7UXC

cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001002	molecular_function	RNA polymerase III type 1 promoter sequence-specific DNA binding
A	0001003	molecular_function	RNA polymerase III type 2 promoter sequence-specific DNA binding
A	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
A	0001156	molecular_function	TFIIIC-class transcription factor complex binding
A	0001558	biological_process	regulation of cell growth
A	0001932	biological_process	regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0002296	biological_process	T-helper 1 cell lineage commitment
A	0003007	biological_process	heart morphogenesis
A	0003179	biological_process	heart valve morphogenesis
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006112	biological_process	energy reserve metabolic process
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006468	biological_process	protein phosphorylation
A	0006954	biological_process	inflammatory response
A	0006974	biological_process	DNA damage response
A	0007010	biological_process	cytoskeleton organization
A	0007040	biological_process	lysosome organization
A	0007281	biological_process	germ cell development
A	0007584	biological_process	response to nutrient
A	0008361	biological_process	regulation of cell size
A	0009267	biological_process	cellular response to starvation
A	0009408	biological_process	response to heat
A	0009791	biological_process	post-embryonic development
A	0010506	biological_process	regulation of autophagy
A	0010507	biological_process	negative regulation of autophagy
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0010628	biological_process	positive regulation of gene expression
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0010831	biological_process	positive regulation of myotube differentiation
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0016236	biological_process	macroautophagy
A	0016241	biological_process	regulation of macroautophagy
A	0016242	biological_process	negative regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016605	cellular_component	PML body
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019228	biological_process	neuronal action potential
A	0030030	biological_process	cell projection organization
A	0030163	biological_process	protein catabolic process
A	0030307	biological_process	positive regulation of cell growth
A	0030425	cellular_component	dendrite
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0031295	biological_process	T cell costimulation
A	0031410	cellular_component	cytoplasmic vesicle
A	0031529	biological_process	ruffle organization
A	0031641	biological_process	regulation of myelination
A	0031648	biological_process	protein destabilization
A	0031667	biological_process	response to nutrient levels
A	0031669	biological_process	cellular response to nutrient levels
A	0031670	biological_process	cellular response to nutrient
A	0031929	biological_process	TOR signaling
A	0031931	cellular_component	TORC1 complex
A	0031932	cellular_component	TORC2 complex
A	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
A	0032868	biological_process	response to insulin
A	0032869	biological_process	cellular response to insulin stimulus
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0033173	biological_process	calcineurin-NFAT signaling cascade
A	0034198	biological_process	cellular response to amino acid starvation
A	0035264	biological_process	multicellular organism growth
A	0038202	biological_process	TORC1 signaling
A	0042752	biological_process	regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0043022	molecular_function	ribosome binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043200	biological_process	response to amino acid
A	0043276	biological_process	anoikis
A	0044877	molecular_function	protein-containing complex binding
A	0045335	cellular_component	phagocytic vesicle
A	0045670	biological_process	regulation of osteoclast differentiation
A	0045727	biological_process	positive regulation of translation
A	0045792	biological_process	negative regulation of cell size
A	0045821	biological_process	positive regulation of glycolytic process
A	0045945	biological_process	positive regulation of transcription by RNA polymerase III
A	0045948	biological_process	positive regulation of translational initiation
A	0046777	biological_process	protein autophosphorylation
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0048266	biological_process	behavioral response to pain
A	0048511	biological_process	rhythmic process
A	0048709	biological_process	oligodendrocyte differentiation
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0048738	biological_process	cardiac muscle tissue development
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0050882	biological_process	voluntary musculoskeletal movement
A	0051128	biological_process	regulation of cellular component organization
A	0051219	molecular_function	phosphoprotein binding
A	0051247	biological_process	positive regulation of protein metabolic process
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0051549	biological_process	positive regulation of keratinocyte migration
