	electron transport coupled proton transport
r	0016020	cellular_component	membrane
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0045271	cellular_component	respiratory chain complex I
r	0048039	molecular_function	ubiquinone binding
r	0070469	cellular_component	respirasome
s	0003954	molecular_function	NADH dehydrogenase activity
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0005747	cellular_component	mitochondrial respiratory chain complex I
s	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0009060	biological_process	aerobic respiration
s	0016020	cellular_component	membrane
s	0032981	biological_process	mitochondrial respiratory chain complex I assembly
s	0055085	biological_process	transmembrane transport
s	0070469	cellular_component	respirasome
u	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
v	0005739	cellular_component	mitochondrion
v	0005743	cellular_component	mitochondrial inner membrane
v	0005747	cellular_component	mitochondrial respiratory chain complex I
v	0005758	cellular_component	mitochondrial intermembrane space
v	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
v	0016020	cellular_component	membrane
v	0032981	biological_process	mitochondrial respiratory chain complex I assembly
v	0055085	biological_process	transmembrane transport
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005747	cellular_component	mitochondrial respiratory chain complex I
w	0005759	cellular_component	mitochondrial matrix
w	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
w	0019136	molecular_function	deoxynucleoside kinase activity
w	0070469	cellular_component	respirasome

Functional Information from PROSITE/UniProt

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
M	PRO61-CYS78

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site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
M	CYS128-GLN140

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
M	ARG175-PHE185

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
Q	LEU116-LYS127

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
A	GLY200-SER215

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
A	GLU377-GLY388

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
O	ASP166-PRO184

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
B	CYS113-PRO124
B	CYS152-PRO163

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
C	GLY152-PRO168

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
P	GLU167-LEU188

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDALKLFtKE

Chain	Residue	Details
s	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
s	PRO197-GLY210

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
G	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
G	ASP132-ILE144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	243
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
r	MET22-LEU42
r	LEU351-PRO371
r	ILE391-THR413
r	ALA435-LEU455
l	TRP407-PHE429
l	LEU457-VAL477
l	MET482-LEU502
l	GLY582-PHE602
r	SER60-SER80
r	MET98-PHE118
r	LEU147-ILE167
r	ILE193-HIS213
r	PRO224-MET244
r	MET257-LEU277
r	SER284-ILE303
r	SER308-ALA330

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