7UQJ

Cryo-EM structure of the S. cerevisiae chromatin remodeler Yta7 hexamer bound to ATPgS and histone H3 tail in state II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0003682	molecular_function	chromatin binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005829	cellular_component	cytosol
A	0006261	biological_process	DNA-templated DNA replication
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006337	biological_process	nucleosome disassembly
A	0006338	biological_process	chromatin remodeling
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0034080	biological_process	CENP-A containing chromatin assembly
A	0042393	molecular_function	histone binding
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0140658	molecular_function	ATP-dependent chromatin remodeler activity
A	0140674	molecular_function	ATP-dependent histone chaperone activity
A	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000775	cellular_component	chromosome, centromeric region
B	0000785	cellular_component	chromatin
B	0003682	molecular_function	chromatin binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005829	cellular_component	cytosol
B	0006261	biological_process	DNA-templated DNA replication
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0006337	biological_process	nucleosome disassembly
B	0006338	biological_process	chromatin remodeling
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0034080	biological_process	CENP-A containing chromatin assembly
B	0042393	molecular_function	histone binding
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0140658	molecular_function	ATP-dependent chromatin remodeler activity
B	0140674	molecular_function	ATP-dependent histone chaperone activity
B	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000775	cellular_component	chromosome, centromeric region
C	0000785	cellular_component	chromatin
C	0003682	molecular_function	chromatin binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0006261	biological_process	DNA-templated DNA replication
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006337	biological_process	nucleosome disassembly
C	0006338	biological_process	chromatin remodeling
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0034080	biological_process	CENP-A containing chromatin assembly
C	0042393	molecular_function	histone binding
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0140658	molecular_function	ATP-dependent chromatin remodeler activity
C	0140674	molecular_function	ATP-dependent histone chaperone activity
C	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000775	cellular_component	chromosome, centromeric region
D	0000785	cellular_component	chromatin
D	0003682	molecular_function	chromatin binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0006261	biological_process	DNA-templated DNA replication
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006337	biological_process	nucleosome disassembly
D	0006338	biological_process	chromatin remodeling
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0034080	biological_process	CENP-A containing chromatin assembly
D	0042393	molecular_function	histone binding
D	0045815	biological_process	transcription initiation-coupled chromatin remodeling
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0140658	molecular_function	ATP-dependent chromatin remodeler activity
D	0140674	molecular_function	ATP-dependent histone chaperone activity
D	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000775	cellular_component	chromosome, centromeric region
E	0000785	cellular_component	chromatin
E	0003682	molecular_function	chromatin binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005829	cellular_component	cytosol
E	0006261	biological_process	DNA-templated DNA replication
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0006337	biological_process	nucleosome disassembly
E	0006338	biological_process	chromatin remodeling
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0034080	biological_process	CENP-A containing chromatin assembly
E	0042393	molecular_function	histone binding
E	0045815	biological_process	transcription initiation-coupled chromatin remodeling
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0140658	molecular_function	ATP-dependent chromatin remodeler activity
E	0140674	molecular_function	ATP-dependent histone chaperone activity
E	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000775	cellular_component	chromosome, centromeric region
F	0000785	cellular_component	chromatin
F	0003682	molecular_function	chromatin binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005829	cellular_component	cytosol
F	0006261	biological_process	DNA-templated DNA replication
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0006337	biological_process	nucleosome disassembly
F	0006338	biological_process	chromatin remodeling
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0034080	biological_process	CENP-A containing chromatin assembly
F	0042393	molecular_function	histone binding
F	0045815	biological_process	transcription initiation-coupled chromatin remodeling
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0140658	molecular_function	ATP-dependent chromatin remodeler activity
F	0140674	molecular_function	ATP-dependent histone chaperone activity
F	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
G	LYS15-LEU21

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site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVIgATNrpdaVDpALr.R

Chain	Residue	Details
A	VAL555-ARG573

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11751634, ECO:0000269|PubMed:11752412, ECO:0000269|PubMed:12152067, ECO:0000269|PubMed:12353038, ECO:0000269|PubMed:12845608, ECO:0000269|PubMed:15949446, ECO:0000269|PubMed:16122352, ECO:0000269|PubMed:16168379, ECO:0000269|PubMed:16185711, ECO:0000269|PubMed:17194708

Chain	Residue	Details
G	LYS5
B	GLY454
C	GLY454
D	GLY454
E	GLY454
F	GLY454

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
G	LYS10
G	LYS19
C	ALA2
D	ALA2
E	ALA2
F	ALA2

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10911986, ECO:0000269|PubMed:10975519, ECO:0000269|PubMed:15719021

Chain	Residue	Details
G	SER11
B	SER11
C	SER11
D	SER11
E	SER11
F	SER11

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-butyryllysine; alternate => ECO:0000269|PubMed:19113941, ECO:0000269|PubMed:27105113

Chain	Residue	Details
G	LYS15
B	SER17
C	SER17
D	SER17
E	SER17
F	SER17

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:19113941

Chain	Residue	Details
G	LYS24
B	SER94
C	SER94
D	SER94
E	SER94
F	SER94

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	THR212
B	THR212
C	THR212
D	THR212
E	THR212
F	THR212

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR229
B	THR229
C	THR229
D	THR229
E	THR229
F	THR229

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER241
E	SER285
F	SER241
F	SER285
A	SER285
B	SER241
B	SER285
C	SER241
C	SER285
D	SER241
D	SER285
E	SER241

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER259
B	SER259
C	SER259
D	SER259
E	SER259
F	SER259

---

site_id	SWS_FT_FI10
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER367
C	SER369
C	SER370
C	SER735
D	SER367
D	SER369
D	SER370
D	SER735
E	SER367
E	SER369
E	SER370
A	SER369
E	SER735
F	SER367
F	SER369
F	SER370
F	SER735
A	SER370
A	SER735
B	SER367
B	SER369
B	SER370
B	SER735
C	SER367

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER1142
E	SER1256
F	SER1142
F	SER1256
A	SER1256
B	SER1142
B	SER1256
C	SER1142
C	SER1256
D	SER1142
D	SER1256
E	SER1142

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