A	0051647	biological_process	nucleus localization
A	0051896	biological_process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0055006	biological_process	cardiac cell development
A	0055013	biological_process	cardiac muscle cell development
A	0060048	biological_process	cardiac muscle contraction
A	0061431	biological_process	cellular response to methionine
A	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071233	biological_process	cellular response to L-leucine
A	0071456	biological_process	cellular response to hypoxia
A	0071470	biological_process	cellular response to osmotic stress
A	0080135	biological_process	regulation of cellular response to stress
A	0090559	biological_process	regulation of membrane permeability
A	0106310	molecular_function	protein serine kinase activity
A	1900034	biological_process	regulation of cellular response to heat
A	1900181	biological_process	negative regulation of protein localization to nucleus
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A	1903691	biological_process	positive regulation of wound healing, spreading of epidermal cells
A	1904059	biological_process	regulation of locomotor rhythm
A	1904690	biological_process	positive regulation of cytoplasmic translational initiation
A	1905672	biological_process	negative regulation of lysosome organization
A	1905857	biological_process	positive regulation of pentose-phosphate shunt
A	1990253	biological_process	cellular response to leucine starvation
A	2000785	biological_process	regulation of autophagosome assembly
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0006974	biological_process	DNA damage response
B	0007010	biological_process	cytoskeleton organization
B	0010507	biological_process	negative regulation of autophagy
B	0016020	cellular_component	membrane
B	0030307	biological_process	positive regulation of cell growth
B	0030838	biological_process	positive regulation of actin filament polymerization
B	0031669	biological_process	cellular response to nutrient levels
B	0031929	biological_process	TOR signaling
B	0031931	cellular_component	TORC1 complex
B	0031932	cellular_component	TORC2 complex
B	0032008	biological_process	positive regulation of TOR signaling
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0038202	biological_process	TORC1 signaling
B	0043066	biological_process	negative regulation of apoptotic process
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0045821	biological_process	positive regulation of glycolytic process
B	0046889	biological_process	positive regulation of lipid biosynthetic process
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0071456	biological_process	cellular response to hypoxia
B	0071470	biological_process	cellular response to osmotic stress
B	1905857	biological_process	positive regulation of pentose-phosphate shunt
C	0001558	biological_process	regulation of cell growth
C	0001938	biological_process	positive regulation of endothelial cell proliferation
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0006974	biological_process	DNA damage response
C	0008361	biological_process	regulation of cell size
C	0009267	biological_process	cellular response to starvation
C	0009410	biological_process	response to xenobiotic stimulus
C	0010494	cellular_component	cytoplasmic stress granule
C	0010506	biological_process	regulation of autophagy
C	0010507	biological_process	negative regulation of autophagy
C	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
C	0016020	cellular_component	membrane
C	0019901	molecular_function	protein kinase binding
C	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
C	0030295	molecular_function	protein kinase activator activity
C	0030307	biological_process	positive regulation of cell growth
C	0030425	cellular_component	dendrite
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031267	molecular_function	small GTPase binding
C	0031669	biological_process	cellular response to nutrient levels
C	0031929	biological_process	TOR signaling
C	0031931	cellular_component	TORC1 complex
C	0032008	biological_process	positive regulation of TOR signaling
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0035176	biological_process	social behavior
C	0038202	biological_process	TORC1 signaling
C	0042325	biological_process	regulation of phosphorylation
C	0043025	cellular_component	neuronal cell body
C	0044877	molecular_function	protein-containing complex binding
C	0045672	biological_process	positive regulation of osteoclast differentiation
C	0045821	biological_process	positive regulation of glycolytic process
C	0045945	biological_process	positive regulation of transcription by RNA polymerase III
C	0046889	biological_process	positive regulation of lipid biosynthetic process
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071233	biological_process	cellular response to L-leucine
C	0071333	biological_process	cellular response to glucose stimulus
C	0071456	biological_process	cellular response to hypoxia
C	0071470	biological_process	cellular response to osmotic stress
C	0071889	molecular_function	14-3-3 protein binding
C	0140767	molecular_function	enzyme-substrate adaptor activity
C	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
C	1901331	biological_process	positive regulation of odontoblast differentiation
C	1905857	biological_process	positive regulation of pentose-phosphate shunt
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0005829	cellular_component	cytosol
D	0006915	biological_process	apoptotic process
D	0008104	biological_process	protein localization
D	0009267	biological_process	cellular response to starvation
D	0010507	biological_process	negative regulation of autophagy
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032008	biological_process	positive regulation of TOR signaling
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
D	0034198	biological_process	cellular response to amino acid starvation
D	0035556	biological_process	intracellular signal transduction
D	0042593	biological_process	glucose homeostasis
D	0042803	molecular_function	protein homodimerization activity
D	0043495	molecular_function	protein-membrane adaptor activity
D	0046982	molecular_function	protein heterodimerization activity
D	0051219	molecular_function	phosphoprotein binding
D	0061462	biological_process	protein localization to lysosome
D	0071230	biological_process	cellular response to amino acid stimulus
D	0072657	biological_process	protein localization to membrane
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990130	cellular_component	GATOR1 complex
D	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
D	1990877	cellular_component	FNIP-folliculin RagC/D GAP
E	0000287	molecular_function	magnesium ion binding
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006915	biological_process	apoptotic process
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0008104	biological_process	protein localization
E	0008380	biological_process	RNA splicing
E	0009267	biological_process	cellular response to starvation
E	0010507	biological_process	negative regulation of autophagy
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0019003	molecular_function	GDP binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032006	biological_process	regulation of TOR signaling
E	0034198	biological_process	cellular response to amino acid starvation
E	0043200	biological_process	response to amino acid
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043495	molecular_function	protein-membrane adaptor activity
E	0046982	molecular_function	protein heterodimerization activity
E	0051020	molecular_function	GTPase binding
E	0060090	molecular_function	molecular adaptor activity
E	0061462	biological_process	protein localization to lysosome
E	0071230	biological_process	cellular response to amino acid stimulus
E	0072657	biological_process	protein localization to membrane
E	0140767	molecular_function	enzyme-substrate adaptor activity
E	1903432	biological_process	regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
E	1990877	cellular_component	FNIP-folliculin RagC/D GAP
F	0001558	biological_process	regulation of cell growth
F	0001919	biological_process	regulation of receptor recycling
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0005768	cellular_component	endosome
F	0005886	cellular_component	plasma membrane
F	0007032	biological_process	endosome organization
F	0007040	biological_process	lysosome organization
F	0008104	biological_process	protein localization
F	0010874	biological_process	regulation of cholesterol efflux
F	0016020	cellular_component	membrane
F	0016197	biological_process	endosomal transport
F	0031669	biological_process	cellular response to nutrient levels
F	0031902	cellular_component	late endosome membrane
F	0032008	biological_process	positive regulation of TOR signaling
F	0032418	biological_process	lysosome localization
F	0035577	cellular_component	azurophil granule membrane
F	0035579	cellular_component	specific granule membrane
F	0038202	biological_process	TORC1 signaling
F	0042632	biological_process	cholesterol homeostasis
F	0043410	biological_process	positive regulation of MAPK cascade
F	0043495	molecular_function	protein-membrane adaptor activity
F	0045121	cellular_component	membrane raft
F	0051020	molecular_function	GTPase binding
F	0060090	molecular_function	molecular adaptor activity
F	0060620	biological_process	regulation of cholesterol import
F	0070062	cellular_component	extracellular exosome
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071986	cellular_component	Ragulator complex
F	0072657	biological_process	protein localization to membrane
F	0101003	cellular_component	ficolin-1-rich granule membrane
F	0150032	biological_process	positive regulation of protein localization to lysosome
F	1904263	biological_process	positive regulation of TORC1 signaling
F	1990877	cellular_component	FNIP-folliculin RagC/D GAP
G	0001558	biological_process	regulation of cell growth
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005768	cellular_component	endosome
G	0005770	cellular_component	late endosome
G	0005886	cellular_component	plasma membrane
G	0008104	biological_process	protein localization
G	0010008	cellular_component	endosome membrane
G	0010761	biological_process	fibroblast migration
G	0016020	cellular_component	membrane
G	0031902	cellular_component	late endosome membrane
G	0032008	biological_process	positive regulation of TOR signaling
G	0035579	cellular_component	specific granule membrane
G	0038202	biological_process	TORC1 signaling
G	0043410	biological_process	positive regulation of MAPK cascade
G	0060090	molecular_function	molecular adaptor activity
G	0070821	cellular_component	tertiary granule membrane
G	0071230	biological_process	cellular response to amino acid stimulus
G	0071986	cellular_component	Ragulator complex
G	0150116	biological_process	regulation of cell-substrate junction organization
G	1902414	biological_process	protein localization to cell junction
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1990877	cellular_component	FNIP-folliculin RagC/D GAP
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005765	cellular_component	lysosomal membrane
H	0005768	cellular_component	endosome
H	0005770	cellular_component	late endosome
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0008104	biological_process	protein localization
H	0010008	cellular_component	endosome membrane
H	0016020	cellular_component	membrane
H	0019209	molecular_function	kinase activator activity
H	0031902	cellular_component	late endosome membrane
H	0032006	biological_process	regulation of TOR signaling
H	0032008	biological_process	positive regulation of TOR signaling
H	0035579	cellular_component	specific granule membrane
H	0038202	biological_process	TORC1 signaling
H	0043410	biological_process	positive regulation of MAPK cascade
H	0060090	molecular_function	molecular adaptor activity
H	0070062	cellular_component	extracellular exosome
H	0070821	cellular_component	tertiary granule membrane
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
H	1902414	biological_process	protein localization to cell junction
H	1904263	biological_process	positive regulation of TORC1 signaling
H	1990877	cellular_component	FNIP-folliculin RagC/D GAP
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005764	cellular_component	lysosome
I	0005765	cellular_component	lysosomal membrane
I	0008361	biological_process	regulation of cell size
I	0031902	cellular_component	late endosome membrane
I	0032008	biological_process	positive regulation of TOR signaling
I	0038202	biological_process	TORC1 signaling
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0060090	molecular_function	molecular adaptor activity
I	0061462	biological_process	protein localization to lysosome
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071986	cellular_component	Ragulator complex
I	1904263	biological_process	positive regulation of TORC1 signaling
I	1990877	cellular_component	FNIP-folliculin RagC/D GAP
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005765	cellular_component	lysosomal membrane
J	0005829	cellular_component	cytosol
J	0008361	biological_process	regulation of cell size
J	0009615	biological_process	response to virus
J	0010628	biological_process	positive regulation of gene expression
J	0019079	biological_process	viral genome replication
J	0031902	cellular_component	late endosome membrane
J	0032008	biological_process	positive regulation of TOR signaling
J	0032757	biological_process	positive regulation of interleukin-8 production
J	0032991	cellular_component	protein-containing complex
J	0038202	biological_process	TORC1 signaling
J	0043066	biological_process	negative regulation of apoptotic process
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0060090	molecular_function	molecular adaptor activity
J	0061462	biological_process	protein localization to lysosome
J	0071230	biological_process	cellular response to amino acid stimulus
J	0071986	cellular_component	Ragulator complex
J	1900182	biological_process	positive regulation of protein localization to nucleus
J	1904263	biological_process	positive regulation of TORC1 signaling
J	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
J	1990877	cellular_component	FNIP-folliculin RagC/D GAP
K	0003924	molecular_function	GTPase activity
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0006915	biological_process	apoptotic process
K	0008104	biological_process	protein localization
K	0009267	biological_process	cellular response to starvation
K	0010507	biological_process	negative regulation of autophagy
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0031669	biological_process	cellular response to nutrient levels
K	0032008	biological_process	positive regulation of TOR signaling
K	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
K	0034198	biological_process	cellular response to amino acid starvation
K	0035556	biological_process	intracellular signal transduction
K	0042593	biological_process	glucose homeostasis
K	0042803	molecular_function	protein homodimerization activity
K	0043495	molecular_function	protein-membrane adaptor activity
K	0046982	molecular_function	protein heterodimerization activity
K	0051219	molecular_function	phosphoprotein binding
K	0061462	biological_process	protein localization to lysosome
K	0071230	biological_process	cellular response to amino acid stimulus
K	0072657	biological_process	protein localization to membrane
K	1904263	biological_process	positive regulation of TORC1 signaling
K	1990130	cellular_component	GATOR1 complex
K	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
K	1990877	cellular_component	FNIP-folliculin RagC/D GAP
L	0000287	molecular_function	magnesium ion binding
L	0003924	molecular_function	GTPase activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005765	cellular_component	lysosomal membrane
L	0005829	cellular_component	cytosol
L	0006351	biological_process	DNA-templated transcription
L	0006915	biological_process	apoptotic process
L	0007264	biological_process	small GTPase-mediated signal transduction
L	0008104	biological_process	protein localization
L	0008380	biological_process	RNA splicing
L	0009267	biological_process	cellular response to starvation
L	0010507	biological_process	negative regulation of autophagy
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0019003	molecular_function	GDP binding
L	0031669	biological_process	cellular response to nutrient levels
L	0032006	biological_process	regulation of TOR signaling
L	0034198	biological_process	cellular response to amino acid starvation
L	0043200	biological_process	response to amino acid
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0043495	molecular_function	protein-membrane adaptor activity
L	0046982	molecular_function	protein heterodimerization activity
L	0051020	molecular_function	GTPase binding
L	0060090	molecular_function	molecular adaptor activity
L	0061462	biological_process	protein localization to lysosome
L	0071230	biological_process	cellular response to amino acid stimulus
L	0072657	biological_process	protein localization to membrane
L	0140767	molecular_function	enzyme-substrate adaptor activity
L	1903432	biological_process	regulation of TORC1 signaling
L	1904263	biological_process	positive regulation of TORC1 signaling
L	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
L	1990877	cellular_component	FNIP-folliculin RagC/D GAP
M	0001558	biological_process	regulation of cell growth
M	0001919	biological_process	regulation of receptor recycling
M	0005085	molecular_function	guanyl-nucleotide exchange factor activity
M	0005515	molecular_function	protein binding
M	0005764	cellular_component	lysosome
M	0005765	cellular_component	lysosomal membrane
M	0005768	cellular_component	endosome
M	0005886	cellular_component	plasma membrane
M	0007032	biological_process	endosome organization
M	0007040	biological_process	lysosome organization
M	0008104	biological_process	protein localization
M	0010874	biological_process	regulation of cholesterol efflux
M	0016020	cellular_component	membrane
M	0016197	biological_process	endosomal transport
M	0031669	biological_process	cellular response to nutrient levels
M	0031902	cellular_component	late endosome membrane
M	0032008	biological_process	positive regulation of TOR signaling
M	0032418	biological_process	lysosome localization
M	0035577	cellular_component	azurophil granule membrane
M	0035579	cellular_component	specific granule membrane
M	0038202	biological_process	TORC1 signaling
M	0042632	biological_process	cholesterol homeostasis
M	0043410	biological_process	positive regulation of MAPK cascade
M	0043495	molecular_function	protein-membrane adaptor activity
M	0045121	cellular_component	membrane raft
M	0051020	molecular_function	GTPase binding
M	0060090	molecular_function	molecular adaptor activity
M	0060620	biological_process	regulation of cholesterol import
M	0070062	cellular_component	extracellular exosome
M	0071230	biological_process	cellular response to amino acid stimulus
M	0071986	cellular_component	Ragulator complex
M	0072657	biological_process	protein localization to membrane
M	0101003	cellular_component	ficolin-1-rich granule membrane
M	0150032	biological_process	positive regulation of protein localization to lysosome
M	1904263	biological_process	positive regulation of TORC1 signaling
M	1990877	cellular_component	FNIP-folliculin RagC/D GAP
N	0001558	biological_process	regulation of cell growth
N	0005085	molecular_function	guanyl-nucleotide exchange factor activity
N	0005515	molecular_function	protein binding
N	0005764	cellular_component	lysosome
N	0005765	cellular_component	lysosomal membrane
N	0005768	cellular_component	endosome
N	0005770	cellular_component	late endosome
N	0005886	cellular_component	plasma membrane
N	0008104	biological_process	protein localization
N	0010008	cellular_component	endosome membrane
N	0010761	biological_process	fibroblast migration
N	0016020	cellular_component	membrane
N	0031902	cellular_component	late endosome membrane
N	0032008	biological_process	positive regulation of TOR signaling
N	0035579	cellular_component	specific granule membrane
N	0038202	biological_process	TORC1 signaling
N	0043410	biological_process	positive regulation of MAPK cascade
N	0060090	molecular_function	molecular adaptor activity
N	0070821	cellular_component	tertiary granule membrane
N	0071230	biological_process	cellular response to amino acid stimulus
N	0071986	cellular_component	Ragulator complex
N	0150116	biological_process	regulation of cell-substrate junction organization
N	1902414	biological_process	protein localization to cell junction
N	1904263	biological_process	positive regulation of TORC1 signaling
N	1990877	cellular_component	FNIP-folliculin RagC/D GAP
O	0005085	molecular_function	guanyl-nucleotide exchange factor activity
O	0005515	molecular_function	protein binding
O	0005765	cellular_component	lysosomal membrane
O	0005768	cellular_component	endosome
O	0005770	cellular_component	late endosome
O	0005886	cellular_component	plasma membrane
O	0005925	cellular_component	focal adhesion
O	0008104	biological_process	protein localization
O	0010008	cellular_component	endosome membrane
O	0016020	cellular_component	membrane
O	0019209	molecular_function	kinase activator activity
O	0031902	cellular_component	late endosome membrane
O	0032006	biological_process	regulation of TOR signaling
O	0032008	biological_process	positive regulation of TOR signaling
O	0035579	cellular_component	specific granule membrane
O	0038202	biological_process	TORC1 signaling
O	0043410	biological_process	positive regulation of MAPK cascade
O	0060090	molecular_function	molecular adaptor activity
O	0070062	cellular_component	extracellular exosome
O	0070821	cellular_component	tertiary granule membrane
O	0071230	biological_process	cellular response to amino acid stimulus
O	0071986	cellular_component	Ragulator complex
O	1902414	biological_process	protein localization to cell junction
O	1904263	biological_process	positive regulation of TORC1 signaling
O	1990877	cellular_component	FNIP-folliculin RagC/D GAP
P	0005085	molecular_function	guanyl-nucleotide exchange factor activity
P	0005515	molecular_function	protein binding
P	0005764	cellular_component	lysosome
P	0005765	cellular_component	lysosomal membrane
P	0008361	biological_process	regulation of cell size
P	0031902	cellular_component	late endosome membrane
P	0032008	biological_process	positive regulation of TOR signaling
P	0038202	biological_process	TORC1 signaling
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0060090	molecular_function	molecular adaptor activity
P	0061462	biological_process	protein localization to lysosome
P	0071230	biological_process	cellular response to amino acid stimulus
P	0071986	cellular_component	Ragulator complex
P	1904263	biological_process	positive regulation of TORC1 signaling
P	1990877	cellular_component	FNIP-folliculin RagC/D GAP
Q	0005085	molecular_function	guanyl-nucleotide exchange factor activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005765	cellular_component	lysosomal membrane
Q	0005829	cellular_component	cytosol
Q	0008361	biological_process	regulation of cell size
Q	0009615	biological_process	response to virus
Q	0010628	biological_process	positive regulation of gene expression
Q	0019079	biological_process	viral genome replication
Q	0031902	cellular_component	late endosome membrane
Q	0032008	biological_process	positive regulation of TOR signaling
Q	0032757	biological_process	positive regulation of interleukin-8 production
Q	0032991	cellular_component	protein-containing complex
Q	0038202	biological_process	TORC1 signaling
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
Q	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Q	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
Q	0060090	molecular_function	molecular adaptor activity
Q	0061462	biological_process	protein localization to lysosome
Q	0071230	biological_process	cellular response to amino acid stimulus
Q	0071986	cellular_component	Ragulator complex
Q	1900182	biological_process	positive regulation of protein localization to nucleus
Q	1904263	biological_process	positive regulation of TORC1 signaling
Q	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
Q	1990877	cellular_component	FNIP-folliculin RagC/D GAP
R	0000785	cellular_component	chromatin
R	0000976	molecular_function	transcription cis-regulatory region binding
R	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
R	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
R	0001892	biological_process	embryonic placenta development
R	0002250	biological_process	adaptive immune response
R	0003677	molecular_function	DNA binding
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005765	cellular_component	lysosomal membrane
R	0005829	cellular_component	cytosol
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006914	biological_process	autophagy
R	0006959	biological_process	humoral immune response
R	0007040	biological_process	lysosome organization
R	0009267	biological_process	cellular response to starvation
R	0010508	biological_process	positive regulation of autophagy
R	0016020	cellular_component	membrane
R	0019899	molecular_function	enzyme binding
R	0032418	biological_process	lysosome localization
R	0034198	biological_process	cellular response to amino acid starvation
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046983	molecular_function	protein dimerization activity
R	0061406	biological_process	obsolete positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
R	0140367	biological_process	antibacterial innate immune response
R	1990837	molecular_function	sequence-specific double-stranded DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV

Chain	Residue	Details
E	LYS163-VAL180

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL

Chain	Residue	Details
B	MET100-LEU114

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ

Chain	Residue	Details
A	LEU2186-GLN2200

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN

Chain	Residue	Details
A	SER2323-ASN2343

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
I	MET1
A	MET2345
A	ILE2356
P	MET1
D	HIS127
K	SER16
K	GLY17
K	HIS127
A	TRP2239
A	VAL2240
A	THR2245

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
I	THR2
P	THR2
F	SER98
F	SER141
M	SER42
M	SER56
M	SER98
M	SER141

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31314152

Chain	Residue	Details
I	SER67
P	SER67
D	THR36
D	ILE164
K	GLY19
K	THR21
K	THR36
K	ILE164

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:35893977

Chain	Residue	Details
F	CYS3
F	CYS4
M	CYS3
M	CYS4

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874

Chain	Residue	Details
F	LYS20
F	LYS31
F	LYS60
M	LYS20
M	LYS31
M	LYS60

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQ22

Chain	Residue	Details
E	SER76
F	LYS103
F	LYS104
M	LYS103
M	LYS104

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:32868926, ECO:0007744|PDB:6WJ2, ECO:0007744|PDB:6WJ3

Chain	Residue	Details
E	THR90
E	THR96
E	ASP181
L	THR90
L	THR96
L	ASP181

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:35338845, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7T3C

Chain	Residue	Details
E	GLU94
L	GLU94

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6U62, ECO:0007744|PDB:6WJ2, ECO:0007744|PDB:6WJ3, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH

Chain	Residue	Details
E	HIS178
K	LYS244
L	HIS178
D	LYS220
D	LYS230
D	LYS244
K	LYS142
K	LYS220
K	LYS230

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6U62, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH

Chain	Residue	Details
E	LYS179
E	ILE220
L	LYS179
L	ILE220

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH

Chain	Residue	Details
E	SER219
L	SER219

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER2
L	SER2

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER15
L	SER15

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99K70

Chain	Residue	Details
E	THR96
L	THR96

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715

Chain	Residue	Details
C	LYS1097

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260

Chain	Residue	Details
C	THR700

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303

Chain	Residue	Details
C	LYS932
C	LYS948

---